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Discussion Starter · #1 ·
I'm wondering why nothing seems to work for me and thinking that maybe I have immune issues or something. 

I've had 2 DIUI's with a proven donor but both BFN's.

I had one OEIVF, got 8 eggs, 5 or 6 mature, 4 fertilised but only 2 were good enough to transfer.  Got a BFP but then at 7 weeks scan there was an empty sac.

I've now just had DFET at Reprofit with 2 top grade hatching blastocysts from a 20 year old donor but BFN.  It just goes to show you can't put a reconditioned engine in an old banger!!

When I was on the BCP prior to OEIVF I had AF type pains nearly every day which drove me mad.  I switched to a different BCP prior to DFET and the pains were not as frequent or as bad.  However, when I was having the DFET I starting getting AF type pains a couple of days before I even had the transfer, so from about day 15 of my cycle. 

I get allergic reactions all the time from my cats and have had a rash above and below my lips since before Christmas which I think is some kind of reaction to something. 

I just feel like I'm not meant to ever have a baby now as my body just won't allow it.

What does everyone/anyone think?  Apart from thinking I'm mad!  I know that already!!

Thanks

Irishgirlie
 

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Irishgirlie first of all I don't think at all you're mad!! it's normal to pose some questions when we do all those treatments and have very good donors and embies and finally that doesn't work. It can be an horrible bad hasard but you're right, maybe there is something hidden that you did'nt find yet...
About immune issues : unfortunatelly if you don't do exams you cannot be sure that there is a problem or not because often those kind of problems do not have symptomes... The best way so is to do the basic exames for auto immune issues as like : anti bodies anti neclear (ANA); anti cardiolipin and anti phospholipid also the thyroid anti bodies and for rheumatoid factors and the basic of thrombophilia because many of those auto immune problems can cause coagulation of blood. Or often we demand these exams to someone who have had many M/C ; furthermore the pains you describe when you are on A/F sounds to me more related to another problem : maybe an ovarian kyste (they can appear because of hormonal treatments as far as I know) ; or a myome or polype? or an endometriosis? Normally the endometriosis do not affect the issue of a IVF if it is not done with our own eggs but with those of a donor ; but if we have ovarian kystes due to an hormonal treatment and not to an endometriosis in that case we should stay in pill for 2-3 months, in order to put ovaries on "repos" and then to check if they disappear; I know that because that happend to me once after the depot shot for down regulation the drug insted of puting my ovaries on repos it stimulated them!!  ^bigbad^ ^bigbad^ it's rare but that can happen unfortunatelly... I have had 3 kystes because of that and my physician told me if we don't wait to disappear and I do the attempt it won't work! so he put me on pill for 2-3 months and when the kystes desappeared I was ready again to restart the IVF.
About myome, polype the right way to check is to do a diagnostic hysteroscopy; but I imagine you have already done one or even more ?
Also it won't be useless maybe to do a pelvic exam and check chlamydia and mycoplasma but I suppose you do this before every attempt? (my physician advice me to do always one before every IVF)
Sorry if I put things that you know already, I just wrote down all the things which sound to me in a probable correlation but I'm faraway to be a ....doc!!!
Once again I'm really very sorry for the result of your last attempt and hope that the next one will be the good for you!! and thet if there is a problem you'll find quickly the solution!!  ^hugme^

PS have you check for hydrosalpinx? It can causes pains in the lower abdomen or pelvic area....It's rare but I thought it also...
 

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Discussion Starter · #3 ·
Thanks LittleCherry, I haven't had any of those tests.  I'm going to go and see my GP and see if I can get at least some tests done.
 

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Discussion Starter · #4 ·
Just realised this post has been moved to here from where I'd originally posted it.  Now I can see there is LOADS of information on here about immune issues etc.  That should keep me busy for a long time!
 

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Irishgirlie: have you had a hysteroscopy/laproscopy to check for endometriosis?  the discomfort on BCP makes me think that it was something probably estrogen mediated, but then I would have thought the discomfort would have exacerbated when you started stimms/estrogen meds for DE... but at littlecherry says, it could suggest a cyst, but they tend to have to be fairly large to cause pain and would show up on ultrasound and presumably you had several of those during your OE and DE.

Unfortunately, the odds of success with IUI at +35 isn't great, so it probably doesn't make much sense to read too much into that not being successful.  Even a DE is not a guarantee of success first time round.  However, your history of allergy does raise your odds of being someone with autoimmune issues, and if you did have endometriosis, that would up your odds to almost a certainty. 

I would definitely try and get the level 1 tests (see level 1 in the faq) done by your GP and think about whether you want to go down the full immune testing route - or perhaps even just try empirical treatment (under T in the FAQ) - reprofit do offer steroids, intralipids etc (although, if you have intralipids make sure they dilute them - I have heard of ladies being given them at 20% dilution by reprofit which is probably not a great idea).

all the best. 
 

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Irishgirlie I would like to add that if you haven't done a diagnostic hysteroscopy I think it's an indespensable exam (especially after many negatifs); and it's important to do it with a good specialist; I would start from that and then with the immune test if there is nothing found in the hystero...
Good luck!!  ^hugme^
 

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Discussion Starter · #7 ·
Thanks to both of you for your answers.  It gives me a lot to think about.  I've had to pay for all my treatment and am at the end of my funds now.  I will try and get some tests done on the NHS but if my GP won't go for that I may have to give up on the whole thing. 
 
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