* Author Topic: Low AMH/High FSH Cycle Buddies - Part 8  (Read 24811 times)

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Offline Pritamin

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Low AMH/High FSH Cycle Buddies - Part 8
« Reply #240 on: 29/01/21, 15:48 »
Hi all,

I wrote a long post then it was lost.
I keep dropping off threads and climbing back on other ones in the hope that we will be able to do the cycle but I face  delay after delay. We last started a fresh cycle in October which we had to abandon because follicles grew at different rates due to cyst. Then it took my period 55 days to come then waited another month and consultant said to try naturally (as if!!!). Then In January the consultant saw 3-4 follicles and a cyst so decided to wait another month and took estrogen for 7 days to make sure the cyst emptied with next period.
I came for a baseline scan today and the cyst is collapsing (yay) but the consultant didnít see any follicles and said that my ovaries looked very quiet. This was the first time that there were no follicles at all. I know that things can change from cycle to cycle but Iím worried that this is it. She asked for an fsh test which weíll have on Monday and we can decide based on that whether to stop this cycle or carry on. I know in my heart that this cycle will be binned but I canít help but thinking that this is the end of road for us. My fsh in August was 13.6 and she said if itís 30-40 then we need to start thinking about whether we want to carry on. I just donít see how it could
Change that much in just a few months but then Iíve had low ovarian reserve since I was 35. I mean I had it before but it was only discovered then.

I donít know what Iím looking for with this post, guessing some positive success stories.

Anyone knows any clinic that specialises in older women with low ovarian reserve and high fsh and have had solid success rates?
Iím turning 41 on Tuesday.
Or which clinic is the best for donor egg IVF in uk or abroad? I donít even know if Iím ready for DE but I feel we might need to explore that option.

Sorry for the negative post, Iím just a bit lost.
X

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    Online queenie123

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #241 on: 30/01/21, 10:54 »
    Hey - Do not dispear.

    At 32, my d3 FSH was 26, AMH 2 and I was told to go straight for donnor.   I got it down to around 12 with lifestyle changes, exercise and suppliments. 

    I had months (particulallry when I had taken some Oestrogen or other mild down-reg) where my ovaries looked like they had nothing on them until day 5-7.  And I never recently made more than 1-2 eggs at a time, we went for quality over quantity.   IVF Serum (Athens) got me my OE bfp, but it took so much work. 

    It sounds like you need to try a diffferent and probably more natural approach.  Good luck!

    Offline Pritamin

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #242 on: 30/01/21, 11:15 »
    Awww, congratulations to you Queenie!!
    My very first ivf with ARGC was natural cycle and then I went to Nhs and started on 300 gonal f and 150 menopur.
    Out of those embryos weíve had our daughter.
    Last time I was on 375 menopur which we had to abandon and this time the consultant told me to start with 300 menopur which is a drop from what I was previously on but Iím starting to think:

    A) we need an even lower dose like you said. What protocol were you on with your successful round?
    B) maybe time to start thinking about DE but Iím worried it takes such a long time

    Are you happy with Serum? How did you find the travel back and forth? Can I ask how much a round approximately costs with them including consultation, drugs and travel / accommodation?
    Iím also worried that things will change with Brexit like they wonít be able to prescribe mediation to pick up here in the UK.

    Sorry about all the questions.

    Offline Saltysea

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #243 on: 30/01/21, 12:00 »
    Hi Pritamin

    I think our ovaries have a lot in common and I definitely have had no follicles at baseline as well - but under stimulation something always did grow (although few - as to be expected with my AMH).
    I couldn't recommend the Lister highly enough for people in exactly our situation - I found them after doing copious amounts of research and I have found all their treatment decisions to be in my best interest and most likely to result in success based on current available evidence. I also like the fact they stick to the things that really matter and don't waste your money and energy on a lot of the other non-proven treatments/recommendations. I feel they stick to the proven basics but do those well consistently, they always get all the eggs at collection and I have been pleasantly surprised how many percentage-wise made it to blastocyst (you can see my story in my signature). I travelled in and out from another country to go to them and I never regretted it.

    That all being said, and I really hope I'm not being negative or upsetting you, I seemed to be more in your situation when you were successful the first time around. My plan was to give it 3 attempts and then move on to DE (at 37 years old, AMH 1). We ended up doing 4 cycles because we had to freeze-all the one due to Covid and I wanted to give it 3 complete attempts so I would never have regrets. 2 of the cycles were really good, 2 not so much (again, you can see in my signature). Quite honestly, I would not have tried after 38 as the success rates go down per egg harvested to rates that I don't feel make it worth it with low AMH (as we only get so few eggs to start off with).
    I found the following 3 documents shared on the Lister homepage extremely helpful in showing me the real chance of success by age:

    https://ivf.devbrandcast.com/wp-content/uploads/2019/08/p422-what-is-ovarian-reserve-and-why-is-it-important.pdf
    https://ivf.devbrandcast.com/wp-content/uploads/2019/08/lister-fertility-clinic-ovarian-reserve-assessment.pdf
    https://ivf.devbrandcast.com/wp-content/uploads/2019/08/p420-low-reserve-or-poor-response-what-can-we-do.pdf

    If you have a cycle with less than 2 follicles (seems likely for you unfortunately) at 41, your chance of success is 5.7% at the Lister with one cycle. It really is up to you to decide if that's worth it for you. And I really would doubt any other clinic would offer you a better chance with own eggs.

    I think it's fantastic you are already considering donor eggs and in your position, I would definitely take that route. I value my life, my relationship and my happiness very much, I'm very lucky and have so many good things in my life, I did not want to waste so many years going through fertility treatments. Let's be honest, it isn't fun. Everyone on these forums that does DE writes again and again that their only regret is they should have moved on to DE sooner. It is, of course, a very personal choice though. But, if you can get your head around it, then why put yourself through all the misery, cost, stress and disappointment chasing that genetic connection.

    For DE, I can't comment too much because I never got there but I suppose a big deciding factor would be if you want the donor to be anonymous or not. That will cut down your choices either way, but there are many brilliant clinics out there, ready to offer you high success rates, so that you can move on to living a happy family life. The timing isn't so bad for you either, spend the next few months doing your research and figuring out what you want and where to go and setting it all up and by then the borders will almost definitely be open and Covid slowly fading into a bad memory.

    Good luck with whatever decisions you and your partner make.

    Offline Pritamin

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #244 on: 30/01/21, 15:48 »
    Saltysea - thank you for taking time to write such a long response. Youíre not upsetting me, itís always good to see other point of views from somebody whoís not emotionally involved. Youíve had your own journey so you have a lot of knowledge but can also see my situation from an unbiased point of view in terms of my emotions.
    I can see from your signature that you had a few to freeze from your first round but always went for a fresh cycle. What was the reason for that?
    I keep everything crossed for you so you can finally hold your little miracle in your arms in the summer xxx

    I think Iíll have to do a lot of reading (which I hate doing on the phone) and join a few DE threads (if anyone knows any thatís still current please let me know) just to see if thatís really what I want to do.

    for now I think Iíll take one step at a time (which has never been my strong point). Wait for the FSH on Monday.
    Based on that:
    a) bin this cycle (which is the likely option)
    b) carry on and have another scan on Wednesday and see what happens.

    If itís a) then wait for next period and go in for another baseline to see if things have improved.
    Though Iím worried if I donít take oestrogen then Iíll have a cyst and if I take oestrogen to prevent cysts then Iíll have zero follicles on baseline again.

    Sorry girls, I donít want to bore you with my thinking out loud. Xx

    Offline Sunshine122

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #245 on: 30/01/21, 17:02 »
    Pritamin, which clinic are you with now? I had my daughter with Create, they arenít perfect but overall I would recommend them. My daughter is 17 months now and if I did do anymore fresh cycles (which I wonít be doing) I would use them again. I would love a sibling for my daughter and its getting harder not to focus on it esp with too much thinking time on my hands during lockdown, but I know I canít get consumed by infertility/IVF again so we ttc casually (and probably pointlessly) each month.
    Iíve started taking 25mg DHEA, I found it in the cupboard as I never ended up taking it before in fear it would mess up an IVF cycle for us but now iím hoping it may just give things a boost, I actually feel a bit better in myself and none of the horrible side effects so fingers crossed x

    Offline Pritamin

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #246 on: 30/01/21, 17:20 »
    Sunshine - Iím with Croydon university hospital.
    They did my NHS funded cycle so we stayed with them as private patients. They use London Womenís clinic embryology team on Harley street for collections and transfers.

    Iím taking 600mg Ubiquinol (CoQ10) on my consultantís recommendation to improve egg quality. She said thereís some evidence that it does actually help a bit.

    Having thought about it I donít think I want to change clinics at this point if we stick to IVF because time is not on our side and starting with a new clinic would take too much time that I donít have :(

    Offline Sunshine122

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #247 on: 30/01/21, 17:32 »
    My first 3 cycles were with London Womens clinic. You just have to go with wherever you feel comfortable. Wishing you lots of luck xx

    Offline Saltysea

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #248 on: 30/01/21, 18:18 »
    Thank you for understanding so well - it's truly just my answer to your question of 'what would I do in your situation'. And also just a bit of support that there are plenty of people out there (including me) that don't think the egg donation route is such a 'last resort only' option. I also remember you from the chats from some cycles back where we cycled at a similar time. In fact, you were actually a bit of an 'inspiration' for me as I felt from your history (age and AMH and lack of other issues) our situations were very similar and because it worked out for you, it made me see it through when I was getting so few eggs myself  :).

    The reason I did all fresh cycles is that I decided I would 'bite the bullet' for 3 cycles and my chances are never going to be better for a fresh cycle than right now asap - since age is a massive factor in this and even more so for us with low AMH. We also knew we would want 2 children ideally so any extras can be used up trying for that later. Also, I like to get things over with, and now I'm so glad I did because I will never 'have' to do another fresh cycle again (even if this one hadn't worked out as well as it has so far). The Lister also said that there was a slight edge to the success of a fresh cycle. Although I think that belief is starting to be questioned somewhat, so I really would never regret freezing if there is a reason to not transfer (as I did when Covid first broke out in March last year).

    Just since you mentioned the donor egg research, I honestly would have been happy to go with it from the start and skip all the drama but it was important to my husband to at least try and I also agreed that with the Lister our chances of success looked 'alright', well good enough to at least give it a few tries with own eggs. I knew I would want to have information on the donor (including photos) and ideally also make it possible for the child to contact them when they are older. So, for me, it would have been South Africa or the USA. I found it psychologically, very reassuring to see some of the profiles of available donors on some of the websites whenever I felt negative during the treatment as there were so many lovely girls that I felt had every bit as good genetics to pass on as me. Being okay with Plan B made Plan A far less stressful for me and I always felt our chances of success with Plan B would be good. Hope that makes sense. In particular, I felt 'Global Egg Donors' had a great website for South Africa and well, the USA had many great websites. The difference there is that the USA allows contact details for the child to be recorded but is a lot more expensive.
    If you don't feel the need to see photos and have detailed information and pick your own donor then there are many super affordable, fantastic clinics in Europe - Spain, Czech and Greece. Portugal and the UK, I believe are the only countries in Europe that allow contact information (but only afterwards for the child so you still don't have a say in who your donor is). Ukraine and Russia seemed to offer everything but quite honestly, always left me with a dodgy feeling, I couldn't have gone with them. 

    One step at a time was my motto through all of this as well and without it, I would not have survived, so I think you have the perfect approach! You will definitely find the right solution for you and your family.


    Offline Pritamin

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    Low AMH/High FSH Cycle Buddies - Part 8
    « Reply #249 on: 30/01/21, 19:26 »
    Salty - Again, thank you so much for the long reply.
    I think what you did with banking cycles was a very good idea. In a hindsight I should have done that too, though after ARGC we went to nhs straight away where this wasnít an option and quite frankly after the second FET which resulted in our daughter we didnít really think about it.
    You have a wealth of knowledge on DE already so I think Iíll send you a PM so I donít actually hijack this thread :) 🙈

    Xx