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Discussion Starter · #1 ·
Hi Ladies, I hope you're all doing well, this is my first post. Today I found out my second round donor egg IVF failed, suspected chemical as I had a positive a few days ago, now day 15 post transfer 4 negatives, I'm gutted to say the least. I'm 43, one DS natural age 4. In the last 3 years I've had 2 failed donor egg cycles, 2 chemicals and one miscarriage 8 weeks (hemorrhage)

I was sure this cycle would work as we threw everything at it: Fresh Egg donor aged 20, PGS, 5 day blast grade B, long 6 week protocol at CRGH, lining approx. 8mm, hysteroscopy clear, water test good, endo scratch, twice weekly acupuncture, DH morphology good, meds: Viagra, Lenotogest, Evorel, Vitaimin E, Inhixa, Crinone, Utrogestan, Progynova, Folic Acid, Multivtamin, Vit D.

First round at LWC failed no chemical, frozen egg transfer.

I've been researching online for possible reasons, immune killer cells? Also, using steroids and intralipids next time? Any advice / possible reason for failure and or how to have success would be so really good right now. Thx ladies xx
 

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Hmmm, the fact that you conceived and carried naturally at 39 is telling me that nothing is wrong with you. May I ask if it was the same donor in both cases? Also was the spem from the same partner that you conceived your son (sincere apologies, i don’t know you history if you are married, using a donor etc).
 

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Hi, I am sorry you are going through this. I have same questions as a poster above, and if donor's eggs have been PGS NGS/PGD tested.
 

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Just wanted to send you some love 💕💕💕💕
 
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Hi,

Here are some things to consider - Your thyroid TSH must be between 1 and 2. I would advise you get an up to date test and ask the doctor for your actual numbers as many GPs sign you off above this number which can be a cause of implantation failure and miscarriage.

I would look again at sperm as DNA fragmentation increases with age and there may be hidden issues.

Other tests would be clotting panel e.g. factor V leiden, antiphospholipid syndrom, prothrombin gene mutation, MTHFR. etc. Autoimmune would include RA and anti nuclear antibodies. A GP could run a panel like this.

Immune testing could be done with a specialist like Dr Gorgy for example. Other causes of failure could be infection e.g. chlamydia, Strep B, mycoplasma, ureaplasma etc.

I had six miscarriages, 3 own egg and 3 double donation. My successful cycle was with clexane, steroids, IVIg, injectible progesterone and high dose folic acid and vitamin B12 and 6.

Lots of luck,

ALS
 

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Discussion Starter · #6 ·
Hmmm, the fact that you conceived and carried naturally at 39 is telling me that nothing is wrong with you. May I ask if it was the same donor in both cases? Also was the spem from the same partner that you conceived your son (sincere apologies, i don’t know you history if you are married, using a donor etc).
Thanks so much for replying - I had AMH 0.1 and miscarriage history so opted for DE... different donor each time. First round frozen eggs, second round fresh eggs. Yes sperm from DH, we are doing sperm fragmentation this round. Thanks again for your help :)
 

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Discussion Starter · #9 ·
Hi,

Here are some things to consider - Your thyroid TSH must be between 1 and 2. I would advise you get an up to date test and ask the doctor for your actual numbers as many GPs sign you off above this number which can be a cause of implantation failure and miscarriage.

I would look again at sperm as DNA fragmentation increases with age and there may be hidden issues.

Other tests would be clotting panel e.g. factor V leiden, antiphospholipid syndrom, prothrombin gene mutation, MTHFR. etc. Autoimmune would include RA and anti nuclear antibodies. A GP could run a panel like this.

Immune testing could be done with a specialist like Dr Gorgy for example. Other causes of failure could be infection e.g. chlamydia, Strep B, mycoplasma, ureaplasma etc.

I had six miscarriages, 3 own egg and 3 double donation. My successful cycle was with clexane, steroids, IVIg, injectible progesterone and high dose folic acid and vitamin B12 and 6.

Lots of luck,

ALS
Thanks so much ALS! This info is super helpful. I'm sorry to hear about your losses but glad your got success. I spoke to the doctor today and we will run sperm fragmentation and immune biopsy etc before the next round. I will also ask about the points above, thanks so so much super helpful. I had all meds you listed plus Viagra lol, but not the steroids yet... How is your LO?
 

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Thanks so much ALS! This info is super helpful. I'm sorry to hear about your losses but glad your got success. I spoke to the doctor today and we will run sperm fragmentation and immune biopsy etc before the next round. I will also ask about the points above, thanks so so much super helpful. I had all meds you listed plus Viagra lol, but not the steroids yet... How is your LO?
So it has taken me so long to reply - haven't got the hang of the website format! Just to say that my twins are now 15 and very well thank you! The journey was a long time ago, but I just can't stand to see anyone else struggle like I did. I do hope that you can move on to success very soon! xx
 

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So it has taken me so long to reply - haven't got the hang of the website format! Just to say that my twins are now 15 and very well thank you! The journey was a long time ago, but I just can't stand to see anyone else struggle like I did. I do hope that you can move on to success very soon! xx
congrats on your twins
 

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Hi. I'm really sorry to hear about your failed cycle. I hope you are ok and have a plan to move forwards. I have had treatment at CRGH (unfortunately unsuccessful but OE). I certainly would recommend them, and wonder if they have considered putting you on steroids (Prednisolone) empirically and also clexane. I have tried viagra to help with endometrial lining and have to say it made no difference. Also had intralipids - only one cycle but got a BFN. My successful cycle was abroad at Dogus (north cyprus) but appreciate not so easy right now with travel restrictions. Re: thyroid - have you had TFTs and thyroid antibodies checked? Fertility guidelines generally recommend TSH is below 2.5. Dr Seshadri is very knowledgeable about all these things at CRGH - it might be worth getting her opinion? Good luck x
 

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Hi. I'm really sorry to hear about your failed cycle. I hope you are ok and have a plan to move forwards. I have had treatment at CRGH (unfortunately unsuccessful but OE). I certainly would recommend them, and wonder if they have considered putting you on steroids (Prednisolone) empirically and also clexane. I have tried viagra to help with endometrial lining and have to say it made no difference. Also had intralipids - only one cycle but got a BFN. My successful cycle was abroad at Dogus (north cyprus) but appreciate not so easy right now with travel restrictions. Re: thyroid - have you had TFTs and thyroid antibodies checked? Fertility guidelines generally recommend TSH is below 2.5. Dr Seshadri is very knowledgeable about all these things at CRGH - it might be worth getting her opinion? Good luck x
hi how did you get to dogus, and how long did you have to stay in nc for
 

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Discussion Starter · #14 ·
So it has taken me so long to reply - haven't got the hang of the website format! Just to say that my twins are now 15 and very well thank you! The journey was a long time ago, but I just can't stand to see anyone else struggle like I did. I do hope that you can move on to success very soon! xx
Hi ALS, thanks again for your help and I hope you're doing well!

So currently preparing for ET number 3 with DE. My FSH was high so I'm on Femoston for 3 months and then the same protocol as before including IVIG and steroids due to immune killer results. We have 2 embryos both pgs tested so fingers crossed.

How did you find the IVIG was it ok and how many doses? We have been advised 3 doses of IVIG. And the steroid side effects?

Also, the high dose folic - what was the reason and dosage? I have the MTHMR (spelling) mutation and so I think I need to look at increasing folic acid also.. thanks again for your help x
 
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