Just been reading this thread and thought I would add our story as we found it useful to read about others experiences when going through IVF.
We had being ttc for four years. My partner had 4 positives, but these ended in 1st trimester miscarriages. As she was (almost) 45, we decided to try a cycle of IVF so that if we remained childless we would feel at least we'd explored every avenue. We settled on ARGC for the usual reasons. Initial tests revealled high NK cells which could be the reason for the m/c's, so we decided we'd go for IVIg (but were unconvinced by Humira). FSH was pretty good at 5.5. We started the stim's, and my partner responded well (too well, she only took injections for 2 days and with hindsight had ohss) Anyway, at EC we had 21 eggs (wahey!).
We decided on ICSI+PGD. (I don't know why we were given ICSI rather than IVF as no male factors). We decided on one cycle with PGD (rather than two cycles without) as it appeared to be statistically a better option at this age, particularly has we had a lot of eggs, and would also avoid the possibility of a termination if we transferred an embryro with Downs etc.
Anyway, 16 eggs fertilised (wahey! again). Many of the embryo's looked pretty good and started compacting etc. but the PGD revealled that every single embryo was abnormal (I think they repeated the PGD on some embryos to be certain). Apparently, the best looking one turned out to have Downs. So no transfer. As you can imagine - somewhat of a shock to go from wondering how many embryo's we may have to freeze to not even getting to ET in the space of a few days!
However, we had always tried to take a realistic outlook on the whole thing and in some ways this was the second best result as it was very conclusive and gave us a sense of closure. (Maybe if we'd not had the PGD, it would have ended in a m/c and we would have tried again with Humira etc.).
We had a follow-up consultation with Mr. T at ARGC and even he - who must have seen it all - seemed surprised by both the number of eggs and the number that were abnormal. He agreed that continuing treatment didn't appear worthwhile. So after having put of lives on hold for the past few years, we started planning for a child-free future.
Ironic postscript: we now know that during the follow-up consultation, my partner was 2 weeks pregnant (the first natural cycle after the IVF and we weren't ttc). Obviously, with the PGD results we were very cautious, had nuchal-fold, CVS, ultrasound tests as soon as possible etc. but we're now at 24 weeks and everything still looks totally normal - expecting a daughter at the end of January! It's a cliche, but the last year has definitely been an emotional rollercoaster - the very best of luck to everybody riding it!