* Author Topic: Immune issues - start here guide to this section!  (Read 141851 times)

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Offline Aspi

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Re: Immune issues - start here guide to this section!
« Reply #10 on: 31/05/12, 22:24 »
HI Ladies

I pushed my consultant for the tests after a failed ICSI cycle - They came back and low and behold I have Autoimmune issues (they dont know what) and antibodies - I have been told to take DHEA and that I would be placed on steroids during the next cycle and that they expected to get more eggs than they did as my oestrogen was high.

Do you have any advise I should ask him for to get a clearer picture? I did not know DHEA was not licensed and he made out it was a supplement!! Actually a hormone which could make more testosterone and possibly aggravate fibroids.

Any advise on how to pin this down more would be grateful!

ARGC are they really good? thinking of changing to them .........

and CARE nottingham?

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    Offline suzymc

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    Re: Immune issues - start here guide to this section!
    « Reply #11 on: 9/07/12, 10:01 »
    Hi Agate
    Quick question. Do you know if HFEA has updated it's report since 2010 on reproductive immunology? i remain a sceptic but if there are new results into if treatment of immune issues does infact make a difference then i may reconsider.
    Many thanks
    Suzy

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #12 on: 9/07/12, 10:31 »
    no - i don't think hfea have published anything more on the topic - obviously, in journals such as the journal of reproductive immunology there is new research published all the time.

    Offline suzymc

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    Re: Immune issues - start here guide to this section!
    « Reply #13 on: 9/07/12, 14:18 »
    ok, thanks. i'll have a bit of a 'google'

    Offline DaisyBunny

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    Re: Immune issues - start here guide to this section!
    « Reply #14 on: 17/09/12, 12:18 »
     Hi Agate. I hope you're well. I was wondering if you could help me with my level 1 immunes results. I basically asked my doctor for all the tests on your FAQs (which they agreed to) but when my GP e-mailed e the results there was a note at the top stating that some of the thrombophillia screens hadn't been indicated due to lack of clinical details to support the request (!) Anyway here is what I have got; I have been on thyroid meds - 75g for 3 months as my initial TSH was 3.01. My doctor wants me to continue with the meds and they'll test again in a few months time. What tests are missing and I'll try and get them done privately.  Is there anything apart from the TSH that stands out to you? Thank you for your help.

    Full blood count (424..)   
    Total white blood count (XaIdY)   6.9 10^9/L (3.8 - 11)
    Red blood cell count (426..)   4.35 10^12/L (3.9 - 5)
    Haemoglobin concentration (Xa96v)   12.9 g/dL (11.5 - 16.5)
    Haematocrit (X76tb)   0.39  (0.37 - 0.47)
    Mean cell volume (42A..)   90.0 fL (77 - 95)
    Mean cell haemoglobin level (XE2pb)   29.7 pg (27 - 32)
    Mean cell haemoglobin concentration (429..)   33.0 g/dL (31 - 35.5)
    Platelet count - observation (42P..)   239.0 10^9/L (150 - 400)
    Differential white blood cell count (42I..)   
    Neutrophil count (42J..)   4.4 10^9/L (1.8 - 7.5)
    Lymphocyte count (42M..)   2.0 10^9/L (1.5 - 4)
    Monocyte count - observation (42N..)   0.2 10^9/L (0.2 - 0.8)
    Eosinophil count - observation (42K..)   0.1 10^9/L (0.04 - 0.5)
    Basophil count (42L..)   0.1 10^9/L (0 - 0.2)
     
    Code   Result
    Serum total bilirubin level (XaERu)   7 umol/L (5 - 20)
    Serum alanine aminotransferase level (XaLJx)   18.0 iu/L (10 - 40)
    Serum alkaline phosphatase level (XE2px)   39.0 iu/L (25 - 115)
    Serum gamma-glutamyl transferase level (XaES3)   12.0 iu/L (0 - 30) -   Total Protein and Globulins are no longer part of
      the LFT profile.
      If needed please contact the laboratory to discuss
    Serum albumin level (XE2eA)   40.0 g/L (35 - 48)
    Blood glucose level (X772z)   
    Fasting blood glucose level (XE2mq)   5.2 mmol/L (3 - 6) -   A FASTING venous plasma glucose of 7 mmol/L or
      greater is diagnostic of Diabetes Mellitus (WHO).
      FASTING venous plasma glucose values of 6.1 mmol/L
      or greater, but less than 7 mmol/L
      represents impaired fasting glucose (WHO).
    Immunoglobulin level (XE2wI)   
    Serum immunoglobulin A1 level (XaIZd)   1.8 g/L (0.7 - 4.4)
     
     
    Code   Normality   Result
    Serum TSH level (XaELV)   Below range   0.33 miu/L (0.35 - 5.5)
    Serum free triiodothyronine level (XaERq)       5.4 pmol/L (3.5 - 6.5)
    Serum free T4 level (XaERr)       15.2 pmol/L (11.5 - 22.7)
    Thyroid peroxidase antibody level (XaDvU)       34.0 iu/mL (0 - 60)

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #15 on: 17/09/12, 12:26 »
    I think you'd probably want vit D25OH, antinuclear antibodies and thrombophilia screen including antiphospholipid antibodies.

    you are right, only the TSH stands out and your doc's advice seems sensible so long as you don't feel hyperthyroid because you FT4 isn't all that high although your TSH is heading for too low.

    Offline Aspi

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    Re: Immune issues - start here guide to this section!
    « Reply #16 on: 17/09/12, 22:21 »
    I got told that there was no worldwide medical research that had been done - maybe just one paper written but no formalised research as of yet, I volunteered to be a guinea pig! ;-). It seems to make sense and how come those clinics that do take it into consideration have seemingly stronger results?
    I just wonder why there has been no proper research? x

    Offline agate

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    Re: Immune issues - start here guide to this section!
    « Reply #17 on: 17/09/12, 23:32 »
    there are a lot of studies, but all very small.

    basic answer is because full scale research studies cost money and tend only to be done where there is a patentable drug.  the drugs used in immune fertility are out of patent - so there isn't any money to be made by the drugs companies, so no funding.

    its also seen as high risk work because its done on nearly pg/pg women.

    and, its a particularly hard area to do studies in because we all have slightly different problems - so that makes coming up with appropriate test groups and control groups quite hard.

    Offline Aspi

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    Re: Immune issues - start here guide to this section!
    « Reply #18 on: 18/09/12, 09:56 »
    Very interesting thanks Agate! x

    Offline Aspi

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    Re: Immune issues - start here guide to this section!
    « Reply #19 on: 18/09/12, 09:57 »
    p.s. your "mine of useless information", is bloody invaluable! thankyou xxx