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Discussion Starter · #1 ·
We had our consultation with Care Manchester today.

Most things came back normal or clear. But:

we have Heterozygous Mutated PAI-1 4G/5G
Which we've been told is something to do with clotting issues, but I need to look into this. I need to take Metformin for this starting now.
Anyone have any experience of this?

My NK Cells were slightly elevated at 50:1 at 18.8 This did come down to 8 at 12.5 and 12.4 at 6.25
For this he said I need to have intralipid infusions which are worrying me somewhat. My levels don't seem to be too high though do they? He also said I would be taking steroids when treatment started.

I guess I'm just looking for a bit of feedback really. Obviously, there is nothing major and for that I'm really grateful.

The thing that got me more than anything else is that he said I would need to go on the long protocol for our frozen embryo transfer. It was only after I left that this concerned me. I've never downregged for frozen transfers before and really really don't to have to go through that again, I'd much rather do the regular programme. Is this standard practice when having immunology treatments alongside?

Thankyou
 

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no, the protocol you use for FET doesn't normally depend on your immune issues - but presumably your consultant has another reason why he wants to carefully control your hormone levels?

for the PA1 - look under T for thrombophilia in the FAQ

and for the NKa look under N (and I for intralipids)
 

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Discussion Starter · #3 ·
Thanks Agate, good to know the protocol is not dependant on the immunology; I've sent them an email today requesting an explanation so we'll see what they say.

I've done the reading on the Intralipids but thanks for the link to the PA1, I couldn't find it anywhere  :)
 

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Hi nutmeg, we are going to see Mr Patel at Care Manchester on Tuesday. I've just had some of my results back so have sent them all up to them ready. We live in the Channel Islands so are hoping he'll have some answers for us having had a mc and 3 failed IVF attempts at a different clinic.

Good luck on your journey.
 

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Discussion Starter · #5 ·
Good luck Mrs G, quite a journey for you then? What made you decide on Mcr Care?
 

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We have direct flights to Manchester and wanted somewhere that specialised in the repeated failures. Having looked on websites etc the reports back for them were good so we decided to give it a go.
 

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Discussion Starter · #7 ·
Well, good luck to you, let me know how you get on. Are you hoping for a new cycle in the new year?
 

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Hi nutmeg, did you ever get an explanation re the long protcol?

We saw Mr P yesterdday and have left somewhat confused (see my post). But he said to us they never did long protocol, only short as they don't believe in suppressing the bodies natural instincts completely......

I must say I'm not entirely sure I feel happy with him.

x
 

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Discussion Starter · #9 ·
Hmmm, well I've had no reply to my email about why we're being put on the long protocol, although I'm guessing they're pretty much on Christmas shutdown now. But to say they don't the long protocol just isn't right  :mad:  We got the paperwork through with the protocol and all directions on it which includes downregging for 21 days.
At least if he's not told you you've got to do that, then I shall get back in touch after the holidays and be pretty firm that we don't wish to follow the long protocol and try and not worry about it over Christmas.

Being totally honest, I'm not that keen on him either, I feel he doesn't give full explanations, doesn't listen to questions and talks to you like he's a school teacher (this is what my dh said).
Will go for a read of your post now.
 
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