* Author Topic: PR Research Thread - NO CHIT CHAT!!!!!  (Read 62831 times)

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Offline SiobhanG

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Re: PR Research Thread - NO CHIT CHAT!!!!!
« Reply #10 on: 10/03/10, 19:25 »
Hi

I know Sam has posted a lot of the more useful DHEA research stuff but I thought some
of you might be interested in this - particularly as it was only just published in Sept 09. It
is regarding DHEA and miscarraige. It was done by The Center for Human Reproduction-New York. (who seem to be leading the way with this)  I haven’t posted the complete paper, (as it is a pdf and a bit long winded to copy each section of it!
 However I can pm the complete paper to anybody who wants it.

Background:
Dehydroepinadrosterone (DHEA) supplementation improves pregnancy chances inwomen with diminished ovarian reserve (DOR), by possibly reducing aneuploidy. Since a largemajority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage rates.

Methods: We retroactively compared, utilizing two independent statistical models,
miscarriagerates in 73 DHEA supplemented pregnancies at two independent North American infertilitycenters, age-stratified, to miscarriages reported in a national U.S. in vitro fertilization (IVF) database.

Results: After DHEA supplementation the miscarriage rate at both centers was 15.1% (15.0% and15.2%, respectively). For DHEA supplementation Mantel-Hänszel common odds ratio (and 95%confidence interval), stratified by age, was significantly lower, relative to odds of miscarriage in thegeneral IVF control population [0.49 (0.25-0.94; p = 0.04)]. Miscarriage rates after DHEA were significantly lower at all ages but most pronounced above age 35 years.

Discussion: Since DOR patients in the literature are reported to experience significantly higher miscarriage rates than average IVF patients, the here observed reduction in miscarriages after DHEA supplementation exceeds, however, all expectations.
Miscarriage rates after DHEA not only were lower than in an average national IVF population but were comparable to rates reported innormally fertile populations. Low miscarriage rates, comparable to those of normal fertile women,are statistically
impossible to achieve in DOR patients without assumption of a DHEA effect on
embryoploidy. Beyond further investigations in infertile populations, these data,
therefore, also suggest the investigations of pre-conception DHEA supplementation in normal fertile populationsabove age 35 years.

I will also like to add here, when I asked my consultant at the Lister about taking DHEA, he said it was fine. I questioned whether he had seen any patients on it produce more eggs, he said 4/7 women he had treated had gotten an extra 2 eggs - he did however say that this could have been a co-incidence. Still I think many of us would be happy with one extra egg!


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    Offline SiobhanG

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #11 on: 11/04/10, 21:34 »
    Kisspeptin:
    New research into the hormone kisspeptin, which triggers puberty, shows it has the potential to help infertile women whose periods have stopped due to a hormone imbalance.

    Have previously posted about this on the PR thread but some new studies going on with this
    http://news.bbc.co.uk/1/hi/health/7945600.stm


    I first heard about it on radio 4 - here's the programme link
    http://www.bbc.co.uk/radio4/womanshour/04/2009_11_tue.shtml

    This post contains an unconfirmed link/information and readers are reminded that fertilityfriends.co.uk or its owners are not responsible for the content of external internet sites


    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #12 on: 12/04/10, 09:39 »
    Luteal Phase Defect

    This is why we take progesterone.  You can find out if you may have a LPD if you have your progesteronen level tested 7 days after ovulation.  Some less knowledgable doctors still tell women to test progesterone on day 21 of their cycle, which is silly at that only applies if you have a perfect 28 day cycle and ovulate on day 14 - most of the women i know with fertility issues absolutley do not.  Your progesterone level should peak 7 days after ovulation (cycle monitoring being the best way to show exactly when you ovulated). Results above 30 are fine.  Mine were often around 27 or 28.

    Luteal Phase Defect

    A luteal phase is the time in a woman’s cycle between ovulation and
    menstruation. In a pregnant woman, during the luteal phase the fertilized
    egg will travel from the fallopian tube and into the uterus for
    implantation. The luteal phase is normally 14 days long and on an average it
    can be anywhere from 10 to 17 days long. If your luteal phase lasts anything
    under 10 days it is considered a luteal phase defect. But some doctors
    believe that if the luteal phase falls under 12 days, then it is a problem.
    If you conceive and you have a luteal phase defect, you will have an early
    miscarriage.

    A luteal phase defect cannot sustain a pregnancy because the uterine lining
    in these women begins to break down, bringing on the menstrual bleeding and
    causing an early miscarriage. There could be more than one reason for the
    luteal phase defect which can be found out after medical analysis. Going by
    statistics, the number one reason for a luteal phase defect is low
    progesterone levels. Your doctor can do a progesterone test on you 7 days
    past ovulation to determine exactly how deficient you are. Once you know
    that there are several ways of correcting this defect.

    Causes of Luteal Phase Defect
    The three main causes of luteal phase defect include poor follicle
    production, premature demise of the corpus luteum, and failure of the
    uterine lining to respond to normal levels of progesterone. These problems
    occur at different times during the cycle but can also be found in
    conjunction with each other.

    Poor follicle production occurs in the first half of the cycle. In this
    case, the woman may not produce a normal level of FSH, or her ovaries do not
    respond strongly to the FSH, leading to inadequate follicle development.
    Because the follicle ultimately becomes the corpus luteum, poor follicle
    formation leads to poor corpus luteum quality. In turn, a poor corpus luteum
    will produce inadequate progesterone, causing the uterine lining to be
    inadequately prepared for the implantation of a fertilized embryo.
    Ultimately progesterone levels may drop early and menses will arrive sooner
    than expected resulting in luteal phase defect.


    Premature failure of the corpus luteum can occur even when the initial
    quality of the follicle/corpus luteum is adequate. In some women the corpus
    luteum sometimes does not persist as long as it should. Here, initial
    progesterone levels at five to seven days past ovulation may be low; even if
    they are adequate, the levels drop precipitously soon thereafter, again
    leading to early onset of menses and hence a luteal phase defect.

    Failure of the uterine lining to respond can occur even in the presence of
    adequate follicle development and a corpus luteum that persists for the
    appropriate length of time. In this condition, the uterine lining does not
    respond to normal levels of progesterone. Therefore, if an embryo arrives
    and tries to implant in the uterus, the uterine lining will not be
    adequately prepared, and the implantation will most likely fail.


    Correction of Luteal Phase Defect
    Fertility charting is an easy way of detecting whether you have luteal phase
    defect. If you do, don’t worry because luteal phase defect can be easily
    corrected. Immediately seek the advice of your physician first before
    starting any treatments to correct it. In most case, luteal phase defect can
    be corrected through over-the-counter remedies and/or with prescription
    drugs.

    1. Over the counter remedies for luteal phase defect:
    The two main over the counter remedies for luteal phase defect are vitamin
    B6 and progesterone cream. Vitamin B6 is perfectly safe and can be taken
    daily in dosages from 50 mg to 200 mg. Taking vitamin B6 every day during
    the entire month will help to lengthen the luteal phase.

    A progesterone cream is usually targeted for menopausal women; however this
    cream is also useful in lengthening the luteal phase. A cream with natural
    progesterone works best. Use about 1/4 to 1/2 a teaspoon of progesterone
    cream spread on the inner arm, inner thigh, neck, and chest - alternating
    places - twice a day from ovulation to menstruation or until the 10th week
    of pregnancy.

    2. Prescription drugs for luteal phase defect:
    The most common prescription drugs for luteal phase defect patients are
    Clomid or progesterone suppositories. Clomid is taken orally as prescribed
    by the doctor. The suppositories are taken through the vagina after
    ovulation has occurred and until either day 14 post ovulation or at some
    point weeks later during a pregnancy, if pregnancy occurred.



    http://www.early-pregnancy-tests.com/lutealphasedefect.html
    Luteal Phase Defect and Fertility
    Defining LPD and what you can do about it...

    Related Article: Learn about Progesterone

    Any medical terminology or phrase with the word "defect" attached to it
    certainly exudes a frightening tone. However, a luteal phase defect might be
    better translated as a simple "shortcoming" in the ability of the body to
    produce sufficient amounts of progesterone during the luteal phase of the
    menstrual cycle. Moreover, this shortcoming is in most cases treatable
    through either medical, dietary, and/or naturopathic means.

    To understand what a luteal phase defect is, we must first define the luteal
    phase and the role of progesterone in regulating the menstrual cycle and
    maintaining a pregnancy. The luteal phase is simply the second half of the
    menstrual cycle - the two-week period spanning from ovulation to
    menstruation. It's called the luteal phase due to the fact that, following
    ovulation, the corpus luteum begins producing the hormone progesterone.
    (While estrogen is dominant during the first half the cycle, progesterone
    governs the second half, or luteal phase.) The corpus luteum only comes into
    being after the egg is released. In fact, a corpus luteum is nothing other
    than the ovarian follicle - but transformed into another role following
    ovulation.

    Progesterone performs a number of reproductive functions: Among, these, it
    warms the body. It builds the uterine lining for implantation of a
    fertilized egg. In the case of pregnancy, it prevents menstruation - thus
    you experience a missed period. When a woman becomes pregnant, progesterone
    levels should remain high and the menstrual cycle will be placed on "hold".


    In this image, the luteal phase corresponds with the increase in body
    temperature associated with ovulation and the production of progesterone by
    the corpus luteum. This image represents and idealized 28-day cycle with
    normal luteal/progesterone functioning. BBT Charting can help you identify a
    luteal phase defect. Also see: What Can BBT Charting Tell Me?

    For most women, the luteal phase will last about fourteen days, though it
    can span anywhere from ten to seventeen days and still be considered
    "normal". A luteal phase defect is typically associated with a shortened
    luteal phase of around ten days or less (though there is some debate as to
    what defines a luteal problem or shortened phase). In most cases, a luteal
    phase defect is attributable to low progesterone levels or
    insufficient/unsustained progesterone production by the corpus luteum.

    With the decrease of progesterone, the uterine lining begins to break down
    (or will not develop properly in the first place) and menstruation takes
    place. For women who exhibit symptoms of luteal phase defect, menstruation
    simply takes place sooner than it should (and the cycle phases will not be
    in balance). Also, the uterine lining may not "build" to a healthy point
    where implantation of a fertilized egg can take place. However, in the event
    a pregnancy is achieved, LPD may also initiate menstrual bleeding and cause
    an early miscarriage.

    The causes of luteal phase defect can be traced to a few principle factors.
    First off, a luteal phase problem may have its root in the first half of the
    cycle. That is to say, for the corpus luteum to function properly, it must
    develop and fully mature in its earlier incarnation as an "ovarian
    follicle". Maturation of the ovarian follicle requires adequate follicular
    development brought about by another reproductive hormone - follicle
    stimulating hormone, or FSH. Low levels of FSH (or stress on the ovarian
    follicle) can prevent its full maturation; thus, during the luteal phase,
    this may lead to a corpus luteum that is unable to perform its proper
    function in producing progesterone at adequate or sustained levels. However,
    failure of the corpus luteum may also occur even in the case of a healthy,
    fully-developed follicle. In either situation, the corpus luteum prematurely
    falters or fails to deliver adequate levels of progesterone.

    Here's where bbt charting comes in. If you are bbt charting, you'll be able
    to identify a short luteal phase (as well as cycle irregularity or ovulation
    problems). If you suspect that you have a luteal phase defect, you can then
    discuss your chart with your doctor and s/he can suggest treatments or
    pursue further testing.

    As luteal phase defect may be the result of hormonal imbalances, your doctor
    or naturopath may suggest any number of remedies, from vitamin and fertility
    supplements (containing the herb, vitex agnus castus) to acupuncture.
    Supplements like FertilAid contain vitex and are designed to help support
    cycle balacne and regularity. Also, natural progesterone creams may also
    prove beneficial in supporting the luteal phase of your cycle. Your doctor
    may also suggest prescription medications as well. In any case, the
    important thing to remember is that luteal phase defect can be corrected in
    most situations. And if you are trying-to-conceive, consider fertility
    charting as not just a means to predict ovulation, but as a general tactic
    for learning about your body's stages and phases.


     




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    Offline Han72

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #13 on: 3/06/10, 17:31 »
    Well not necessarily useful information but still interesting....

    I found this article about ethnicity and IVF.  It jumped out at me cos I'm a "poor responder" despite having normal hormone levels. To mis-quote Ali G is looks like it really is cos I is black ;D ;D ;D

    http://www.fertstert.org/article/S0015-0282(08)00725-5/abstract




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    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #14 on: 21/07/10, 18:05 »
    This was published on a POF website I am on. It's only one woman, so I don't want to be too excited as of course they would need to do this for a lot more women for it to be significant.
     
     http://www.ncbi.nlm.nih.gov/pubmed/20618099?dopt=Abstractplus     Reversal of Premature Ovarian Failure in a Patient with Sjögren Syndrome Using an Elimination Diet Protocol.    Abstract Background: Premature ovarian failure is diagnosed with a picture of amenorrhea, elevated follicle-stimulating hormone (FSH), and age under 40 years. Twenty percent (20%) of patients with premature ovarian failure have a concomitant autoimmune disease. Cases of premature ovarian failure associated with Sjögren syndrome have been reported in the literature. Patient and method: We report a case of a 42-year-old white woman with Sjögren syndrome and premature ovarian failure who underwent a reversal of her premature ovarian failure and restoration of normal menses using an elimination diet protocol. The patient was diagnosed with her rheumatological condition in 2005 and started on disease-modifying antirheumatoid drugs, which were taken intermittently due to a concern over medication side-effects. Her menses became irregular at the time of initial diagnosis and finally ceased in 2006, with a dramatic elevation in her FSH, indicative of autoimmune-induced premature ovarian failure. In March 2009, she commenced an elimination diet protocol, eliminating gluten, beef, eggs, dairy products, nightshade vegetables, refined sugars, and citrus fruit for 4 months. Results: Her repeat laboratory tests after 4 months showed a drop in FSH from 88 to 6.5 and a drop in erythrocyte sedimentation rate from 40 to 16. Her menses also resumed and her rheumatological symptoms significantly improved. Conclusions: It is hypothesized that the restoration of normal menses was caused by reduced inflammation in the ovarian tissue and supports the hypothesis that the gut immune system can influence autoimmune disease and inflammation.
     
     
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    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #15 on: 23/07/10, 19:58 »
    As a reminder:  I wanted to start this thread to save our research only.  Please do not post anything but research on this thread.  For chit chat or any questions, please go to the usual PR Thread!!!
      Please post any questions on the PR thread, and please do not post to mark the thread.  We want to keep this thread for research only so for new members the research does not become lost amoungst the chit chat. 
     
     
     How to take DHEA: The CHR recommend 75mgs micronised pharmactetical grade DHEA per day, 25mgs taken 3 x times a day.  You stop only on your second positive pregnancy test, usually taken a few days after the first test.  Some of us found side effects such as insomnia with DHEA.  We have found taking DHEA with food helps, and taking 50mgs in the morning and 25mgs with lunch helps to reduce the insomnia.  As an aside, the insomnia seems to pass if you persist for a few weeks, your body seems to adjust and the insomnia stops.  I do not recommend dropping the dose down to 50mgs as when I spoke with the CHR they did not recommend this.     
     
    Which brand of DHEA?
     
     I was taking the DHEA from the CHR, which is expensive. Missyg who also has POF and a baby after taking DHEA also was taking DHEA as it stopped her POF symptons, she is a good benchmark as without a good quality DHEA her POF symptoms returned.  Missyg was taking Micron 5 DHEA Ultra Micronized DHEA from www.dhea.com  after her supply from the CHR ran out, and she found this brand worked for her.     
     
    (There seems to be some problems with the dhea.com website. I contacted the US company who make this brand and have this contact to order.)

    " The www.dhea.com site is still working. You can call our virtual London number
    0208 002 9838 and it will ring at our USA office. We can take your order over the telephone."

    /links

       

    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #16 on: 23/07/10, 20:33 »
    When to stop DHEA: I just remembered something in addition to below. The CHR have published showing the women who have DHEA pregnancies have a lower miscarriage rate than the general population (which is interesting, given most, if not all, of these women have some degree of DOR).  Both Missyg and I fell pg, stopped our DHEA and had a mc - I don't think this was related to stopping DHEA at all, but it did make me think that DHEA is a hormone, and it could be true that no major hormonal changes are a good idea in early pg. 

     
     
    The next time I fell pg on DHEA, I came off it very gradually - in fact I was still on 25mg at 12wks pg!  I cut down by breaking the tablets, and came off it very very slowly.  Missyg actually stayed on DHEA right to the end of her pg, I think she was on 25mg in the end.

    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #17 on: 5/08/10, 21:10 »
    The US Clinics.
     
    I receive PMs from time to time from people wondering about the US clinics. I thought it may help to put out there what I have found out when researching.    I thought I was going to the US for treatment, so paid for consultations with 4 of the big clinics – CHR, CCRM, Cornell and SIRM, and thoroughly went through the stats for each clinic (this was in 2009 remember, so I haven’t looked or spoken with them since then).

    To choose my clinic, I downloaded the stats for every clinic in the US, and went through them all looking at success rates and number of patients (to ensure they had treated enough patients to make the stats meaningful)...you can’t imagine how long this took!   The ones worth looking at in my opinion are SIRM, Cornell, the CHR and CCRM.  (If you are like me, super high FSH \ extremely low amh \ POF, Dr Jerome Check or Dr Heard are also worth looking into as both of these have had success treating women with POF – so women with FSH > 40 that haven’t had a period for several months).

     
    To begin with, the success rates for very low amh \ high fsh patients are appalling wherever you go - there is  no miracle protocol. But the US clinics do have a lot more experience than the UK clinics.  In the UK, women with high fsh \ low amh are told by a lot of doctors and RE’s "you won't fall pregnant, go to donor eggs"...when what they SHOULD be told is "statistically you are unlikely to fall pregnant with IVF, but in the UK the Lister will give you a go".  A lot of PRs in the UK fall through the cracks and don't try.  Whereas in the US, a lot, in fact most of the very good clinics, will treat PRs with very high fsh, so there are a lot more women trying in the US than in the UK. 

     
    How to find the success stats for US clinics.
    You can download US success rates from the fabulous SART website which covers pretty much all of the clinics in the US.
    http://www.sart.org/find_frm.html#
    The great thing is you can look at success rates by “diagnosis”.

    You need to select your clinic, but make sure you then filter for Select Diagnosis “Diminished Ovarian Reserve”.  Be sure to look not only at the number of pregnancies, but also the absolute number of DOR patients that they have treated. To be clear, it does not mean anything to have 100% success rate with only one DOR patient.
    Unfortunately, there is not a “standard” definition of DOR, for example one clinic may have a higher amh cut off than another to classify a patient as DOR.

       When considering a US clinic, look at your diagnosis and try to work out the clinic which has the combination of the most experience, combined with the highest success rates for your diagnosis.
    I have all the stats for the US clinics from last year which I could send, but honestly it only takes a few minutes to download for each clinic using SART and you will have the more recent stats. 
    --------------------------
    Where to go with DOR?   
    In 2009 when I was looking at the Lister, they showed me the number of women with amh of 0.1 to 1.0ugL that they have treated over the past FOUR YEARS,(or women with 3 follicles or less).  It was less than 200.  It's very important to note that a clinic like Cornell alone treats more than that “each year”.  SIRM collectively probably does too (but this is spread between their new york, vegas, long island etc clinics). The CHR doesn't treat as many as the others, and CCRM are an ‘excellent clinic’ and clearly have the best success rates on the planet, but the "volume" of very high fsh \ low amh women the CCRM have is a lot less than Cornell or SIRM.  So personally, I wouldn’t have chosen CCRM even though they have the best stats.  (If you are not a DOR patient, do look closely at the CCRM stats – they are exceptional.  Bear in mind that unlike the ARGC in London, they are not selective about their patients – ARGC would not tx me as I have an FSH >10, the CCRM would give me a go with an FSH >40!)

    Given the US clinics have a lot more experience, we in the UK should probably listen to them. Don't get me wrong, I think the Lister is an absolute top clinic and I'm very proud of them that they WILL give PR women like us a try, but we are also a very small part of their ivf population, and I do wish they would listen to the US clinics more as they do have the experience. (OK so in fairness I also understand that as the Lister don't have the experience of the protocols the clinics in the US are using - which of course can change depending on how you are responding through your protocol, so I understand that they don't really want to be "trialling" a new protocol on us, as they don't have the experience of that protocol to tweak it if needed through the cycle, fair enough). If you are reading this Lister - what I would love is for the Lister to send one of their RE’s out to the US clinics for a year or so to learn from them. I mean if you are going to take money from poor responders, shouldn’t you be researching with the clinics that have the most experience and making sure you are offering them the best protocols you possibly can? If ‘Menopur’ doesn’t work first time round, offering ‘Menopur with a twist’ may not be the best protocol.....
    ------------- 
    Though the US clinics were clear with me given my FSH > 40 and AMH 0.1ugl, it is still unlikely to work (well CCRM and Cornell were very clear on this with me that my chances are still very very low and I would be best to go to DE as tx would be a long and expensive road- SIRM and CHR wouldn't be specific - gggggrrrrrr, but did tell me it all depends on whether or not you get to ET.  SIRM told me per "embryo transfer", you have about a 17% success rate, the difficulty is getting to ET, so they are certainly not saying that they WILL get me pregnant.). 

    What these clinics have all found is that for DOR, they do get more "lucky" with the EPP than the microdose protocol.  When I looked in 2009 Cornell were doing a study, in which they believe it will show that the EPP is more likely to be successful for DOR patients than the Microdose.  But keep in mind that the success rates of either are still very very low, just that the EPP may be LESS low.  (Who knows, maybe the Lister will be right, and the Cornell study will show that both protocols are the same and it doesn't make any difference, but the doctors I spoke with in the US all did say in their experience the microdose protocol would not be their first choice with DOR patients). I'm looking forward to the Cornell study concluding- either way, as it would be good to know if one protocol is more successful than the others or not.


    Talking with US ladies who have been treated at these clinics

    I read a lot on the pr threads on the US boards (‘ivf connections’ has a wonderful PR section, there are so many of us PRs being treated in the US ), they also do polls of their members.  One poll I found really interesting was that for women with FSH from 15 to 20 (which is high ladies!), 33% have had pregnancies through IVF!! This is IVF not counting the natural BFPs!    Most of the DOR women in the US have been using the EPP for some time now, the poll is not age specific, but I hope you girls find this uplifting, I certainly did.   

    The depressing part of the poll was when you got to my category, FSH 40+, only 2% had babies  :'( :'(  This is in line with the stats that CCRM gave me.   ‘Fertile Thoughts’ website also has a good PR \ high fsh section with a wonderful wonderful group of ladies if you want to discuss experiences of the US clinics, but doesn't have the polls.
    ----------

    Estrogen Priming
    The EPP is also a little different at each clinic - unfortunately.  For example, SIRM downreg using the pill, Cornell seem to use estrace (Note I’ve only heard this from women who were cycling there, not the doctors themselves) .   Some use estrogen injections during stims, others a patch.  Missyg has the details of the CHR protocol, but it's different again.   I’ve seen the drug schedules for 3 of them, these protocols are very complex, it’s absolutely not just like “giving someone a bit of estrogen before starting stims”.    Ladies who have done the EPP RECENTLY in the various US clinics, maybe it would be great if you typed out your drug schedules and published them here so we can compare?

     
    Our experience on the PR thread.  We were lucky that DimSum did the EPP with the SIRM, as well as doing protocols here in the UK, and was able to give us the feedback – she had the same response on both.  Again, proof there is no miracle protocol.  The SIRM are excellent at sales, but they never told me that it was 'sure' that they would get any more eggs, just that in controlling the LH the eggs they did get would be better quality.  If you read our PR thread, there is no doubt that some girls have done better with the SIRM than they ever did in the UK, sometimes more eggs, sometimes less eggs, but better quality and BFPs after years of BFNs in the UK.


       US clinics & DHEA

    CHR are very pro DHEA for DOR, SIRM against (at least in 2009 they were against) for anyone with high FSH. CCRM are undecided – they told me the argument is around whether male hormones (which can increase when you take DHEA) help or damage egg quality, and CCRM told me they have seen studies which show that testosterone damages egg quality,  and others that it also helps! Cornell told me they “didn’t mind” if I took DHEA, but at this stage they do not have an opinion either way.

     
    Is it worth going to the US for treatment?  Of course there is no absolute answer that is right for everyone.  Well, if money and time were no problem, of course it would be worth trying every possible different clinic the world over, but sadly that is not the case for most of us.

     
    Sorry this is so long ladies – I just wanted to make public what I learnt when researching the US clinics to save others the trouble of redoing it all over again, and the expense of telephone consultations with each.   
     
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    Offline Momito

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #18 on: 6/08/10, 14:35 »
    Sam22....in the course of your incredible research (thank you)...did you come across anything about The New Hope Fertility Center in New York?  I went there earlier this year and they seem to be getting a lot of patients rejected by other US clinics.  At 39 (at the time) I was considered a youngster.
     
    In 2009 they had not yet published stats, which might be why it didn´t end up in your research.  Apparently they have had successful, to full term pregnancies with a woman aged 47 and another at 48, low AMH and high FSH (some FSH runs into the 100s, even 200s).
     
    My experience of them was
    i) medically very competent (they follow mini IVF for low AMHers with regular periods) and I did feel in good hands
    ii) but communication for distance patients was cr*p a lot of the time, and I am not the only one to have found this, which can result in spending more and also distress.
    iii) My conclusion was good clinic but can´t quite cope with the numbers of patients being treated at any one time.  No prob if you can spend forever in New York, not so good if you have to rely on good communication to go back and forth and make sure that you have the correct drugs for your return home.  Kept having to remind the nurses that I didn´t live there!
     
    Momito
    xxxx

    Offline TryMeditate

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    Re: PR Research Thread - NO CHIT CHAT!!!!!
    « Reply #19 on: 6/08/10, 20:37 »
    Nix ARGC : Refused to tx me!  They told me my fsh was too high, I was not a suitable candidate for IVF, and they would not tx me at their clinic.  They told me my levels would never be low enough for them to tx me - which is true, I would never have had a day3 FSH below 10.   The Dr I saw (was not Mr T), he was awful, very cold and direct with me... it was an experience that really shook me. He did offer to do cycle monitoring for me when I suggested that was somethiing I was thinking of , as I was still having the odd cycle back then - I got the impression he was happy to take my money, but not for me to mess up their stats.  He also told me I had about a 2% chance of pg and should go to DE. 
     
    As awful as the experience was, I have to say in fairness I don't disagree with them (I do strongly disagree about the 2%, which I told them - as 10% of women with POF and no cycles fall pg... so where does the 2% come from?) ."IF" their view was it wouldn't be fair to take my money given the chance of IVF working for me, then it's fair enough, they were right it's highly unlikely I would respond to IVF with FSH levels like mine.  As you well know, my opinion is "if" your tubes are fine, dh sperm is fine, but your amh \ fsh is in the POF region like mine, you are more likely to fall pg the old fashioned way.  It wasn't pleasant to be turned away by them, but I can't say that I don't understand their reasoning (agian if it's motivated by NOT wanting to take my money, as opposed to not wanting to mess up their stats)
     
    New Hope: Yep, did come accross them.  I didn't take it as far as consulting with them as I thought their number of DOR patients \ stats were not in the region of the others I was looking at.  Remember this was early 2009.  I did like that they offer the cancellation from other clinics service. That is, a lot of the major clinics have follicle cutoffs before they will proceed to EC, for eg - 2 follicles or less they will not do EC, only convert to IUI.  New Hope have some kind of service where if you are cancelled by your clinic, you can call them and they will try to squeeze you in for EC will them. I thought this was nice. I somehow ended up on a montly newsletter from them, and I agree I'm watching with interest as they did publish having a pg with v.high FSH.  I love any clinic who will give us super high FSHers a try.