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Discussion Starter · #41 ·
i don't know your clinic's view of immune issues or whether they would be helpful/unhelpful about you exploring this.  They are likely to point out that if you only had the symptoms once, it could be a coincidence.

I GUESS you have to see what support your clinic will give you for immune tx/tests and if you aren't happy to seek a second opinion elsewhere?

if you have a history of ectopic though, my first thought would be to explore the greek infection tests. I'd GUESS at the possibility of chlamydia causing tubal damage and raised NKa
 

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Yes I had ectopic once before.. What are these Greek infections test - is it the serum clinic you mention in our posts? Do I need to get there or the tests or send samples to them from here??
 

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Discussion Starter · #43 ·
the infection tests can be done by post.  there is info in my serum file and in my faq.
 

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Thanks agate. I will I've it a go of my clinic refuse to test them when I go down for consultation... But I don't think they will do it after just one attempt with ivf.. :(
 

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Hi Agate, i had my follow up appointment today but the consultant was very specific that I don't need to get my immune tests done as I had been pregnant before but I would like to check if anything was wrong before doing my next cycle. However my clinic don't support them in principle so even if I get my tests done externally I don't actually get the treatment if I go with my FET cycle with them... Not sure what i should do now?? Do I take my chance with another FET before I do any tests... Is there a possibility that I don't need immune tests because I had been pregnant before? Confused...
 

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Discussion Starter · #46 ·
Unfortunately there is no way to know if immune tests or tx would help you.being able to get pg doesn't tell you anything other way. Its totally possible you will get pg with your fet without doing anything else. That's always the big dilemma about immune as you will can almost never be sure you need it.
 

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Hi agate, would like your opinion on the below..

I tried speaking to serum clinic (they were very helpful btw) but I was told that immune testing is not something they do in-house and don't recommend to have it done after just one attempt of IVF instead I will need to get tested for infections - chlamydia as you mentioned earlier..

I think I will get started on it, but wonder if I should also get the NK testing done elsewhere because of the flu like symptoms soon after my ET or is there any indication of raised NK cells with the infection tests ???
 

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Discussion Starter · #48 ·
if you had chlamydia that might CAUSE raised NKa so might CAUSE the flu-like implantation reaction.

serum can arrange for you to do the NK testing with Dr E if you want it, or you could maybe send bloods to RIC.

also think about just asking for steroids and clexane from your clinic without testing (see Treating Empirically in faq)



 

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Thanks Agate. I have a chat with Peny today which I should say was very helpful.

Think I might get myself tested for infections with my next period and depending on the results try the empirical treatment if my clinic accepts it or try the NK testing...it is just a long wait now for my next cycle for testing now!!!
 

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Hi Ladies,
                Wondering if anyone can provide me with any insight into what my problem might be?

Back in late 2011 I had my first DE IVF at Reprofit x 2 grade A blastocysts and got pregnant with twins but miscarried 8-9 weeks later. 2nd IVF at LWC negative. 3rd IVF at Dogus negative (3 grade A blastocysts).

Chlamydia test at Serum negative.  Chicago Tests showed high NK cells and TNFa and other blood tests showed Active Protein C Resistance blood clotting issue. DH's karytype came back normal. Treatment for immune issues consisted of intraipids, clexane, predisolone, aspirin etc.
Most recent DE IVF after this treatment April 2013, ended with a negative result - 3 grade A blastocycts? I am at a loss as to what to try next. :(   
 

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Discussion Starter · #51 ·
have you done a consult with serum?  has someone done hysteroscopy to check the uterus after fibroid op?

considered low dose pretreatment with resveratrol, vit d and fish oil, then maybe gcsf?

checked sperm dna fragmentation?
 

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Hi Agate,
            Thanks Agate-No, I haven't had hysteroscopy since keyhole fibroid op December 2012. However, before the operation my uterus lining was able to get to around 9mm-10mm during each IVF  cycle. However, during my last cycle I was on 8 progynova a day from day of donor's EC(2 vaginally)only got to 7.9mm(figure it must be something to do with having less estrogen receptors in my lining?). I Will consult Penny at Serum regarding hysterscopy 

I have had vitamin D level checked and it is in the 80s-but will look into resveratrol, fish oil and gcse.

Will also look into DNA Fragmentation test-although my FS advised that shouldn't be necessary as doesn't appear to be a problem with fertilisation. She also advised that DH and I should consider sperm donor if this last cycle failed-DH isn't at all keen on that. :(



 

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Discussion Starter · #53 ·
when you get your period, do you have profuse, bright red blood... brown spotting?

lots of red blood is reassuring.

if you found out that the sperm dna frag was poor, then it might help either to convince your partner to try DS or to try supplements/antibiotics to improve the dna frag?
 

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Hi Agate,
              I'm perimenopausal so I still have to down -regulate with Gonapeptyl. When I do have a period it tends to start as light brown spotting and then consists of brown old looking clotty blood with some red blood-5-6 days duration (mostly comes out after a BM-sorry tmi) :-[
during my last cycle  scan on day 9 of having taken Progynova-showed lining of 6.5mm-so the FS upped my dose from 3 Progynova a day to 8-then it got to 7.9mm by day of ET-(day 15).

DH has been on Wellman Conception, Vitamin E and C for past 6 months. Always able to get Grade A blastocycts.
 

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Discussion Starter · #55 ·
was your post-ivf bleed all red or some brown - if some brown I'd think about checking the uterus again for scar tissue.

 

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Hi Agate,
            Post ivf period was mainly mucousy brown with some red.

Would there be possible scar tissue if keyhole surgery to remove 1 paratubal cycst and 2 subseroul fibroids( I thought these were on outside of uterine wall and not impacting on actual lining?)
 

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Discussion Starter · #57 ·
mainly brown does not sound like a great lining, whatever it looked like on scan.  that surgery shouldn't have caused intrauterine adhesions, but I'd still feel that the lining needs to be checked for scarring/adhesions.
 

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Hi Agate,
              Yes, you are right and I suppose I also have to take into account the fact that I had D&C after miscarriage.
I will look on your Serum FAQs page regarding hysterscopy. Thanks for all of your help. :)
 

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Hi all, I was just wondering if you could help me? This is my 3rd cycle and we have been through it emotionally as we had 22 mature eggs and only 4 fertilised, so could be a bit run down. We had two put back yesterday both grade 2 :)

I'm taking pred 20mg and had 2 ivig's this cycle but I have today started with a sore throat and a poorly tummy and lower back pain. Is this a immune reaction again?

Any suggestions would be great.
 

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Discussion Starter · #60 ·
upset stomach rarely suggests immune reaction to implantation, neither does lower back pain.  sore throat might but its hard to know if its just a bug you are fighting rather than a reaction to implantation if it only happens once.
 
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