* Author Topic: Immune issues - start here guide to this section!  (Read 141654 times)

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Offline agate

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This section of the board relates to some of the less commonly investigated reasons for infertility, for example:

immune issues e.g., elevated Natural Killer Cells and TNFalpha ratios, and the infections that may trigger them
clotting issues e.g., MTHFR, Factor V Leiden, Antiphospholipid antibodies
thyroid problems (which are frequently an immune issue) e.g., Hashimoto's, underactive thyroid

It may also be relevant to ladies who want to explore immune aspects of other fertility diagnoses, e.g.,

endometriosis - which according to immune specialist doctors is frequently associated with immune issues
unexplained - which according to immune specialist doctors may be due to undiagnosed immune, clotting, hormonal or physical issues.

Possibly the best place to start is with the FAQ thread

You may want to start with Deciding to See an Immune Specialist
and possibly read the sections under Why in the W part of the FAQ.

We have chat threads on this section for supporting ladies who are having general immunology fertility treatment, and for specific treatments like LIT and Humira and for specific conditions like Underactive Thyroid.   

Additionally, you may want to look at the threads on other sections of the board for clinics you may be considering for immune treatment/testing e.g., Care Nottingham on this section of the board, Fertility & Gynaecology Academy on this section of the board, ARGC on this section of the board and the Lister on this section of the board.


Some immune tests and treatments are contraversial as they can be expensive and there is limited scientific evidence of a high enough standard to satisfy many mainstream fertility doctors.   You may want to read the HFEA's statement here:

http://www.hfea.gov.uk/fertility-treatment-options-reproductive-immunology.html#7



This post contains an unconfirmed link/information and readers are reminded that FertilityFriends.co.uk or its owners are not responsible for the content of external internet sites

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    Offline wishingandhoping

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    Re: Immune issues - start here guide to this section!
    « Reply #1 on: 19/01/12, 19:55 »
    Hello

    Please can you help me understand my immunes? It is so confusing, I have tried looking at it myself but I just can't grasp it.

    Can I PM you my results?


    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #2 on: 19/01/12, 19:58 »
    ok... but if you are happy to post them as a new thread, then if you have any follow up queries I can keep all your info together... otherwise once, I've dealt with a pm I have to delete it and can't keep a copy of my reply or my box would be full

    best wishes

    A x

    Offline wishingandhoping

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    Re: Immune issues - start here guide to this section!
    « Reply #3 on: 19/01/12, 20:01 »
    I am more than happy, i have nothing to hide! Let me know if I have missed anything out!

    Which numbers do I tell you? Tnf-a 11.5, ifn-g 14.8.
    Histone antibodies - positive, thyr.perox.abs - 7. ANA - negative.
    Dna double stranded.abs- 7
    Cardiolipin ab igg - 3.9, cardiolipin ab igm - 8.8
    Nk assay:
    50:1 - 13.3
    25:1 - 8.7
    12.5:1 - 6.4
    Igg conc 12.5 50:1 - 4.6
    25:1 - 4.5
    50:1 - 7.3
    Icg 6.25 25:1 - 6.2
    Then at the bottom it says: note >10% reduction in killing at each effector/target ratio
    Underneath that it has 85.3

    Thank you for the very quick response! x

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #4 on: 20/01/12, 00:27 »
    Tnf-a 11.5, ifn-g 14.8.  I assume those are ratios against IL10?  If so those are quite low
    Histone antibodies - positive - not sure why that is positive if ANA is negative, but any abnormality on these tests should be checked with your gp,
    thyr.perox.abs - 7 - I presume thats a negative
    ANA - negative. 
    Dna double stranded.abs- 7 I presume thats a negative?
    Cardiolipin ab igg - 3.9, cardiolipin ab igm - 8.8 - I presume those are also negative?
    Nk assay:
    50:1 - 13.3 - the killing power of your NKs is normal
    25:1 - 8.7
    12.5:1 - 6.4
    Igg conc 12.5 50:1 - 4.6  - the killing power of your NKs did reduce when ivig was added to the test tube but its probably irrelevant as it was already normal.
    25:1 - 4.5
    50:1 - 7.3
    Icg 6.25 25:1 - 6.2

    there is normally an analysis of your CD3, CD19, CD56 and CD19+5+?

    Offline wishingandhoping

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    Re: Immune issues - start here guide to this section!
    « Reply #5 on: 20/01/12, 15:33 »
    Tnf-a 11.5, ifn-g 14.8.  I assume those are ratios against IL10?  If so those are quite low - they are against IL10 could this be an issue?
    Histone antibodies - positive - not sure why that is positive if ANA is negative, but any abnormality on these tests should be checked with your gp, would the clinic have mentioned to me if there was an issue?
    thyr.perox.abs - 7 - I presume thats a negative
    ANA - negative. 
    Dna double stranded.abs- 7 I presume thats a negative?
    Cardiolipin ab igg - 3.9, cardiolipin ab igm - 8.8 - I presume those are also negative?
    Nk assay:
    50:1 - 13.3 - the killing power of your NKs is normal
    25:1 - 8.7
    12.5:1 - 6.4
    Igg conc 12.5 50:1 - 4.6  - the killing power of your NKs did reduce when ivig was added to the test tube but its probably irrelevant as it was already normal.
    25:1 - 4.5
    50:1 - 7.3
    Icg 6.25 25:1 - 6.2

    there is normally an analysis of your CD3, CD19, CD56 and CD19+5+?

    This is all the information I have - although I have noticed that there are figures next to all of them in brackets showing the references of the ratio.

    On memory they said that I had low figures and I may need a drip. Does this sound right? I have my second immunes test on Monday. It will be interesting to compare.

    Offline wishingandhoping

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    Re: Immune issues - start here guide to this section!
    « Reply #6 on: 20/01/12, 16:24 »
    Hello again!
    I spoke to ARGC and that said that my CD19 is 16 which is slightly raised so may have ivig depending on my next immunes test which is on Monday. Thanks for your help, really appreciate it x  ^hugme^

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #7 on: 20/01/12, 16:28 »
    yes... that does make sense - you have quite low inflammatory:anti-inflammatory cytokine ratios - you do need some level of inflammation to get implantation - so I guess they need to avoid giving you immunosuppressive meds like steroids, but think that a drip (ivig?) might help balance your immunes bring the ratios into the normal range. 

    there are natural remedies that are supposed to be immuno-balancing too - omega3 fish oils (under supplements) , cordyceps (under mycology) that you might want to consider too.

    I assume your clinic would have mentioned if you need to follow up with your gp to check on the positive antihistone result but its probably best to double check.

    Ah.. then it does look as though they haven't given you the rest of the analysis
    CD3, CD19, CD56 and CD19+5+

    best wishes

    A x

    Offline wishingandhoping

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    Re: Immune issues - start here guide to this section!
    « Reply #8 on: 20/01/12, 17:08 »
    Hello

    I am not sure which fish oil to go for, the Nutrasea comes in different flavours how exciting! My DH wants me to ask the clinic before I purchase anything but I have read the information and it's very interesting.

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #9 on: 20/01/12, 17:11 »
    I used to get nutrasea... I think I had the apple flavoured ones.