Immune issues - start here guide to this section!

[Silver star]

Thanks cordelia & agate x

[FertilityFriends]

[pookiepoo]

Hi,
I'm a bit torn about fishoil and clexane in pregnancy. Especially since a small area of bleed was seen inside my uterus at my first scan. No actual vaginal bleeds.

I'm taking NHP omega 3 support. My clexane dose is 40mg. Is the omega 3 likely to increase any bleeds? Or not and I can take it for its health benefits and aid to reduce inflammation?

Some advice is welcome

Pany

[agate]

I'd happily take 1.5g.  I'd take 5g as long as no sch/bleeding.

[pookiepoo]

Thanks agate. that helps.

[SELL01]

Hi,
Hope you do not mind me jumping onboard here?

I have had one round of NHS funded IVF fresh cycle which worked and I got our BFP with one early blast which resulted in ID twins we were beyond shocked and yet delighted our twins sadly only stayed with us till 11wk4d they were fine 5 days before we still are not fully sure what went wrong report on the babies just showed no abnormalities or defects in either baby boy
Trying to somehow move on now I need to know what else I can do to try and help if we are ever lucky enough to get our BFP again and for it to stick…. 4MMC and I need some sort of answers – St marys are running tests which are due back early feb and looking like cycle 2 will be April/May time.

Should I invest in NK cells test and if so where is best in London or Essex – I do not mind paying but seems a mind field with lots of clinics charging for lots of different things

I am very happy to cycle again at Barts and feel lucky to have the funding but equally want to be wise with our money as to what test are best to have etc….

Please can you help?

Thanks

[agate]

Because of your endo, raised nka and Tnfa is very likely so you might want to ask if they might treat you empirically with steroids, clexane and intralipids.  Otherwise you'd want a test for nk cytotoxicity and cytokines - see faq

[SELL01]

Thanks for your reply, can you suggest where is best to go for these tests in London or Essex?

[agate]

See FAQ under appointments.

[Baby Mama]

Hello,

I wonder if you can please help me. I am new hear and not entirely sure what i an doing !!!!!!!

However i have recently recieved my immune tests results and would like some assistance interpreting it prior to my appointment , just to get my head around the whole thing first. My results are as follows:

NK Assay Inhibition Panel
 
50:1   - 11.2
25:1   - 7.1
12.5:1 - 4.0

IVIG 12.5 mg/ml, 50.1 - 4.4
IVIG 12.5 mg/ml, 25.1 – 5.9
Intralipid 1.5mg/ml 50:1 – 8.1
Intralipid 1.5mg/ml 25:1 – 3.9

% CD3 – 80.1
% CD19 – 16.6
%CD56 – 2.1
% of CD19 cells CD5+  - 7.4

TH1:TH2 intracellular cytokine ratios
 
TNF-a:IL-10 (CD3+CD4+)      33.5
IFN-g:IL-10 (CD3+CD4+)           914.3

Leukocyte Antibody Detection
 
Flowcytometry           
[T-cells] IgM+               94.4
[T-cells] IgG+               51.6
[B-cells] IgM+              1.0
[B-cells] IgG+              6.5
 
DQ Alpha Genotype
 
Me:   DQ Alpha  0102, 0102
DH:   DQ Alpha  0102, 0104


Many thanks and i know you are are not doctors but would really really appreciate any guidance

Gratefully
BM

[agate]

You do have matching DQa, but pretty good nka and lad, so I wouldn't be very worried about about the match.

TNFa is just a little bit high suggesting a little inflammation so anti inflammatory diet -fish oil etc a good idea and maybe your doc will suggest steroids and blood thinners