I have finally got my test results back. What does an FSH Level of 13.7 and oestrogen of 134 mean? is there anything i can do to change these levels if the results are poor?
when i went to a bridge clinic seminar they showed how they could reject embryos which were chromosomally abnormal the good embryos are then implanted back in the womb. they were talking about using this process with IVFdaisyg said:Shad,
IVF does NOT choose the best embryos - it is onlyPGD (Preimplantation Genetic Diagnosis) that can do this.
Your FSH is highish and may be slightly falsefly suppressed as your E2 seems on the higher side. These are not unusual results for your age.
BUT, FSH can not give any indication of the quality of your eggs and at 45 your chances with ivf are very, very slim I am sorry to say. FSH levels may give an indication of how well you may respond to FSH stimulating drugs. Have you had an antral follicle count at all? This also provides useful info. However, you may obviously want to try a cycle for closure and I totally understand this.
The biggest advantage of ivf is that it produces as many eggs as possible (and hopefully embryos) which will increase chances hopefully. Studies at Cornell showed that women of 45 did best when they produced 5 or more oocytes. About 3% had a live birth and 85% miscarried, so that does indicate that is is much harder and more of a lottery getting a normal embryo - but not impossible of course.
I have replied in detail to you on this subject before but I think one has to try an ivf cycle for closure before moving on to DE or whatever you and DH choose as the best option for you.
In my previousl reply I also outlined that very, very few women have had a live birth via ivf with own eggs in the UK (top 2 US clinic's have better results but still only a handful of women have achieved this).
I think I also stressed that you and DH would be well advised to check out other issues as well to give you optimum chances for conception whether with own eggs or DE and these would include sperm dna fragmentation, karyotyping, thyroid, uterine checks for fibroids etc, bacterial checks and basic blood tests to eliminate basic clotting and ANAs etc. Your GP can do many of these.
Finally, the vast majority of women aged 45 who do conceive to so naturally - and this is still a small number. There is a very good website for women over 40 ttc which can give lots of info. you may be interested in.
Just to address the last part of your post. IVF will not choose chromosomally normal embryos as you describe. Only PGD can do this (and this is not guaranteed either). You cannot know whether the embryos are genetically normal just by looking sadly.
I have also noticed you do have fibroids - have you checked these out recently as I would strongly recommend you have an hysteroscopy and removal of any fibroids which may hamper conception and pregnancy. This will affect a DE pregnancy should you decide on this route.
Best of luck,
Hi Daisy I will discuss my options with Lister since i have decided to go theredaisyg said:Shad,
This process is called PGD (Preimplantation Genetic Diagnosis) as I described in my first post. This is the only way you can check which embryos are chromosomally normal before transfer. You have to do ivf to do this as you need to remove cells from the fertilised egg and sperm (embryo) in order to test this for abnormalities. These embryos are then replaced.
However, PGD has not been shown to increase live birth rate in over 40s but may reduce miscarriage rate. Be aware however, that it can only test for a limited number of chromosomes and cannot guarantee either a pregnancy or avoid a miscarriage.
You also need a good number of embryos to make the procedure worthwhile as there maybe false postives and neg. which will mean some potential normal embryos may be discarded. You would be hopefully left with embryos to transfer.
It is certainly something to consider, but is expensive. Have you talked to the Bridge about using PGD/PGS and what their success rates are with women of your age etc?
Best of luck,
Hi Daisydaisyg said:Shad,
Wish you the very best of luck - the Lister are a very good clinic and I got pregnant there with my own eggs at age 44 (but sadly miscarried).
Hi Daisydaisyg said:Hi Shad,
Stick with the Lister - they at least have had live births with older women than the LWC (who do not have good ivf rates for over 40 by the way...).
Even if you do decide to persue IUI I would still choose the Lister personally. If you can afford it then I am sure the Lister will let you cycle if only for some kind of closure which is important before moving on to DE or any other avenue you decide. The Lister also do PGS/PGD...
I agree that your top priority is to get rid of any fibroids and get some basic checks done which will help you whether you do own eggs or DE. e.g. fibroids, thryoid, insulin resistance, karyotyping, some basic clotting factors, etc.
It is good that you are getting going and starting with the fibroids sounds positive.
Wishing you lots of luck,