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Good afternoon Agate

Could I please ask for your help in understanding my Chicago blood results taken two weeks ago. I am under the care of ARGC.

TH1 : TH2                                        42.5                      ( 13.2 - 30.6 )

IFNg : IL10                                      22.2                      ( 5.8 - 20.5 )

Histone antibodies                            Negative

Cardiolipin Ab IgG                            3.9                        ( 0 - 17 )

Cardiolipin Ab IgM                            3.7                        ( 0 - 15 )

NK ASSAY ( 0 % killed ) Panel

50:1                                                20.1                      ( 10-40 )
25:1                                                16.1                      ( 5 - 30 )
12.5:1                                            11.4                      ( 3 - 20 )

IgG conc 12.5 50:1 *                      12.4                        %

IgG conc 12.5 25:1 *                      11.1                        %

IgG conc 6.25 50:1 *                      11.5                        %

IgG        6.25 25:1 *                      11.8                        %

CD3%                                              75.7                      ( 60-85 )  %
CD19%                                            9.4                        ( 2-12 )    %
CD56%                                            13.6                      ( 2-12 )    %
CD19 plus, CD5 plus Cells                  5.7                        ( 5-10 )    %

Everything was normal and all thyroid function normal with TSH 0.81, Free T4 15.2 and Free T3 4.9


Thank you.

Leigh x
 

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Discussion Starter · #22 ·
TH1 : TH2                                        42.5                      ( 13.2 - 30.6 ) - quite high - see cytokines in faq - argc like humira for this

IFNg : IL10                                      22.2                      ( 5.8 - 20.5 )

Histone antibodies                            Negative

Cardiolipin Ab IgG                            3.9                        ( 0 - 17 )

Cardiolipin Ab IgM                            3.7                        ( 0 - 15 )

NK ASSAY ( 0 % killed ) Panel

50:1                                                20.1                      ( 10-40 ) - quite high - argc like steroids and ivig
25:1                                                16.1                      ( 5 - 30 )
12.5:1                                            11.4                      ( 3 - 20 )

IgG conc 12.5 50:1 *                      12.4                        %

IgG conc 12.5 25:1 *                      11.1                        %

IgG conc 6.25 50:1 *                      11.5                        %

IgG        6.25 25:1 *                      11.8                        %

CD3%                                              75.7                      ( 60-85 )  %
CD19%                                            9.4                        ( 2-12 )    %
CD56%                                            13.6                      ( 2-12 )    % slightly high NK concentration - again, argc like steroids and ivig - can you ask your gp to check you for vit D deficiency in case that is causing the problem here?
CD19 plus, CD5 plus Cells                  5.7                        ( 5-10 )    %

Everything was normal and all thyroid function normal with TSH 0.81, Free T4 15.2 and Free T3 4.9
 

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Hi Agate

Thank you for your prompt reply. I have had my Vit D checked by my GP and my levels are 76.1, I understand that the range is greater than 75. Do you think it is still too low as only just past the lowest value? I am taking Vit D supplements!

Thank you again

Leigh x
 

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Discussion Starter · #24 ·
please can you take a look at the supplements bit of faq- different labs measure in different units and it also depends if you have other issues like endometriosis.
 

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Hi agate quick question -
Been on humira for 2 rounds & cytokines now in a normal range.
I am now cycling and just had NK cells retested (which were high)
My CD 56 originally was 16.2 and my CD 19 plus 5 cells was 2.6 (low) it is these results that I am interested in as don't know what happens when they are too low - would i be more predisposed to have to have IVIg? Or intrapalids?
Many thanks in advance
Asp x
 

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Thank you Agate - I will check the FAQ's x

Asp

I have done a little bit of research for you and as far as I can see the levels lower than the range are nothing to worry about. They certainly don't try and bring them up. So when are you hoping to cycle? xx
 

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Thanks Leigh I was just wondering if they are low and high whether they would balance out with IVIG.
I am cycling now I am on Day 4. Are you taking Humira?

Asp x
 

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Asp

I will be taking Humira all being well with my TB blood test. I had it on Thursday so I'm still waiting on the result. Can you remember, off hand, how long it took? How did you find the Humira? Did you just have the one course and the retest three weeks later? Did you try anything radical diet wise? Sorry for the million Q's!

4 days in, when do they scan you first time for follicle growth?

Leigh xx
 

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Hi Leigh they scanned me yesterday I am on the short protocol. That was my baseline scan. The TB took a few days from what I remember. I found the humira ok no side effects. I was hoping for a spondilosis cure! Everyone is the same first injection then second two weeks later and then retest three weeks later I had to have 2 courses. All been a vit of. Whirl since the.
Take care Asp x
 

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Discussion Starter · #30 ·
aspirational said:
Hi agate quick question -
Been on humira for 2 rounds & cytokines now in a normal range.
I am now cycling and just had NK cells retested (which were high)
My CD 56 originally was 16.2 and my CD 19 plus 5 cells was 2.6 (low) it is these results that I am interested in as don't know what happens when they are too low - would i be more predisposed to have to have IVIg? Or intrapalids?
Many thanks in advance
Asp x
you'd want your cd56 to be in the normal range and wouldn't be too fussed if your cd19 5 is a bit low. probably intralipid if the only remaining problem is cd56 or maybe steroids but not if your th1 is now quite low.
 

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Hi Asp

Can I be a nuisance again? Haha!

I have been told by Mr T that I will be doing the short protocol when I eventually cycle either in April or May depending on my cykotines! When you say yesterday was your baseline scan, is that the first time they scanned you this cycle? When you did you day 1 bloods did they give you the result that day & then tell you that you were cycling? What drugs are they using on the short protocol?

Leigh xx
 

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Hi Leigh
The baseline scan was for follicle growth it's about the third scan I had - but everyone is different. Yes they gave me the results that day but I didn't start cycling till about the third day because the hysteroscopy had made the results inconclusive due to a continuous bleed. I actually started on day 3 of blood tests but most start injections on the second I think. The drugs are fostimon and merinal and the combination can vary - I have been put on 600 units for now I am also taking clomid & viagra. Again everyone is different but I imagine you will use fostimon & merinal during your cycle.
I hope this helps?
Asp x
 

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Asp

Oh and why are you taking Viagra and clomid? How much was the Viagra? haha! You said it made you faint! Did you have lining issues previously ~ is that why they are giving you it? Do you live in London? Have you got your NK results yet?

Leigh xx
 

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Discussion Starter · #34 ·
viagra for uterine and ovarian bloodflow - info in faq under Lining issues.
 

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Hi all I hope that you don't mind me joining in? I had my NK cells essay and ratio results back yesterday. Apparently I have a slightly raised NK cell count (should be 12 and mine is 14) and my helper cells are raised. So I'm having pred 10mg then raised to 20mg and ivig one before I take northistrone and one between day 4-9 of stimms.

I just wanted to know if the ivig hurts? It sounds horrible. I will have it done but was just curious!

Thanks ladies
X x x
 

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Discussion Starter · #36 ·
have a look in faq under ivig.
 

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Sorry agate, I did look there first but could't see anything about the actual procedure. I'll take another look.

X
 

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Discussion Starter · #38 ·
the only painful bit is having the needle put in your hand/arm for the cannula.... after that the side effects etc are in faq.
 

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Cheers ears x
 

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Hi Agate,

Just read your thread on immune issues and the FAQ ( you are great help by the way)

I have PCOS and have been on metformin for the last 4 years now.. Had my first cycle of IVF which failed, tested today (OTD) with a BFN  :-\ :'(

I had 5d transfer and the blasts were of good quality but I had flu like symptoms, cold and cough, sore throat the day after ET.. I did wonder where it came from as I didn't have any symptoms before.. I initially nought it could have the ice cold water I had before my ET but now reading through your thread it might have been my NK reacting to the embryos..

I need to get an appointment with my clinic (Oxford) to book in for my next cycle but do you think I need to get them to test my NK cells or have all of the immune tests done just in case..
Do I need to see a separate immunologist as well?? I am so desperate to move along after my failed IVF but would like to check everything before attempting the FET ( have 4 frozen ones from the IVF cycle).. Please advise..
 
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