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Discussion Starter · #1 ·
Hope this is a good place to start posting information I've been collecting for couples who have also had what was a pretty massive shock for us at the time.

We've just bumbled through the last 2 years and 3 cycles of ICSI and are only now just about getting to grips with the diagnosis. Our journey has been a bit of a minefield, so few specialists in male infertility and so many conflicting studies and opinions...

And, of course, trying to pin down a clinic on their success rates for azoospermic patients, well, ;D that's a good one eh? Would love to hear from anyone who DOES have concrete stats on that!

Here's a nice introduction from the Sher Institute based in the States
MALE FACTOR INFERTILITY: A RATIONAL BASIS FOR TREATMENT
http://www.haveababy.com/infert/maleinfert.asp?site=

It covers hormonal therapy, risks of ICSI, diagnosing and treating the causes of azoospermia and Sperm DNA Integrity (SDI) testing.

P.S. This started from a discussion on the Male Factor thread started by a girl called Fin on FF. The thread has got so big a lot of the original links and info is WAY.... down the board now!

So I'm going to try really hard to keeping adding to this thread as I've got quite a lot bookmarked.

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Good Morning Claudine,

You really are a star and never cease to amaze me with your vast of knowledge.  ^bow^

You are right there have been so many things discussed on our other thread that I have also lost track and have started to go back over previous posts to print off anything I think may be useful for my IF file.  If I come across anything that you could add on here I will let you know.

Thanks again babe, you really are a star.  ^afro^

Lol

Fin
 

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Discussion Starter · #3 ·
Hey Fin,

Thanks for the compliment, and I'm glad you like the idea. I wonder if we can get it pinned to the notice board if it's info?

I'm trying to do one site a day, starting with general info on causes of male infertility and this is one of my favorites as it's really clear and really concise, explains how it all works (including diagrams!) from a clinic in Australia

http://www.andrologyaustralia.org/infertility/causes.htm

and if anyone follows Neighbours, I noticed Max picking up a leaflet from this clinic that had been kindly left "lying around" by his DW. Nice bit of promotion there for them!

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Discussion Starter · #4 ·
Have just realised that there's an additional section which is an issue rarely addressed elsewhere

Emotional Impact of Male Infertility on Men

This really is an excellent site for couples who've just been told the sperm count is zero (or close to it) and want to know where to go from here.

It covers: physical examination, hormonal analysis, genetic investigations, testicular biopsy, urine analysis - and the implications of the results thereof.
 

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Hello

Thank you for taking the trouble to suggest useful links.  I had a look in the Australian one and found some info that relates directly to out situation. I hadn't realised that hormonal problems are so rare in male infertility until i joined FF but it explains why there are always a gaggle of student docs present at any of our consultations.  The site suggested that treatment could take a couple of years before decent numbers of sperm are produced and I think I'm glad that i didn't know that when we started 18 months ago.  I'm encouraged by how positive the site was about the success of treatment.  We have another appointment at the end of the month so keeping fingers and toes crossed for a good result.  Thanks again.

Mrs C
 

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Discussion Starter · #6 ·
Dear Mrs. C,

I'm so glad to have helped in some small way.  I am keeping everything crossed for you for the end of the month and will look forward to hearing your (good!) news.  I must admit I don't know too much myself about hormonal treatment, am really hoping it's successful for you.

All best wishes to you and your DH
 

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Discussion Starter · #7 ·
Another centre for excellence in male infertility is Cornells in New York. They have quite a comprehensive website but it's not as easy to follow as the above ones.

http://www.maleinfertility.org/

However, they cover:
Understanding Male Infertility
The Fertility Evaluation
Surgical Sperm Retrieval: Which Method to Use?
Management of Men with Non-obstructive Azoospermia
Non-obstructive Azoospermia and TESE
Microsurgical Retrieval of Epididymal Sperm (usually applicable for Obstructive Azoospermia)
Lifestyle and Dietary Recommendations for the Infertile Male
Varicocele & Treatments

There's even a video clip of microsurgery, I don't think I'll be watching... ^zombie^

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Hi Claudine,

And apart from having a great website they are also very informative when you contact them.

Thumbs up from me.  ^afro^

Lol

Fin
 

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Hi there Claudine

There are a couple of sites that I have found which I will send to you so you can decide whether to add them to your list or not.
Thanks so much for doing this.
Good luck at ARGC
Much love Selina x
 

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Discussion Starter · #10 ·
Hi Selina,

Thanks for your links: I'll put up my favorite one which is the one with abstracts of studies on male infertility. There are quite a few listed and a few findings contradict each other. Interesting to note that this study found that incubation of testicular sperm improved pg rates.

http://www.fertilitydirectory.org/news_updates_mi_icsi01.html

[Modified by SueMJ - Due to Copyright on these sites]

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Discussion Starter · #11 ·
Here's a slightly more random article but highly relevant to those of us who are pinning our hopes on very few sperm. It may not be helpful to us right now but I'm glad to see that at least somebody's working on improving our odds!

Experimental Procedure Uses Algae For Freezing And Storing Very Small Numbers Of Sperm

Even some patients who do not have sperm in their ejaculate can father children by means of ICSI- intracytoplasmic sperm injection. But their treatment is complicated by the need to extract sperm surgically from the epididymus or from tissue removed from the testis. In these cases, technicians try to retrieve the greatest number of sperm possible so that some extra sperm can be preserved for future ICSI attempts, thus saving patients from having to go through additional tissue-damaging sperm extractions or surgeries. In order to aid recovery of these small numbers of sperm after freezing and thawing, methods are being developed to keep the sperm confined in a microscopic container during the cryopreservation process.

Researchers in Austria have adapted a procedure originally developed to freeze small numbers of sperm using zona pellucidae (the outer membranes of egg cells) as containers. Using micromanipulation techniques, they injected sperm instead into the centers of tiny spherical colonies of Volvox globator, an algae.

Fifteen patients with severe male factor infertility were recruited from two Austrian IVF programs. For each patient, eight motile, morphologically intact sperm cells were injected into each of three Volvox spheres, which were then frozen according to a standard sperm cryopreservation protocol and stored in liquid nitrogen for three months. Upon thawing, all 45 Volvox spheres were intact; all 360 sperm were recovered; and at least five sperm from each Volvox sphere were motile.

The researchers plan further studies involving the fertilization of rabbit eggs with rabbit sperm that have been stored frozen in Volvox. Resulting embryos will be tested to see if genetic material from the algae is transferred to the egg as a result of the manipulation.

"Volvox could have some advantages over zonas for sperm storage. It is inexpensive, readily available and would not induce an acrosome reaction like the zona. If, after more extensive testing with animals, the technique proves safe and is approved by the FDA, it could be an excellent tool for preserving small quantities of sperm," remarked Owen Davis, MD, President of SART, the Society for Assisted Reproductive Technology.

(Just et al, Novel method for the cryopreservation of testicular sperm and ejaculated sperm from patients with severe oligospermia: a pilot study, Fertility and Sterility, Vol.82, No.2, August 2004.)

ASRM BULLETIN
Volume 6, Number 36
August 13, 2004
HIGHLIGHTS FROM FERTILITY AND STERILITY
Volume 82, Number 2, August 2004

http://www.asrm.org/Washington/Bulletins/vol6no36.html#algaesperm

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Claudine you are a Superstar!!! ^dancing spot^ ^rainbow^ ^sperm^

This is a fab thread to start.

Being a big wimp I flick Neighbours over when the IVF story comes on!  Its my escapism, i'm gutted its been hijacked by IF but I guess it raises awareness (except Steph and MAx seem so damn happy all the time!) 

.........anyhow I digress!!!!

If i find any informative sites I'll stick em on here. I too feel a bit lost on our other thread we've grown so big and so varied!

p.s Hi Fin  :)

 

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Hi - hope I'm not butting in irrelevantly here. Just wanted to let you know that my DH has azoospermia due to a childhood accident. He had SSR (pesa/tesa) at Midland Fertility Services in Aldridge (Gillian Lockwood). We got enough swimmers for 5 ICSI attempts and were successful on our 5th attempt. Hope this can give inspiration to anyone in a similar  situation.

Love from Carole
xxxxxxxxxxxxxxx
 

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Thanks Carole, its always nice to hear of success stories.  And of course...congratulations on your bundle of joy!

 

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Hi Claudine,

Just stumbled upon this board which I found helpful. There are lots of answers on there relating to Azoospermia along with a section where you can actually leave questions for the doctors:

http://www.maleinfertilityspecialist.com

Lol

Fin

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Discussion Starter · #16 ·
Hi Fin,

I'm going to think of a good question... ::) but want to make sure it's the right one. Don't want to waste my wishes!

I am thinking of getting one of the recommended books, two of the three must be medical textbooks as cost $200+ each, but the third one looks like a good read...

Here's the Amazon rundown, costs $16.95 in the States, I'll have to see whether I can get in over here

Overcoming Male Infertility: Understanding Its Causes and Treatments
by Leslie R. Schover, Anthony J. Thomas
"Like a ship that hits a massive iceberg hiding beneath calm waters, it is usually a shock for a man to discover that he has a fertility problem..."

Editorial Reviews

From Library Journal
Although it is not a commonly recognized fact, the male is the problem in about half of the 2.5 million couples struggling with infertility. Clinical psychologist Schover and Thomas, a urologist in the Cleveland Clinic's infertility program, draw on their expertise to provide information that lay readers need to understand the causes of male fertility problems. They discuss how to find competent doctors and demystify the available treatment options for infertile couples. They also clearly explain reproductive anatomy and physiology, diagnostic procedures, causative factors, and therapeutic options, as well as the psychological and emotional aspects of male infertility. Recommended for all healthcare collections.AJames Swanton, Harlem Hosp. Lib., New York
Copyright 1999 Reed Business Information, Inc.

Product Description:
Hope and strategies for couples dealing with male infertility If you or your partner is suffering from male infertility, you're not alone. Millions of couples are struggling with this problem. About 400f these couples have exclusively male infertility problems, while another 20% have both male and female infertility problems. Now, two leading experts, a urologist specializing in male infertility and a psychologist, team up to write the most complete guide available on male infertility. From the latest, state-of-the-art treatments to advice on how to handle the emotional aspects of male infertility, you'll find out where to get the help you need. Overcoming Male Infertility also covers the psychological issues that are unique to men, and gives advice to women on helping their man through the trauma of infertility treatment-including how to get him to see a doctor in the first place.

You can see some of the introductory places on the US Amazon site

http://www.amazon.com/gp/reader/0471244716/ref=sib_fs_top/104-0872799-3764745?%5Fencoding=UTF8&p=S00K&checkSum=dqDA8gt0r992E%2FspPhfSO6bpUoac0IU1GWlVw7zHOnI%3D#reader-page

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Discussion Starter · #17 ·
P.S. THANK YOU CAROLE!

We need to know of other azoospermia BFPs - the hope of success is all that keeps us going...
 

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Hi Claudine

Thanks for the suggestion of the book - will look into getting it Debs x
 

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Hi Claudine,

I don't seem to stumble upon many success stories from Azoospermia here in the UK but there are loads of them on a couple of American boards I pop in on.

I'll jot down some of the addresses for you tomorrow.

Lol

Fin
 

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Hi - I'm new here.  My husband has obstuctive azoospermia.  It is a condition I guess he was born with, we're not sure.  I live in the states and a urologist told me that our best hope was IVF with ICSI with sperm asperation.  We did the procedure in June 02 and it was successful.  I have a healthy baby boy who just turned 2.  We froze 2 embryos and went back for them last July and I had a biochemical pregnancy.  We just finished going through our 2nd cycle and it turned out to be negative.  I was wondering if anyone has found other viable options other than IVF for azoospermia?  IVF is sooo expensive.  The thought of doing it again doesn't appeal to me at all right now.  Any suggestions?
 
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