* Author Topic: Low AMH/High FSH Cycle Buddies - Part 7  (Read 30401 times)

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Offline AlyDreaming

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Low AMH/High FSH Cycle Buddies - Part 7
« Reply #230 on: 25/06/19, 11:25 »
Briss - so happy that you got the all clear - that must be such a relief!! I too have had the egg quality talk from the doctors being of advanced age myself, turning the dreaded 45 in a few weeks :(.  But the hope of a viable pregnancy is what keeps my determination going.  I am on so many supplements since TTC (Ubiquinol, Fish Oil, Vit D, Methyl-folate, NAC....too many to name here) and keep finding research for new ones to add.  Also following ďIt starts with the EggĒ book and and have been on an anti-inflammatory diet (Auto-immune Paleo) since February which is extremely restrictive but have managed to stick to it - think Helen has mentioned it previously.  It has brought my TSH down from 2.8 to 1.3-1.4 in the last few months and I have managed to stop taking Levothyroxine. It hasnít made a difference to my TH1/TH2 cytokines but I was hoping to see the results in the egg quality this last cycle but sadly they didnít fertilise.  I sense that it was follicle size - I think you are right about follicle size being very personal - I personally donít believe that 18/17.5mm was enough as we had 100% fertilisation when the eggs were just 2mm bigger.  Interesting that on your natural cycle the dominant follicle doesnít get above 18.  I had a scan in May when my follicular phase went on for 24 days (normally 14 days) and the doc saw a follicle that was 21mm that hadnít ovulated - so maybe closer to 20-21mm is best for me.  The embryologist said the 0% fertilisation was due to the egg and not the sperm - which was excellent quality.  I had read that having too much LH in your system during stims can be damaging to egg quality especially for older women or PCOS, so I think the LH should be as low as possible. Mine was considered higher than what the doc would have liked especially as I was on Buserelin/Suprecur which is meant to suppress LH.

I have Stage 3 endo that was removed back in Feb 2017 but suspect it has returned given the pain is back.  There are conflicting opinions on whether endo affects egg quality but having that much inflammation in your pelvis canít be good for the egg environment.  I was going to have a laparoscopy before doing my next cycle but will now see how it goes with the new clinic and doctor.  If I get 0% fertilisation again, I will go ahead with the laparoscopy. It seems to have worked for MSJ.

Congrats on owning your own home and welcome to SW London - although not sure where you were living before.  We love it here!

So sorry youíre feeling down about not having a job.  I was made redundant last year in the middle of my IVF cycle so I really feel for you. I found most new employers are very understanding about redundancy and I hardly know of anyone these days who has not been made redundant at least once. 

Youíve been through so so much in the last few months so allow yourself some time to recover and settle in your new house.  Maybe you can have a few stress free cycles whilst youíre off work - I decided to have the summer off when my last contract finished so I could focus on IVF without the stress of a full time job.

Howís the 2WW going Catlady?  Hope youíre managing to relax.

Hope everyone else is well. Anyone else cycling in July?  Iím still on Cyclogest until my doc appointment tomorrow and will start stimming for another round of embryo freezing when AF arrives  - possibly early next week!

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    Offline CatLadyTTC1

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #231 on: 25/06/19, 12:06 »
    Hi aly. Wow what a journey you are also on. How amazing for you all. Really interesting to read so many positive comments and people being proactive.

    Afm my 2ww is actual torture. I tested yesterday afternoon with FRER and have a faint positive. OH is now worrying me as I didnít realise HCG could still be in my system. He doesnít know I tested or anything thatís going on in my mind. I now have back ache and cramps and all the signs of AF coming. Weíve agreed to test on Friday as we have some FRER coming from amazon today. My calculations are that EC was 2 weeks ago Thursday and therefore af would be here Thursday. Iíve never had a 2 wow like this. The clinic in Cyprus want us to have a blood test on Monday. OTD would be Sunday but no where will be open Sunday. I live in Cromer so having to research everywhere where I can go for a test. Someone said baby scan places do blood tests? Google isnít actually very good in situations like this haha.

    Hope everyone is well and keeping positive x

    Amandacatherine

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    « Reply #232 on: 25/06/19, 13:22 »
    Testing early is a nightmare as it happened to me the trigger was in my system and was showing a false  positive. It was a trigger if 1500 and it was there for 14 days, so was a large amount. Maybe wait till tomorrow and try again.

    Offline CatLadyTTC1

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    « Reply #233 on: 25/06/19, 13:28 »
    Hi Cath. Iíve just tested again with dilute pee and thereís still 2 lines. Faint line but still a line.

    Iíve now got the constant need to pee. As someone said I had 3 embies and if one hasnít made it I guess I would expect a bit of bleeding. I had a tiny amount of spotting which has also gone now.

    Iím actually driving myself crazy and I canít stop. I thought testing would help, it doesnít help. I took 10,000 chroninom or some spelling like that.

    Your insane cat lady! 🤣🤣

    Amandacatherine

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #234 on: 25/06/19, 14:00 »
    I know when you start you canít stop and to be honest I donít advise stopping testing after starting as that will really drive you mad. Well if you are 14 days past the trigger you should be in the clear and it is a positive but if you are less then that then you have to allow some doubt that it maybe the trigger. I know how nerve wracking it all is, I think it is the worst part of the whole IVF process, so hang in there!   

    Offline AlyDreaming

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #235 on: 26/06/19, 11:17 »
    Oh Catlady!! That is torture!! I agree with CathA that once you start itís even worse to stop.  How are you today?  Is the line getting any darker?  Iím crossing fingers for you that at least one of the embies is snuggling in there.

    Offline CatLadyTTC1

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #236 on: 26/06/19, 11:46 »
    Hi aly and cath. Thank you for taking time to reply to me. It means so much.

    We have tested again yesterday afternoon and still there are 2 lines. I just wish it was a strong 2 line and that everything was normal and progressing and we all knew this and etc etc etc haha. Iím in bed rest atm and been sleeping well. I am still spotting but this is more black blood when wiping. I donít know if the progesterone injection and cyclogest would keep af away. I still have cramps in fact theyíve not really gone since the whole ivf egg collection process. My elastic band belly feeling is back as well. I donít know what to think. Iím trying to find somewhere in east anglia thatíll do my bloods. Thatís my next obsession. Need to book in for Monday. I think the clinic want a test result no matter what. Still find it hard to lay on my belly as that makes the cramps worse.

    Who knows whats going on. I guess I just have to keep the faith.

    Offline MSJ

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #237 on: 28/06/19, 15:28 »
    Hi ladies I'm glad to be back and thank you for your well wishes. My update is below.

    Alydreaming - I'm sorry about your last cycle and lack of fertilisation. I had the same last time and it was a shock as it was the first time that's happened to us. It looks like you've had a few natural pregnancies which is promising. Were they all after your surgery, did you have excision? The only 2 times that I've had BFP was after surgery and they were both natural. The first surgery was ablation (burnt off) and was guaranteed it'll come back. My second surgery was excision (cut out) so I'm hoping it'll stay away for longer. Do you have endometriomas? If they are over 4cm I think it may be worth removing them, but of course it'll compromise egg reserve.  I'm wondering what were the causes of your miscarriages, did you get any of them tested? If it is chromosomal abnormalities I hope you find your golden egg soon.

    Cat lady - all the best for the 2 week wait. I always found this to be the hardest part, hope you're managing to stay sane.  3 embies to transfer is good going and it must have been really hard to let the other 3 go.

    Katkat - how is the jury service going? 7 weeks sound like a really long one! I hope it's an interesting case at least. I'm glad they'll stop the trail for 1 day for your fertility treatment that is really good. Regarding fibroids I think it depends on where it is and it's siz, whether it is growing and whether it effects the uterus in any way. I do also have a fibroid. It has grown a bit over the years, all doctors I've seen so far have said that it'll not effect my fertility in any way due to where it's located,(posterior I think), as it doesn't effect the shape of the uterus. If it does in the future then I may need to get it removed, but I don't need to worry about it for now. So as some of the other ladies have said it may be worth getting a scan to confirm this.

    Hopeful81 - I'm sure your blood results don't sound too bad on this board as many of us have high fsh. With regards to DHEA, I know it works for some and not for others, I had a really bad experience with this. It made my endo pain really bad and had really bad bleeding with massive clots. I mean like science fiction bleeding with clots, so I stopped it. If anyone wants my DHEA I have leftover happy to send it (free, I won't be using it again)

    Odashwood - I'm so sorry to hear about your pregnancy. Fluctuating HCG levels and knowing you're  pregnant but will it work or not limbo is the hardest thing to go through. See below update.

    Briss- I'm glad you got the all clear from Dr J. I'm always also getting pains on both my sides, pre surgery and still post surgery, I'm really not sure what it could be. I know post surgery it can take a while for the pain to subside. Also, congratulations on moving to Wimbledon, having a lovely new home is wonderful, so take time to enjoy it. Regarding blood tests in Wimbledon, when I lived in west London I went to The GP surgery in Wimbledon for quite a few blood tests, they were quite competitive in price too, however, you have to pay a one off gp fee each time you go I think. It's very near the station. I hope the job hunting isn't too stressful, can you afford to take some time off? I've also quit my job and am not looking forward to the job hunt.

    Chini  - thank you so much for your advice on endo/adenomyosis diet. I've been doing the endo diet as much as I can, although when you're invited to someone's house for dinner or dos like weddings, it's quite hard trying to stick with it, I feel like I am a really awkward guest, and chocolate is a bit of a weakness for me, but I try as much as I can. I haven't tried any of the other supplements you've mentioned though, I'll try and look it up.
    I'm so engrossed in supplements when it comes to ttc but was not sure at all what I should have done when I fell pregnant. Do you keep taking those supplements?
    I'm also really sorry to hear about DH's mum and all the delays. I totally get what you mean by trying for nearly 3 years not been able to do many rounds. I've only ever done 2 fresh cycles and 2 banking ones in 3 years. How's your treatment with Dr G going? I think we may have similar issues as I also have high antithyroid antibodies even though TSH is within normal range, so Dr G has put me on small,dose 25 mg of thyroxine.
    I hope your cycle in July goes well, keep us updated. I also noticed you shared a link for doctors best ubiquinol, do you have to pay duty for this?

    Babyhopeful - really sorry to hear about your dads cancer and everything you've been through. How are you doing?

    Helenbeau-  I hope you manage to get some clarity on your uterine issues. Have you ever been seen by an endo specialist? The problem I find is endo specialists aren't fertility specialists and vice versa. If you choose to go and see and endo specialist a nook doctor would be wise.

    Shady/klik- I hope all is going well. Shady so glad you've been able to tell few people it must feel very real now. Klik do you have long left?

    Sorry if I've missed anyone..

    AFM - it's been a bit of a rollercoaster ride the last few weeks. After my BFP, I went to see ARGC who monitored my HCG levels. At first it was good news. First result was approx 400, next day it went up to 600, 2 days later it went up to 800. They put me on clexane and cyclogest, and 10 mg of predisolone. I also had my immunes tested and when my HCG wasn't increasing well, they upped the predisolone to 20mg and also gave me intrapillids. I was a little worried at this point. I could feel in my body something wasn't right that I maybe overdoing things. I was extremely fatigued and I stupidly carried my heavy laptop home with me. On the way home it felt like it was too much and felt like I shouldn't be doing this. My next HCG 2 days later went down a bit to 762, which wasn't good news. I had a scan a couple of days later where they thought they saw a sac, but my HCG had gone down even more to 569. Therefore the likelihood of it being a viable pregnancy was very low. I kept getting my bloods tested, but HCG went up again to 629 and then a couple of days later 609. Then they got worried it could be ectopic which made me worry even more. Since then I've been referred to the early pregnancy unit and I've had a bleed. At the scan they couldn't see anything so they suspect it was a miscarriage and my HCG has dropped further to 300. I need to go back to bloods tomorrow and hope it'll keep coming down.

    Sorry it's not happier news, my excitement of a BFP was short lived. So I think Ive miscarriage at 6.5 weeks. I thought I would be ok as it's so early in the pregnancy and have been trying to be ok, but I am actually heartbroken.  :'( The whole thing being in a limbo is really hard not knowing is it viable or not, is it ectopic. I've been up and down and all over the place that my colleagues have noticed and keep asking me if I was ok. I also feel guilty as I've just taken time off for surgery a few months ago. My boss wasn't so sympathetic. I told her initially what was happening which was probably a mistake as she couldn't understand why I would be upset and it was clearly a burden for her, instead of giving me any kind of compassion she put pressure on me to finish some work, which was basically checking her work she'd done incorrectly. So I have also quit my job, but I am on 3 months notice unfortunately and I just don't want to be there.

    This journey, each hurdle really does take it out of me. I don't know how we all manage to find the strength to keep going, but I'm sure I will soon.

    If there's anything I've taken from this is I've learnt my endo really has impacted my fertility as both natural and only BFPs have been after surgery. I'm hoping due to the type of surgery I had this time that my endo will stay away for longer this time. I'm just not sure the reason for the miscarriages although chromosomes could be the reason.

    With regards to supplements I've totally stopped taking anything until my miscarriage has finished. Would you do the same? And when I learnt I was pregnant I only took prenatal, folic acid, methyl factors, vit D and omega 3 fish oil and probiotic tablets. Is that what you would take?
    I also had a horrible painful cyst on my vagina (sorry tmi) for quite a few days, anyone else get this?

    Offline klik

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    « Reply #238 on: 29/06/19, 06:16 »
    Hi, gals. Sorry for the silence--it's been busy but also there's a kind of withdrawal that happens in pregnancy, at least for me...

    MSJ: Thanks... Not long left, no--6 more days til due date... I was really happy to hear about your BFP, and I'm very sorry about this heartbreak... Is your mind at least finally at ease that it's not an ectopic? I'm not sure why they suspected that, as the hcg has been coming down, not going up slowly... But it's important to know for sure. I'm so sorry... How long after surgery did you get pregnant? Maybe you'd benefit from implantation cuts? Two m/cs is not atypical, in this journey... I had two myself, before my pregnancy, not counting any chemicals... I know Shady had two, also. I hope it's third time lucky for you, next time... In the meantime, I'm so sorry--please take the time to heal, and make sure the people around you are good to you. It's just too sad... I'm really sorry...

    odashwood: I'm so sorry... Miscarriages are just too hard to bear... I hope you have time and space to mourn, and that you're surrounded by kindness. I'm so sorry... It's a difficult loss to bear... Good luck with the surrogacy cycle, if you do decide to follow that path!

    CatLady: it's certainly looking good so far--good luck! If the second line was from the trigger, it should have been getting lighter and lighter every day, which doesn't seem to be the case. Have you found a place to do bloodwork yet? Good luck! I hope this has really worked for you!

    CathA: hello...

    AlyDreaming: welcome! I'm so sorry about no fertilisation--I echo Briss... I wonder whether your follicles were just triggered too early. It's a suspicion I have with a number of clinics, who err on the side of caution rather than risk losing the follicles. Also, your LH did not seem high to me--why do you consider it high? Anyway, I'm simultaneously encouraged and puzzled by the number of BFPs you've had... I'd be wondering what those are about... It could be chromosomal, sure, but that many? It increases the uncertainty, really, which is one thing that makes this journey so tough... Hang in there, and best of luck...

    Briss: Thank you very much for the wishes... I'm trying to nap whenever it's remotely desirable, because night time is not at all a guarantee of a nice long sleep... I'm working a little bit, as my hours are super flexible, but I've wound down a whole lot... I'm super happy Dr J gave you the all-clear--is the pain improving? I'm also hoping that this enforced break from TTC will have allowed your body to recover and will give your next attempt a better chance, whenever it might be... Congratulations on the move, and I hope the family vibe is somehow catching and that you end up being one of these women with 1+a bump. And well done on becoming a homeowner! I'm really sorry about the whole job situation--unemployment is really low but I suspect that's not the case for the higher-paying jobs which are more Brexit-sensitive. I hope you find something soon, and that your move to your new house is the beginning of things slotting in for you: pregnancy, job, harmony at home... I'm so sorry you were struggling with DH, but I'm glad to hear you've turned a page--long may it continue! Good luck--hoping for continued good news from you!

    helen: how are you? Did you tell us how your aquascan went? I hope you're ok... I have in mind someone I know who switched to DE after a number of failed OE cycles and a couple of m/cs, and her first DE experience also ended up in a M/C. She sorted out her thyroid function (I understand yours is good), transferred two DE embryos, and ended up with lovely twin boys. Your body so wants to be pregnant--I hope it can, and for the full nine months next time... My fingers are really crossed for you...

    katkat: have you transferred? Will you? have you figured out where you are in your cycle? I hate it when cycles which are normally regular act a bit crazy--I find it super destabilising, psychologically... I hope in spite of its strangeness, it's actually turned out to be a good transfer cycle for you--good luck!!! Really hoping to hear good news, soon--I'll keep my fingers crossed! And I hope the trial is, at least, not boring!

    Shady: thanks! I'm loving reading about your story--everything is unfolding so beautifully... Long may it continue! And it really looks like in a few months, you'll have a perfect, healthy baby in your arms! May we all have this fate, and soon!

    Hopeful_81: It was good to read an update of yours, though I'm sorry you seem so downbeat about it... I know very little about DHEA, except it does seem to help some people but, then again, a lot of people do seem to react quite badly to it. But if your testosterone levels are low, it might be something to look into... I think you probably already know this, but I think testosterone is a precursor to oestrogen, so taking DHEA might make your endo flare up... Nothing is simple in this journey. Anyway, I really don't know much about this... Re. FSH, though, I really wouldn't be spooked by an FSH of 18.9, especially when paired with such low oestrogen. Oestrogen dampens FSH, so if your oestrogen is that low, your FSH will almost inevitably be quite high--and frankly 18.9 isn't even that high. I think the question really becomes, why is your oestrogen that low? Usually it would be because your follicle growth has been suppressed for some reason (sometimes it happens naturally) and then it's just a matter of time (days, probably, in this case) before your follies start growing and your oestrogen increases and your FSH decreases. This clinical picture doesn't seem at all discouraging to me... I'm wondering about your doctor--I have the impression s/he has painted a more dire picture for you than reflects reality... I've never heard of SHBG but unless you're working out, like, 2+ hours/day, I'd be gobsmacked if the exercise you're doing is bad for you. I'm feeling quite protective of you, right now, because it feels to me like you're in a vulnerable place, easily hurt, and your doctor has been quite careless and overly pessimistic/critical. My sense is, you're still more than capable of producing beautiful eggs that produce beautiful embryos. Have you embarked on your transfer cycle yet? Good luck--gosh, do you deserve some luck!

    chini: thank you... Re. norethisterone, I just took the typical pre-cycle dose (one tablet in the morning, one in the evening, but I can't remember what the dosage is per tablet). I started after I was sure I'd ovulated (in my case, I started the day my basal body temperature surged), and I took it for 11 days. I tested with an FRER on the 12th day and it was positive, so I went to my clinic for blood tests--my progesterone and oestrogen were woefully low, so Dr Ozturk put me on 2xCrinone and 2xCyclogest per day (again, I forget the dosage but afaik it's the typical dosage prescribed by clinics.) I started the crinone and cyclogest the day after my last norethisterone, so I was never without progesterone supplementation. After a few days i added 2 Evorel patches as well (I think each patch delivers 100mcg/day), as my oestrogen was just super low. I'm sorry you've had just so very much to deal with--it's truly overwhelming... I hope you're doing ok... I suppose you must have started downregging by now--best of luck! I hope this is the cycle for you!

    AFM: counting down til next Friday, which is exactly 40 weeks. They don't like letting over-40s go above 40 weeks (they don't trust our placentas) so that's a pretty hard deadline. Very difficult to wrap my head around, but I suppose when the little guy is out in the world, that new reality will set in very quickly!

    Offline MSJ

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #239 on: 29/06/19, 13:37 »
    Klik thanks for your kind words. I got pregnant about 6 weeks after surgery. Maybe it was too soon. Glad all is going well and good luck for the next 6 days and the birth


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