Immune issues - start here guide to this section!

[agate]

Steroids etc -yes for endo.
Femara is like clomid but better for lining and endo.

Hcg is often 1500u day of et, then every other day til you've done 3.  It's a major hassle for pg tests.  If initial test is +, then you need 2 blood tests 48h apart so you can be really sure.

CVS sounds maybe a good idea. Didnt know you could do that.  I guess you'd have to know what your plan was if it was positive or not the right match?

[FertilityFriends]

[mms]

I will never terminate a heathy embryo even if its not an hla match, I did CVS when pregnant with my child and it was just so hard for me to terminate the pregnancy... but now i think  can only terminate a sickle cell diseased embryo aftern knowing and going througg sickle cell and seeing my child suffer with it.. though he is considered to be lucky and blessed with the mild form.
oh well will discuss with my doctor somtime this week and see if she can consider any of these medications for a natural cycle. thanks a lot for your time and help

[mms]

Hello Agate,
I was just wondering, what if the sperm DNA fragmentation was abnormal! How can that problem be solved or what can be done?

Alsi im just curious to know what are the signs and symptoms of rwproductive immunity and dq alpha hla matching?

[agate]

Alloimmune probs - typically multiple miscarriage/chemical pregnancies, severe reactions -rash, fever etc

Sperm probs - try antibiotics, possibly picsi, otherwise donor sperm

[poppy05]

Hi Agate


I was hoping you could help me make some sense of my test results?
If i'm posting in the wrong place then please move me.


So basically i had the NK cells test done at the lister 2 weeks ago, and i got a call to say i had high killer cells and would need ivig with steroids before commencing fet, which is my final tx, no more after this!


So im going to copy my results as they read, as i dont have a clue what any of it means.




NATURAL KILLER CELLS COUNT


Lymphocyte count - (10/l) 2.803
Total NK cell absolute count (10/L) 300.7
NK (dim) absolute count (10/L) 275.5
NK (bright) absolute count (10/L) 25.15


(Lymphocytes) total NK (%) 10.7
Total NK (dim) (%) 91.6
Total NK (bright) (%) 8.4




ACTIVATION MARKER OF NATURAL KILLER CELL


Total NK CD 69 absolute count (10/L) 1.70
NK (dim) CD69 absolute count (10/L) 1.28
NK (bright) CD69 absolute count (10/L) 0.43


Total NK CD69 (%) 0.57
(total NK) NK (dim) CD69 (%) 0.42
(total NK) NK (bright) CD69 (%) 0.14




NK CELL CYTOTOXICITY ASSAY


NK cell 50:1 - 36%
NK cell 25:1 - 28%
NK cell 12.5:1 - 13%


NK cell 50:1 with IVIG 12.5mg/ml 19% Reduction in killing 47%


NK cell 50:1 with IVIG 6.25mg/ml 27% Reduction in killing 25%


50:1 with prednisolone 10mg/ml 23% Reduction in killing 36%


50:1 with predisolone 5mg/ml 29% Reduction in killing 19%


50:1 with intralipid 3mg/ml 20% Reduction in killing 19%


50:1 with intralipid 1.5mg/ml Reduction in killing 3%


Any help would be much appreciated
Thankyou
Poppy xx

[agate]

killing power looks quite high.... according to the lab test (which I don't really believe works well) you respond ok to steroids which are much cheaper than ivig and quite a lot cheaper than intralipid

[poppy05]

Thanks hun, im considering asking for steroids and intralipids, do you think my nk's would lower enough to hold a pregnancy? i just dont know what to do, ivig is just so expensive, and we really cant afford it, we would have to save for about 10 months at the very least, and i really dont have much time to wait, our frosties need to be used by oct, as not paying for another years storage, im 40 next year and for me thats my cut off point, i dont want to do something that i will regret, but i also dont want to spend 3k on something that i may be able to get away with it having 

[agate]

Its impossible to know without trying it and seeing whether it works for you

[Tigger99]

Hi Agate (and other knowledgeable FFers!)

Just got the results for my LAD test and they are as follows:

[T cells] IgM+       7.0%
[T cells] IgG+        3.5%
[B cells] IgM+       37.7%
[B cells] IgG+        7.3%
Negative

I have just reread Agate's immune FAQ so I guess this means I need LIT?? Or is there something else I can use?

[agate]

you will probably be recommended to try LIT and/or IVIG