* Author Topic: azoospermia newbie (chromosome abnormality)  (Read 1236 times)

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Offline elizabeth84

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Hi
My partner and I are new on here, we'd just like to know if anyone else is going through what we are and also if they have managed to succeed with IVF.
My partner has been diagnosed with azoospermia due to a chromosome abnormality, he's just had an op to see if we can retrieve any sperm surgically so fingers crossed but we don't want to build our hope up.
Has anyone else been diagnosed with this?
Any help or advise or even just personal experience will be greatly appreciated as its all new to us!
Thanks

Offline nvb

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Re: azoospermia newbie (chromosome abnormality)
« Reply #1 on: 31/12/10, 17:30 »
Hiya...when you say Chromosome Abnormality.....do you mean Y chromosome deletion???
My DP is azoospermic but had an Open TESE where sperm was found and frozen. We have had 3 cycles of ICSI. I did get 1 BFP but had a missed miscarriage at 8+4.
Have a look on the NOA thread as some of the ladies on there have been successful xx
 

Offline Tillypops

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Re: azoospermia newbie (chromosome abnormality)
« Reply #2 on: 31/12/10, 19:54 »
Here's a link to the NOA thread Elizabeth:

http://www.fertilityfriends.co.uk/forum/index.php?topic=249979.0

Tilly
xxxx

Offline elizabeth84

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Re: azoospermia newbie (chromosome abnormality)
« Reply #3 on: 1/01/11, 15:43 »
Thanks for the link i'll have a look now!
Yes, he has deletion of the Y chromosome, we don't really no much about it really or what the chances of us finding any sperm from surgical sperm retrival are but we've got our fingers crossed :)
If anyone else has this it would be great to hear your experiences.
Thanks

Offline elizabeth84

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Re: azoospermia newbie (chromosome abnormality)
« Reply #4 on: 25/01/11, 21:10 »
Hi everyone!

Just an update.............we've since had the results back from the biopsy and no sperm was found :(
Think our only option is donor sperm now but trying to stay positive about this.  We have an appointment with our andrologist to discuss our options.

Any similar experiences would be greatly appreciated as we can't really talk to anyone about what we're going through as my other half is embarrased (even though he shouldn't feel like this!)

Has anyone got deletion of the y chromosome? Alot of male infertility seems to be a mystery but after joining this site it helps to know we're not the only ones going through this.

Offline nvb

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Re: azoospermia newbie (chromosome abnormality)
« Reply #5 on: 26/01/11, 09:58 »
Hi there...so sorry to read that it was not good news. Please have a look at the NOA thread as I'm sure there are ladies on there with positive stories.
My DP was stunned when we discovered he was azoospermic but has come to terms with things over the last 3 years and even jokes (only to me though) about being a 'jaffa'. It's such a blow to their manhood. Just keep reassuring him that you love him and don't feel any different about him xxxx

Offline Sheilaweb

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Re: azoospermia newbie (chromosome abnormality)
« Reply #6 on: 26/01/11, 10:15 »
Elizabeth,
My hubby was eventually diagnosed as NOA due to his epilepsy medication after 2 SA's came back with a 0 count, after we had been referred for IUI !!!!! We were then referred to Centre for Life for ICSI treatment and they told us straight away it wasn't going to be worth the bother putting hubby through TESE...and put us on the waiting list for a suitable donor.
We had read on the NOA thread that a number of couples had sworn by Wellman multivitamins - well, it was going to take us six months to get a donor, so we thought we had nothing to lose by hubby taking the multivitamins....and they didn't interfere with his epilepsy medicaion.
I am sooo pleased to say that by the time we got to EC, hubby was on good form - and we produced between us and the clinic, a single two celled embryo (Tictac)
We're delighted to be celebrating our gorgeous daugthers first birthday next week x

Wishing you every success.
Sheila

Offline elizabeth84

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Re: azoospermia newbie (chromosome abnormality)
« Reply #7 on: 26/01/11, 21:32 »
Thanks for your replies!
We've just been looking at the wellmans supplements and we're definetly going to get some, we've got nothing to loose.
We're realists so know it prob won't work but it's worth a shot!
If anyone can recommend anything else that would be great.
Also has anyone else had a second biopsy where sperm has been found or do ppl tend to just have the one?

Offline ceci.bee

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Re: azoospermia newbie (chromosome abnormality)
« Reply #8 on: 28/01/11, 16:20 »
Hi Elizabeth hun
 
I am so sorry to see you posting here, it is a horrible diagnosis to come to terms with (takes a really long time!). My Dh was diagnosed with NOA back in Summer 2008 and we found out he has a Y gene deletion. He has an AZFc deletion which is the only one associated with successful pregnancies. Other types of y gene deletions are not associated with pregnancies, so it is worth asking your doctor which type he has (AZFc is the most common). There are a couple of other women on here including DizzyD whose partners also have thes same deletion but it is really rare, about 1:1-2million. It is what is known as a spontaneous deletion - there is no known cause and it just means that the sperm that made DH from his dad happened to carry that deletion which arose when the sperm was made. I spent a lot of tiem being angry at the sperm that made DH being the cause of our problems ( ^idiot^  I know) until I realised it made all the nice things about him too that I love and would never change.
 
We have been on a long journey since then, and easiest if you read my diary (click on the link in my signature) to get an idea. It is possible to get pregnant with sperm from a y gene deletion (Dizzy is not posting at the moment as her new son George is in SCBU but doing well), but the sperm are often scanty and hard to find at a standard TESE. We had a negative first TESE adn my eggs had to be frozen, and we went to New York for treatment with Dr SChelgel at CRMI as he is the best andrologist (in my opinion) in the world who specialises in y gene deletions and has a 50-70% pregnancy rate using sperm from y gene deleted men. He got sperm for us, and we got pregnant, but sadly miscarried. If you read my diary you will read about our journey to switch to using a donor, although we have not ruled out going back to NYC in the future.
 
Dizzy had a negative cycle first time, and got pregnant second cycle -the lab at CRMI (the clinic in NYC) managed to find sperm in her DH's ejaculate, even though he had a negative TESE at the Lister clinic in London.
 
Basically there is still hope of using DH's sperm, but it is a really tough road.   I am happy to chat on PM and answer any questions you may have, it is a rough place you are in now esp after the negative TESE  ^hugme^ ^hugme^ ^hugme^ ^hugme^ ^hugme^ ^hugme^ ^hugme^  and am sending you loads of hugs
lots of love
C :-*

 

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