[babyphatt]

Hi Ladies,

I will appreciate if those who have had success conceiving with adenomyosis (fundus) share their experience(s) of what they think contributed to their success stories
with me please. 

I have had 4 failed OE cycle, and had to take a break for couple of years as my husband suffered massive cardiac arrest in 2017 and has remained in a vegetative state up until now. However as age is no longer on my side, I have decided to move things forward by settling for a donor sperm. Whilst this is the case, I don't think i will be able to deal with  any BFN heartache considering all that I have going on for me at the moment, hence I am keen to know what and how to increase/boost my chances to conceive . 

I have seen people talk about debunking and which really and truly I  wouldn't mind considering as an option to start with, provided there's light at the end of the tunnel. I have down regulated in the past which led to a CP afterwards and yes I could also consider this as an option.

 

[Miss Sunshine22]

Hi Babyphatt

So sorry to hear of your husband having a cardiac arrest and being in a vegetative state. That must be so hard for you 

For me, downreg medication (decapeptyl) for 4 months shrank my adeno - which was also on the fundus - and my son was born as a result. It's not a pleasant drug and I still shudder when I think of the side-effects, but it was definitely worth it.  There are a few research papers to support this as an option for people with adeno and with recurrent implantation failure.

Best of luck 

 

[babyphatt]

Hi Sunshine22,

Thanks a lot for your response as well as your kind words.

I have once down regulated so I can relate with your experience. Can I ask if the (decapeptyl) caused you any weight changes?. I'm petrified not to put any weight on. I can deal with the headaches and hot flushes though.

 

[Miss Sunshine22]

Hi Babyphatt

No, it didn't cause any weight changes. Splitting migraines, brain fog and a bit of low mood when the estrogen finally dried up. Plus insomnia and hot flashes ugh. They did ease up (apart from insomnia and flashes) after a few weeks though. The weird thing as well was, even a sniff of alcohol would leave me clutching my head in agony the next day  so I had to completely give it up for the duration. Not a bad thing in the scheme of things, but still ...

 

[babyphatt]

Hi Sunshine22,

Thanks for this info, atteast am a bit rest assured it may or may not cause weight changes as I've always thought that was a definite.

I remember I did have insomnia, body pains and headaches when with Lupron which resulted in a chemical anyways,
Yes, so I'm guessing that helped to an extent.

I think I will be asking for a longer protocol this time to increase my chances.

Can I ask which hospital/specialist you went with? I'm with ARGC and they seem not to believe so much with down regulating when I suggested the option to them.

 

[Miss Sunshine22]

Hi Babyphatt

We were with Reproductive Health Group in the North West at the time. I wonder why your clinic is against prolonged downreg? Will it be a fresh cycle you do? Prolonged downreg can make it harder to switch the ovaries back on - that's why I never did it for fresh cycle, only FET.

 

[babyphatt]

Hi Miss Sunshiine22,

Apologies for the late response. Just been all over the place. I plan to do an FET, I've just not had the nerves to start tbh as I'm scared of the emotions that comes with and each time I want to encourage myself it will work this time, I just come back to this chat thread between you and I for assurance. I'm going to insist on Dr at least for 6months, owning to the fact it worked for you. Can I ask how big your adenomyosis is? How enlarged is your womb? Mine is at my fundus, not sure if it diffused.

 

[Miss Sunshine22]

Hi Babyphatt

For 1st bfp, I did downreg for 4 months - no change to adeno after 2 months of daily buserelin. Switched to 2 months decapeptyl monthly injection and was told adeno had shrunk by about 30 percent after 2 months. For this transfer, I was told it was mainly on the fundus, but not how large it was.

I'm currently pregnant with no2. For this transfer, I did 2 months downreg with decapeptyl and some HRT addback to reduce side effects (although still felt pretty rubbish even with this). Again, not sure how much adeno I had, but was told on several scans I had a bulky uterus and fundal adeno (which suggests more diffuse as well). After 2 months decapeptyl, scan showed adeno had shrunk significantly and consultant was happy to transfer.

Might be worth asking for scans every 2 months to check on progress? You may not need 6 months ...?

 

[babyphatt]

Thanks, for your response Miss Sunshine22 and congrsts on your BFP, Great News!!!!. Did you use the same clinic as your first cycle? What HRT addback did you use?

 

[Miss Sunshine22]

Hi Babyphatt

Yes, we used the same clinic. The HRT was Evorel Conti patches - very low estrogen dose. They stopped the hot flashes and insomnia, but I still got v bad migraine the first couple of weeks of downreg. Plus, I bled for most of the two months while on them, and had v bad period pains for a few days on them. However, this didn't effect the success of reducing the adeno, and ultimately the transfer.

Fingers crossed your clinic agrees with your downreg plan. Let me know how you get on?

 

[babyphatt]

Hi Babyphatt

Yes, we used the same clinic. The HRT was Evorel Conti patches - very low estrogen dose. They stopped the hot flashes and insomnia, but I still got v bad migraine the first couple of weeks of downreg. Plus, I bled for most of the two months while on them, and had v bad period pains for a few days on them. However, this didn't effect the success of reducing the adeno, and ultimately the transfer.

Fingers crossed your clinic agrees with your downreg plan. Let me know how you get on?

Hi Babyphatt

Yes, we used the same clinic. The HRT was Evorel Conti patches - very low estrogen dose. They stopped the hot flashes and insomnia, but I still got v bad migraine the first couple of weeks of downreg. Plus, I bled for most of the two months while on them, and had v bad period pains for a few days on them. However, this didn't effect the success of reducing the adeno, and ultimately the transfer.

Fingers crossed your clinic agrees with your downreg plan. Let me know how you get on?
Thanks Miss Sunshine22, you've been very helpful by answering all my questions which I appreciate.
Honestlt, I am tempted to switch clinics to yours but not sure on how accessible it will be for me as I live in London.
Do you mind me asking how much the cycle cost in total?

 

[Miss Sunshine22]

Hi Babyphatt

I can't remember how much exactly as we paid in dribs and drabs, and it was a FET. They weren't the cheapest - but I think their website lists all their prices. Extras included injectable progesterone Lubion (which was eye wateringly expensive, but I needed that plus cyclogest to bring levels up to normal. Got it cheaper at Asda pharmacy), clexane due to DVT risk, COVID test, transfer under sedation to reduce uterine contraction, tests for STIs required by HFEA. It all added up to easily £2,000 I would say.

 

[babyphatt]

Hi Babyphatt

I can't remember how much exactly as we paid in dribs and drabs, and it was a FET. They weren't the cheapest - but I think their website lists all their prices. Extras included injectable progesterone Lubion (which was eye wateringly expensive, but I needed that plus cyclogest to bring levels up to normal. Got it cheaper at Asda pharmacy), clexane due to DVT risk, COVID test, transfer under sedation to reduce uterine contraction, tests for STIs required by HFEA. It all added up to easily £2,000 I would say.

Hi Babyphatt

I can't remember how much exactly as we paid in dribs and drabs, and it was a FET. They weren't the cheapest - but I think their website lists all their prices. Extras included injectable progesterone Lubion (which was eye wateringly expensive, but I needed that plus cyclogest to bring levels up to normal. Got it cheaper at Asda pharmacy), clexane due to DVT risk, COVID test, transfer under sedation to reduce uterine contraction, tests for STIs required by HFEA. It all added up to easily £2,000 I would say.

Thanks Miss Sunshine22

 

[babyphatt]

Thanks Miss Sunshine22

Hi Miss Sunshiine22,

How is it going, have you had your baby yet? Just thought I Check in? My prayers are with you.
On another note, can I please ask who the consultant you saw in RHG was please?

 

[Miss Sunshine22]

Hi Babyphatt

Thanks for checking in. Yes, she arrived safe and sound last month - a bit earlier than expected at 34+6 - we had been aiming for 37 weeks, but complications meant the c section was moved up. It all went well though, and she is continuing to feed and grow!

The original consultant I saw is no longer at RHG. For this pregnancy, I saw the two main ones on the website - they were both fine and happy to stick to the original transfer protocol of the first FET. I don't think either works full time, so they split the week between them (that's what I was told anyway)

 

[babyphatt]

Awww, congrats, happy she arrived safely..

No p, would you know what their names are please, if you don't mind sharing with me?

 

[Miss Sunshine22]

Hi Babyphatt

Tried to send you a pm but can't work out how to send??

Regards

Sunshine

 

[babyphatt]

Hi Miss Sunshine22,

You can send to my email [email protected].