* Author Topic: Low AMH / High FSH Cycle Buddies - Part 6  (Read 125312 times)

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Offline katkat2014

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Low AMH / High FSH Cycle Buddies - Part 6
« Reply #270 on: 28/02/18, 00:10 »
Hey shady, I only use the selenium that's in the vitafem as it already include 150. When I used zita west pregnancy plan I also added in 50 selenium. I sometimes use the one I bought for DF from Holland barrett as it only include 100 selenium and 15mg zinc so I take one every 2 days if not on vitafem.  Thanks for your reply about the antisperm antibodies. Hope your AF makes an appearance when you need it. Mine has disappeared and wonder if I have a cyst grrrrr

Klik, babyhopeful, blue,Mac thanks for replies on dhea and antisperm antibodies!

Hope everyone is well

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    Offline Helenbeau

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #271 on: 28/02/18, 09:11 »
    Hi ladies,
    Just a quick opinion poll. Iím going for my medicated FET mid March in Brno. They say I can have it 13th, 14th or 15th whatever suits me. 0n a 28 day cycle 13th would be day 5, 14th day 6 and 15th day 7.... I have a day 5 embryo. However itís meducated so there will be no natural ovulation so does it matter which day? Itís just that there are only direct flights on Thursday. Do you think itís totally fine to fly the same day or itís best to fly the day after? Iím sure Iím doing the over analysing thing!

    I always went mad and booked a holiday so Iím flying to India tomorrow, back in time for my FET! Yes ladies I spent some money unrelated to ivf!!! Funnily though Iíll need a scan while Iím out there and the ivf clinic in Goa only charge £13! I bought some viagra too but itís been held at customs so I wonít get it in time and just potentially wasted £140!
    Will catch up proper later xxx

    Offline MA66

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #272 on: 28/02/18, 16:20 »
    Hello ladies

    katkat2014 - I was really surprised that ARGC didn't do anything more than they did.  For all the money I thought they were going to be very different but they really were underwhelming at times I thought.  They also were unconcerned with my TSH at 5 and they said no to me starting levy before I stimulated saying it would reduce very quickly, which of course it doesn't, so it didn't.  They agreed I could start levy at stims, which I find very strange so my levels were likely not low enough when I transferred :(  They added Sildenafil (viagra) 25mg am and pm and clomid 100mg a day from day 3 but I haven't noted when I stopped them, sorry.  Thanks for the selenium info.

    Babyhopeful - great news on your not as low as you expected AMH, what a relief for you.

    klik - thanks for the selenium info re brazil nuts, I'd long forgotten why I ate brazil nuts!  Do you just have two a day?  All the time?

    Mac78 - I've read the book that Sunshine mentioned and I'd also recommend it.  Thanks for sharing your friends experience.  My tsh was back today and its 2.59 so I've emailed create and hopefully they will prescribe levo (as I don't know how much to take) with me pushing even though they said they think less than 3.5 is fine!

    Susie76 - thanks for the tsh answer.  Weirdly I found ARGC really unhelpful with tsh and I regret that I followed their advice and didn't take levo earlier than they agreed for me to. Congrats on the 20 week scan, that's wonderful news which is always nice to hear.

    Blue dolphin - sorry to hear about your bereavement.  I'm glad you have found some comfort in the forum.  I know it keeps me sane!

    Helenbeau - I can't help you with your timing question sorry but have a great holiday.  I hope your viagra getting stuck in customs is the universe intervening, hopefully it will be for the best??

    Can I ask about DHEA please?  I used to take it but found the side effects horrendous.  I could just about cope with the greasy hair and awful spots but the nightmares were horrendous and I was like the walking dead.  But then I read that it could exacerbate endo which I have, so I stopped but now I have read, in the daily mail granted, that it has been shown to help increase the implantation rate, I'm now wondering how much of a no no DHEA is for endo?

    Hi to all I've missed

    Offline queenie123

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #273 on: 28/02/18, 20:26 »
    Guys - did anyone apply for this?

    https://ivf.org.uk/about/blog/lister-fertility-clinic-free-ivf-cycles/

    I asked them at the fertility show if they were doing it any they said no...

    Offline AdelineX

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    « Reply #275 on: 28/02/18, 22:40 »
    Hi, ladies.
    MA66 - if you plan on taking DHEA, test your free testosterone levels before and after 1 month. I did the same and my levels doubled. My endocrinologist warned me it could block my ovaries. Not everyone responds the same way, but I'd insist on testing.

    Helen - good luck with your transfer. Is this the tested embryo ? Keeping everything crossed for you. Medicated cycles work differently, basically you should focus on you lining and progesterone levels. Glad to hear you still enjoy your taveling, IVF can suck out the life of anyone.
    Susie - so glad to hear everything is fine! we are in dire need of good news on this thread! :)
    Shady - waiting is so hard, but it is better to wait than to waste opportunities...

    AFM - no cyst this month, but only 2 antrals visible on day 18. I know things are bad, but they seem to get worse and worse. Not sure if I should just start stimulation on day 2, no matter what, or have a scan then and see if any other antrals showed up and postpone if I still have 2. I wish I could just accept that my ovaries are done instead of waiting for a 'better" month, when I have 3 antrals instead of 2. I feel ridiculous, to be honest.

    Offline klik

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #276 on: 1/03/18, 08:40 »
    Hello, dear ladies!

    Mac: how are you?!

    Shady: still holding out for a natural pregnancy for you! If not, I'd love to be cycle buddies next cycle--I'm hoping your lining will thicken beautifully in that "post-m/c is the most fertile time" sort of way.

    susie: As for ejaculation timing, I must say my DP's anecdotal evidence points to "the least time between the last ejaculation and the sample, the better." I got that impression from other women on here, too... So perhaps (since we are all DOR here and even stims wouldn't get us quintuplets) the ideal thing would be BD'ing in the morning when a sample is due to be provided (which often is the morning of egg retrieval--so if they leave any eggs behind or if you ovulate too early you also have a chance). Most importantly, though, hurray for a successful and reassuring 20-week scan! Amazing!!! Wonderful news... How has pregnancy been treating you?

    Blue: I'm so sorry about your bereavement... I'm glad you're slowly easing yourself back in--giving ourselves time and space to mourn is very important... It's been lovely having you along on this forum and I look forward to cheering you on if/when you decide to cycle!

    katkat: I really want to hope you're pregnant but I'd wager you've tested already... Otherwise, yeah, cysts sometimes delay periods... Hang in there...

    Helen: as Anna said, as long as your lining is ok, the exact timing of transfer is immaterial when your ovulation has been suppressed. That's one of the advantages of a medicated transfer: assuming your lining thickens well, the timing can be adapted to suit your needs. As for flying back, from one perspective I'd say the earlier the better--I'd rather fly before my embryo has even started to think of implanting. However, a transfer is a hugely emotionally intense event, so possibly you want to take it easy that day just so you don't pile even more stuff on top of that intensity. I'd say those are the trade-offs...

    MA66: I have Brazil nuts quite consciously between when AF arrives and ovulation, to help thicken up my lining. I like them, so I have a lot more than two--I don't really think about how many. There is such a thing as too much selenium, but I'm not too worried that I'll be crossing that line. As for DHEA, I think the idea is that it converts to oestrogen, which yeah, is a problem for endo. I think you'd have to think about how bad your endo is and weigh that against how low your natural testosterone levels are (I've never taken DHEA, so please take others' advice on exactly what to test!)

    queenie: Can't believe Lister told you they weren't doing this and then they did it anyway... So frustrating--I'm sorry...

    tily: yes, from the moment I sought to understand why CRGH kept cancelling me for natural cycle IVFs even when I didn't have a cyst (FSH is too high), I've been entirely convinced that AMH and FSH are about quantity, not quality. Good to have even more evidence of that!

    Anna: Don't feel ridiculous. It's natural to want to maximise your chances. You have to decide for yourself, but my personal approach has always been, for egg collections, the earlier the better, no matter my AFC. Well, in fact, it has been to keep collecting, through the ups and downs of my AFC. Because as we know, quality deteriorates with age... and as DOR women, chances are (unfortunately) that we'll need more than one collection... So for me, it's always been "just do it." But it is a hard choice... Especially because multiple collections mean lots of money, time, emotional investment, physical impingements--not to mention its effect on the couple... I hope another antral pops up in any case and makes your choice easy--but if not, good luck with whatever you choose!

    AFM: Bleeding stopped a couple of days ago... I'm on norethisterone so I know roughly when AF should come. And then it starts again. It's been kind of nice to take a break, actually! On the other hand, I'm feeling quite impatient to have another transfer...

    Offline Lulu2017

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    « Reply #277 on: 1/03/18, 15:40 »
    Hello ladies, wow what an amazingly supportive and knowledgable thread this

    I've been reading your stories in awe - you're amazing.

    I am hoping to pick your brains please... I have just had to cancel my third cycle due to poor response (only two follicles growing and the others extremely far behind)

    My two previous cycles have been as follows

    First cycle: long protocol, 300 menopur - 5 mature eggs (three of those matured in the lab) only one egg fertilised, 2 day transfer - BFN

    second Cycle: short protocol, 450 menopur - four mature eggs, again only one fertilised, 2 day transfer - BFN

    I'm 34, with AMH of about 10 pmol but AFC of 4 and we also have severe MFI due to my husband having undescended testicles as a child

    Third cycle was short protocol with 300 menopur but two follicles so we cancelled

    I'm now about to start again but having a tough time deciding what protocol and treatment plan I should go with

    My clinic are saying it's kind of up to me what protocol we do as they don't think it'll make much difference and they hope that last month was just a blip

    I wanted to please ask in your extensive wisdom what kind of protocol is worth exploring - antagonist, flare? (I'm not  sure I'm 100% on the difference tbh but will do research!)

    I need to make a decision Fairly quickly as I need to sort meds so was wondering what you wise women think is best in your experiences

    Thanks so much all, here for everyone in any way I can help

    Take care all xx

    Offline klik

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #278 on: 1/03/18, 17:17 »
    Welcome, Lulu!

    I have some questions for you, but based on what you've said so far (and on my own experience) I'd recommend a mild-dose antagonist cycle after oestrogen priming--something like:

    previous cycle: estrogen patches starting one week before AF (on average, starting one week post-ovulation). Happy to give you more details about it, but if you happen to have endo (hopefully not!) then there are probably better alternatives...
    CD 3-7: 2x50mg Clomid (evening)
    CD 3 onwards: 225iu Merional alternate days
    CD10 onwards: indometacin 3x/day

    I'm not sure why your last cycle was cancelled. If they only manage to fertilise one of your eggs anyway, in practice it doesn't matter much how many mature eggs you start with...

    Which makes me wonder why only one is fertilising. How mature is mature? How big were the follicles at trigger, and what was your oestrogen? Possibly waiting a little longer to trigger might help. Also, have you been using ICSI? If so, how good is the clinic's lab at it?

    The oestrogen priming (or potentially norethisterone, or even BCP for a week or two) helps quieten your ovaries, which makes it easier for the follicles to all grow together when you need them to. So if you haven't been doing any priming or downregging before your short protocol, this is something to think about...

    Also, I'll wager you don't need these high doses. A mild dose will probably get you just as many eggs, and the ovaries won't have been stressed by so many meds while growing the follicles...

    In my case we avoided using an antagonist, because antagonists do make it harder for follicles to mature. We just watched LH like hawks--luckily on the above protocol it didn't rise appreciably for me before the follicles were really ready (ideally >20). But if it starts even thinking about surging, using an antagonist would be vital...

    That's just my experience--I responded quite well to this, and my AFC is like yours though my AMH is much lower. Some women do better on flare. It's hard to know until you try... but yeah, like I said, I'd focus on (a) some sort of priming or down-regging in the previous cycle, (b) lower doses and maybe using Clomid to try to recruit as many follicles as possible and (c) trying to find out why you only got 1/4 or 1/5 mature eggs fertilised...

    Good luck!

    Offline katkat2014

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    Low AMH / High FSH Cycle Buddies - Part 6
    « Reply #279 on: 1/03/18, 17:41 »
    Hey Klik, that's very interesting regarding your LH surge. So on none of your stimulated cycles did you take an antagonist? Did you do daily bloodworks? In your opinion, how high is too high an LH, I mean what indicates a surge? For example my LH is between 4 and 8 to start with. So the times I measured it around days 10-12 it was about 5-9iu, except for the month before last where it was 25iu and I ovulated the following day. But I know others (briss for example) goes much higher before ovulation. By the way, it would have been an immaculate conception, but AF finally arrived anyway. Great to know your next transfer is around the corner

    Welcome Lulu, there really isn't anything I can add to klik's mail. I agree with low doses vs high doses though too...

    Anna really sorry to hear this. Why don't you just pick the one natural egg in the meantime...while waiting for your AFC to go up? This way you give this month a go and as you are with R. clinic it doesn't cost the world...

    Helen, I think it doesn't matter when you do the transfer as long as your lining is good. Mine is usually thin so Id' be tempted to wait for a later in the month transfer,.

    AFM, AF arrived and quite annoyingly EC would most likely fall on a day I have an important workshop/meetings. Exactly one year ago the same happened, and I had to call in sick in order to make EC. I really cannot do the same this year :/ so not sure what to do as I was quite keen to do EC and ET this month, as the next 2 months it's not possible due to work trips. But I cannot take any holidays and to do EC or ET I need 4 days off. I know it is all so unpredictable anyway, so as usual have to play it by ear and get super stressed out as I will not know until a day before if it will be EC, ET or both or nothing this month!