* Author Topic: Low AMH/High FSH Cycle Buddies - Part 7  (Read 30412 times)

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Offline katkat2014

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Low AMH/High FSH Cycle Buddies - Part 7
« Reply #250 on: 7/07/19, 11:58 »
Yeah briss, I knew you'd travel anyway ;) good luck for EC..why don't you ask the person doing EC what they think of the pain and if they can have a proper look as well. By the way what thickness does your lining have on these natural cycles (like on Friday)? How much P will you take after EC and when will you start taking it?

Hope.you got a direct flight to Brno. I nearly missed my transfer and was so so so stressed last time. I flew to Prague and then the 2.5 hour coach transfer the next morning took over 4 hours due to traffic jam due to building works. I called R. Every 30 minutes to say am so sorry if they can please wait as I still don't know what time id arrive. They only kept the clinic open for me. They also never checked if the test tube was empty after transfer and everything was in a rush.... Not a good start. And then it was bfn and I couldn't help but wonder if the fibroid had anything to do with it after all, regardless of it being so small.

Afm i checked my hysto report from April 2018 and it says all clear no fibroids or anything else. And then I looked at all my scan pictures and I think the lining started to look a bit squashed from about the start of this year. What if I transferred my 2 blasts into a suboptimal lining?! I only have one blast left and no energy left to do something that doesn't seem likely to happen. Yet I cannot help but wonder if this tiny fibroid had anything to do with my last failed 2 transfers. I hope that Dr M will rule any issues out tomorrow! Having bad eggs, high antisperm antibodies and a thin lining really is enough (together with poor sperm). At least can I have a normal uterus please!

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    Offline Briss

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #251 on: 7/07/19, 22:31 »
    Kat, im very sorry about your bfn. Its heartbreaking! sorry I can't help with crinone I never used it. It seems to me if you started bleeding on it then maybe it does not work for you that well? Although 14 dpo is about right and enough time to allow implantation. Is it considered generally better than progesterone? Let us know how your scan goes and what they say about the fibroid. Its really hard when you are getting conflicting advice. I'm generally in favour of less is more but in your case I strongly believe that implantation could be the issue rather than egg quality but I'd get more advice before doing anything. I'd hold on to your last embryo if I'm honest until you get to the bottom of this fibroid business.

    My lining is usually quite thick. On friday it was 12mm but usually its anywhere between 9-13 on natural cycles going up to 14mm on stim cycles.  I noticed that the higher my estrogen the thicker the lining. Having said that after ovulation/ EC it goes down to around 8-10. But the lining is not just about thickness but also receptivity which is much harder to measure. I am convinced my lining was not receptive the entire time I was BF. Of course I have no way of proving it except that as soon as I transferred a decent looking embryo after I stopped bf it tried implanting.

    On progesterone, these days I rarely get to transfer so I only start progesterone once fertilisation is confirmed ( next day after egg collection) cos that usually means I have reasonable chance of transfer. I do either 100◊2 of German/Czech three times a day or two cyclogests a day. I noticed that increasing synthetic progesterone does not really improve my levels. I suspect my pregnancies were held by my natural progesterone to the large extent. That's the reason why I hesitate to do another long protocol dvdn though if lead to bfp. Despite taking usual amount of progesterone my levels were unusually low.  And I think its also true for all other things that your body is supposed to be doing to support a pregnancy.

    Sounds like you had a horrendous trip to brno last time.  I know stress could be contributing but personally i believe stress concerns are over rated.  Your body can handle it and if the embryo is trying to implant it will give him priority over your own health. A stressful couch ride will not stop it. I'm constantly surprised how many women get pregnant in war zones where stress levels are much higher. I love Brno for being so flexible! Amazing that they waited for you.

    I took a direct flight to brno even though it was not cheap.  Last time I went via Vienna which is a good option as the couch departs right from the airport but it still takes ages and I wonder if such a long bus drive might have contributed to early ovulation.  The day before EC I'm usually very careful trying not to move much to make sure the egg stays put but that might be naive of me to think i have any control over it. Last time I went to brno we missed the egg the follicle collapsed before EC but I know it was the right day judging by my hormones and follicle size.  This cycle is similar only I've triggered a day early I think . My cycles changed so much last year that I no longer feel any confidence in what I'm doing.

    Munich always checks that the test tube was empty after transfer, I can see it on the screen. not that it gives me any comfort. It's funny you mention it cos half the time I have doubts whether the embryo actually made it inside the uterus. Even though they do a scan right after to confirm it's there.  I still doubt if the transfer was not perfect.  Last time I was convinced the embryo lost its way cos I felt the catheter pulled out. Obviously I could not be more wrong cos I had a bfp. On my very first ivf I was sure I peed the embryo our after transfer.  Funny right?  I hate full bladder transfers cos I can't hold it I'm in agony if I need to pee. Holding it for ages while waiting for transfer and i had about 5 min after then i ran to the toilet and peed so hard like my life depended on it. Sorry Tmi.  Anyway it was a chemical so obviously the embryo stayed put. But still any not completely perfect transfers make me doubt the outcome.


    hopeful, I'm sorry the 3rd embryo didn't make it. I'd also want to transfer whatever they cant freeze but in this case where is no division in 24h that would most likely mean the end so I wouldn't want to take post transfer medication and go through two with virtually zero chance of a bfp. Well done on 2 good quality embryos!! Great result! Enjoy your month off, you have done amazingly well.

    MSJ, I'm so sorry! I don't think there is anything you could have done. I think when your hcg went from
     600 to 800 in two days was probably the beginning of the end and nothing could make a difference at this point. I'm impressed that  ARGC were trying everything to give this pregnancy a chance.  I don't think you could have done anything more. I know how hard and heartbreaking this is but try to focus on the positive- your body wants to get pregnant and it can! I'm convinced you are very close to a viable pregnancy.  I'm sorry about your job situation, your boss is just awful for putting such pressure on you at this time . It's actually positive news that you discovered how endo is affecting your fertility at least now you know how to make it better. Your vitamins sound good. I'm not sure about vaginal cyst.  I've heard of vaginal polyps which I understand is easy to remove.


    Catlady, I hear you on side effects of ivf.  I can't help but think my current pain on the left is a cumulative effect of so many egg collections. It would be reasonable to stop. But somehow I just can't seem to accept defeat.  As I said I believe it's a genetically engineered drive that is just stronger than my own will. I'm so pleased you got bfp! A huge milestone.  I so hope this is the beginning of a new life for you so you could get a bigger house with a garden and finally move on with your life. Did you manage to find a place for a blood test? I usually use path lab in central London but they are closed on Sunday. Wishing you every success with this pregnancy!

    Alydreaming, your vitamin list looks good. Well done on following such a restrictive diet. I'm amazed you managed to bring your tsh down by dieting!! Trully inspiring. I think you are right about endo, I didn't appreciate how much it can affect the egg quality. I hope you get a better fertilisation result on your next attempt.  I'm also thinking that it might be worth trying ivf now as I'm more flexible to travel without the job. SW is growing on me I almost wish we moved here sooner , it would have been easier to manage things with a baby but it's a big harder with ivf as everything is quite far now.

    Btw found impossible to book scans in Wimbledon, i have ultrasound direct at my doorsteps but you need to book 1 week in advance same for privatw gp clinic that does cheaper scans but again upheld have to book at least 2 weeks in advance. Not helpful at all so I have to travel to the city for scans and still use path lab for bloods. Lots more travelling.

    Odashwood, looks like you have done quite extensive research on surrogacy.  Well done. You'll be our resident expert on this. I have a few friends who are looking into this option but the decision is hard.  They should probably do what you did and actually meet the reps. Best of luck with your plans!

    Sorry ladies I haven't managed to read all the updates yet , will catch up tomorrow

    Offline katkat2014

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    « Reply #252 on: 8/07/19, 18:49 »
    Hey briss how did it go? You seem to take about the same amount of P than me then as one crinone is 600-800 progesterone apparently. I did start on a lower level though as last time my P was too high at transfer. Do you usually take a double trigger for your EC and did.you give up on the cetrotide these days? I have a feeling.you said that sometimes you don't even trigger for your natural cycles at all... You have an enviable lining! It must be the high estrogen as mine is usually fairly low even when follicle is mature. Maybe around 1,000. Yeah I definitely didn't think that stress plays any part, was only just saying as everything afterwards was so rushed. I hope.you got the egg!

    Afm so I had my scan with Dr. m (Dr jurkovic colleague). He said that he thinks it's mild adenomyosis and not a fibroid! So I have his opinion. Then I have gennet's who say it's a fibroid and to remove it. And I have Reprofit's who say it's a fibroid but small and to leave it in. Then a couple of sonographers over the last year mentioned it's adenomyosis, and one that said it's a fibroid  ;D in any case, if it was adenomyosis then nothing much I can do and Dr M said it's mild..if it was a fibroid then he said to leave it in as just about 2cm in size. Whatever it is it does seem to distort the uterine cavity a little bit.

    He also said with the many transfers I had he cannot imagine I didn't have a normal embryo in the mix but that for whatever reason didn't implant. He also said my era test was useless as I have never done a medicated FET which is what I tested for.  Now does anyone think I should go ANOTHER ERA based on a natural lining?! I only have one embryo left plus if I moved on to DE I have no choice but transfer into a natural lining. But I have NO money for anything anymore!

    It's only day 8 and I have a 15.5mm follicle which is atypical for me and my lining is not in line with it at 3.5mm..or rather my follicle is the wrong size for day 8! So no transfer this month unless they both line up with each other end of the week. Not sure if I should just give up on this month or waste more money on scans.

    Offline Briss

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    « Reply #253 on: 9/07/19, 20:18 »
    Hi Kat, we got the egg but the follicle was only 15mm basically almost the same as 3 days before collection.  the egg was mature but did not fertilise probably because  of the size and lack of growth the egg was not good. I used ovetrell for trigger this time and these days i do use trigger. I used to be able to time EC without the trigger just based on my monitor and catch mature eggs. In fact that's how our daughter was conceived. but these days my cycles are all over the place and i no longer able to predict the right time for collection. I did not use progesterone this cycle cos there was no fertilisation.

    I have to say reprofit's egg collections are hundreds times easier compared to Munich. I felt virtually nothing.  In munich I almost jump on every puncture cos its a seriously painful hit every time. They seem to use very different methods . my ovary is actually doing better after collection so maybe the pain is really due to follicular growth although during the scan i could notice some parts of the ovary were very sensitive to touch.

    I also think that estrogen and lining are connected. My lining could easily be explained by higher estrogen levels although when i was BF my estrogen was lower below 1000 but lining was still similar to what it's now.

    adenomyosis does not sound too good. as far as i managed to work out it does affect fertility and can make it harder to get pregnant. can you do an MRI to determine whether it is in fact adenomyosis? I would see somebody who specialises on this because i agree with what he said i.e. with the many transfers I had he cannot imagine I didn't have a normal embryo in the mix so i'd focus on your lining for now and continue collecting.

    depending on your estrogen levels the 15.5mm follicle could actually be a simple cyst.  having said that i would not transfer your last embryo until the lining is sorted.

    Offline odashwood

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #254 on: 10/07/19, 09:56 »
    Hello Girls, how are you all?
     Kat, how are you feeling today? Sorry for your bfn, dear(( What have you been doing these days?
    I was ready to book a flight for my consultation and got to know that my clinic is closing for annual sanitation so I have to wait a little bit more. I feel like I'm wasting time(( Waking up every morning I catch myself on thoughts about how I can be useful for other people and decided to go in for charity but haven't decided yet what kind of. What do you do to distract yourself from all this stuff?

    Offline AlyDreaming

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #255 on: 10/07/19, 15:10 »
    Briss - sorry to hear that your egg did not fertilise.  It seems to be such a fine balance between getting it mature enough to fertilise and waiting too long. I have to applaud your determination flying out to get there in time!

    Katkat -It must be so frustrating to get conflicting advice/opinions! I agree with Briss that itís better to wait until everything is more in line to transfer.  At least, it would be good to resolve the possible fibroid/adenomyosis. Remind me if you have any immune issues and if you have had any immune treatment. Iím thinking your Dr is right - it canít be all bad eggs - there has to be some other reason for implantation failure.  I donít know anything about ERA or FET having never gone through it so sorry I anít offer any advice on that.

    Odashwood - I find waiting time to start a cycle very difficult - I was due to start cycling in Jan, then Feb etc but due to one thing or another only started in May.  I kept myself busy by using the time to meet up with friends, cooking and yoga but volunteering for a charity would be another good option.  I hope the time flies and you get to cycle soon.   

    MSJ - thank you for your good wishes. Iím currently cycling with Lister with Dr Thum due to the immune issues.  For my endo and ERPCs, I have seen Mr Colin Davis who I cannot recommend more highly.  He also does IVF and I did my first 3 cycles with him and got 100% fertilisation and transferred 2 back in each time - sadly all ended in MC. I have no blasts as the 2 leftover from the first cycle arrested at day 4.  Iím hoping that the MC have been due to immunes. Now that I am having immune treatment before the cycle starts,  Iím hoping for a lasting pregnancy.  Did you get any answers on whether your pain should have gone away?  It doesnít sound right to me that youíre still in pain so you should definitely get it checked out.  Iíve heard of Dr Vidali - let me know how your consult with him goes.  He was working closely with Dr Braverman who also specialised in IVF for endo patients and they developed a supplement called EndoOptimize which I will link below.  I have been taking all the ingredients separately for the last month so fingers crossed it makes a difference.  https://www.preventmiscarriage.com/endo-optimize-supplement.html

    AFM - Iím on Day 7 of stims and I was amazed to see that I had 5 follicles at baseline - havenít had more than 3 for the past 3 cycles.  Even more surprising is that they are all growing and today they were 17, 16, 15, 14, 14mm.  They have grown very fast this cycle (4-5mm in 2 days) whereas usually itís 1mm per day and I stim for 13-14 days.  The nurse is already talking about triggering tomorrow (day 8 of stims) or Saturday (day 10). Iím nervous to trigger too early and then they donít fertilise (like last cycle) but Iíve heard too late is bad too due to harder shells (?). My 100% fertilisation cycles has been when I trigger at 19/20mm.  They donít usually schedule EC on Sundays so not sure that triggering Friday for EC on Sunday is an option.  I pushed for a scan tomorrow so we can see how much theyíve grown but if they continue to grow at the same rate the lead might be at 19mm tomorrow.  Looking for your collective advice on the best way forward.  Would you wait or trigger earlier?   

    Offline katkat2014

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    « Reply #256 on: 11/07/19, 15:52 »
    Hey Aly,  I hope your scan today was helpful to decide what to do. I really don't like it when clinics are closed on a Sunday as looking at your numbers then that would be the perfect day for EC. I really am not sure what to advise as everyone is so different, for example on stim cycles mine need to be on the larger side ie minimum 19mm to have a mature egg.

    Briss I am very sorry to hear there was no fertilisation. Reprofit are great when it comes to the procedure, last time I didnt even realise that they had already done the ET, I didnt even feel the catheter going in. In regards to scans, I don't think wasting any more money on this would be of any help. If it was light adenomyosis then you can't do anything about it anyway apparently. I may have another scan to see if my lining improved but I have not much cm or ewcm (although opk light positive) so I cannot help but think that this egg isn't good, low estrogen and hence bad lining. If the lining looks good I may go ahead with transfer. Maybe.

    Odashwood, the constant waiting is the absolute worst with IVF. Thanks for asking feeling ok actually. Just very scared that this next cycle won;t work.

    AFM sorry am asking this question again. What level of progesterone does your clinic deem ideal on transfer day? I guess there could be different 'ideal levels' depending if you did a fresh stim cycle, a natural cycle with or without trigger or a medicated FET.

    Offline CatLadyTTC1

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    Low AMH/High FSH Cycle Buddies - Part 7
    « Reply #257 on: 11/07/19, 16:46 »
    Hey kit Kat xx thereís a few ladies asking that question on July/August cycle buddies xx maybe worth asking there xx

    Iíll catch up with you all this evening I promise xx

    Offline katkat2014

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    « Reply #258 on: 11/07/19, 17:15 »
    Thanks Catlady where exactly do I find this thread, is it under low amh? Hope.your cycle turned out well !

    Offline CatLadyTTC1

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    « Reply #259 on: 11/07/19, 17:49 »
    Hiya in cycle buddies. Think itís also in FET chat. MissL is becoming very knowledgeable on the subject xx itís trensinf at the moment :)

    Thank you kitkat. It has turned out well at the moment! Iím pregnant and in the wait for a scan to check how the bubba is coming along xx thank you for asking.