* Author Topic: Advice needed after failed first ICSI  (Read 574 times)

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Offline AmberJ

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Advice needed after failed first ICSI
« on: 25/09/16, 21:10 »
Hi Everyone,

This is my first post and I would be extremely grateful for any advice on this matter.

I'm 41yrs old. Never got pregnant naturally after 4yrs of trying with my ex. Last month I had my first IVF treatment with a new partner. Initially I was really encouraged by my doc who told me that he couldn't understand why I had never got pregnant naturally as blood results showed i had the fertility of a 20-something. He did advise ICSI as partner had low sperm count (we found out it was due to protein shakes which he did stop before treatment).

On the day, they retrieved 9 eggs, 8 viable. My partner's sperm was back at normal levels, but they still chose to do ICSI "as a precaution".

The next day, the embryologist phoned to say NOTHING had happened and that was that. Cycle over. No more chances. After speaking to the consultant, he informed me that it could be a fluke or due to my age, egg factor, but he didn't know, wasn't going to investigate and I'd better just go and find a donor who would kindly give me her eggs if I wanted another chance. Of course, a few weeks on I'm still devastated, don't know what to think, but can't help feeling that if I have the fertility of a "20 something" then they should investigate so I can weigh up my options, rather than just send me down the egg donor route. The consultant did say that "there MIGHT be an extra protein on the zona pellucida which could stop the egg hatching", but like I said, wasn't prepared to investigate.

My problem is my partner won't consider a donor egg/adoption etc. etc. He wants our baby. I do too, but this is making the situation even more distressing for me as there's potentially no plan B.

What I want to know is has anyone else been in this situation and have you had any investigations?

Thanks for taking the time to read this x

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    Offline tina11

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    Advice needed after failed first ICSI
    « Reply #1 on: 25/09/16, 21:36 »
    Hi sweetie

    So sorry to hear your story!! Which clinic were you at? It's rare that with icsi none of them made it to even day 2!! Do you think it could be some sort off lab error?

    We has 2 failed fresh cycles with perfect blasts transferred and still bfn. I know exactly how you feel. We got a big on our fet.

    Maybe give it another go at a clinic that specialises with over 40s. I want to say serum in Greece. Don't give up after 2 try. I know it's expensive but its worth another go.


    Xx


    Offline Besidetheseaside

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    Advice needed after failed first ICSI
    « Reply #2 on: 25/09/16, 22:10 »
    Hi AmberJ

    Like tina11 said, don't give up! It makes me so angry that some clinics give you straight away the donor egg speech without even trying hard enough.
    Every cycle is different and you had so many eggs that is a very good sign. I had twice 3 (1 fertilised) and once 7 (4 fertilised) eggs.
    I don't think this clinic is the best choice to be frank. There are a lot of clinics like Lister which is specialised for 'older' girls or ARGH which is quite expensive but one of the best clinics in the UK (your FSH has to be under 10 there). Serum which was mentioned before is also very good but much cheaper and you can combine it with a nice holiday ☺
    I can hardly recommend Mr Ramsey for semen issues, he's expensive but a guru.
    Don't give up!!!!
    x

    Offline AmberJ

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    Advice needed after failed first ICSI
    « Reply #3 on: 25/09/16, 22:41 »
    Thanks ladies. The treatment was at St Mary's, Manchester

    Offline Talkingfrog

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    Advice needed after failed first ICSI
    « Reply #4 on: 25/09/16, 22:44 »
    Hello Amber ,

    Sorry to hear what happened  and that yourclinic doesn't appear to be very helpful.  I think  most people in  that situation would be devastated.

    I assume  from your age it was a private cycle, but  I would expect  a private clinic to want to investigate  more.

    If it was a funded cycle  maybe the consultant didn't  want to  investigate  if there was no funding for you to have a second  go.  (Not excusing or defending but just trying to think of a reason).

    I  would be tempted to look for a different  clinic.  HFEA website has a search facility  or the regional boards on here have a thread  for most clinics.  Most hold open evenings so you can have a look about and ask a few questions  to get a feel for the place.  We went to one clinic to view and we're happy enough with them, but then went to a second and decided they felt more customer  focused and so chose them.

    Might be worth requesting a copy of your notes from the clinic before you leave.  There will be a charge,  but the info may be of use to a new clinic.   I kept my treatment  plan  from my first cycle (funded) so when we went for private  treatment  they could  see how I had responded  ( the notes gave the dose, no and size of follies etc).  Although there was 4 years in between  it gave them an indication  as to how  I responded.

    Not quite sure why he mentioned  about the egg hatching  being an issue.   If they used icsi  the sperm wouldn't  have needed to penetrative the shell  as it would have been injected.   I thought  hatching related to whether the embryo once fertilised to hatch out of the shell.   In older women the outer if the egg can be tougher which could make it harder for the sperm to get in naturally, or the embryo to hatch out.  Our first cycle  with our  current clinic I was a few months  off 41.  At the second  I was a few months  off 42 so the clinic  offered assisted  hatching.   The make  a small whole  in the shell of the embryo  before  transfer  to help it hatch out.  Our clinic offers it free if they think it is appropriate.

    Most clinics offer a free counselling  session  as part of a cycle ( I think it is an obligation ).  Might  be  worth  looking  into  if you thought it would help - even if just to get things off your chest.

    Sending  a hug.  Take care of yourself.
     ^hugme^

    Offline AmberJ

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    Advice needed after failed first ICSI
    « Reply #5 on: 26/09/16, 16:40 »
    Hi Everyone,

    Thanks so much for your replies. It was a funded cycle at St Mary's in Manchester. Am feeling upbeat today, so I'm now in the process of writing a letter to the consultant to ask why he won't investigate.  It may get me nowhere, but I'm sick of the NHS writing me off without a proper explanation. If they had listened to me a decade ago, I'm sure that I wouldn't be in this position - all I was told then was to go away and have more sex!! (I couldn't have been doing it anymore). Grrrrr.

    Talkingfrog:
    Re. the egg shell thing, my partner and I were also scratching our heads about that one. When the consultant saw me to commiserate he hadn't even looked at my notes until we all walked in the room together so I had to tell him everything that had gone on. He just came up with a possible cause out of the blue. Very frustrating esp. when my eggs MIGHT be fine and we're on the brink of deciding do we try again or not since my partner will not consider a donor egg.

    Anyhoo, I better get back to this letter.

    P.S. Does anyone know what sort of investigations re. egg health are carried out and the likely costs? Thanks xx