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Discussion Starter · #1 ·
Sarah

Could you advise about the risks/benefits of PGD?

I have unexplained secondary infertility (we have a five year old son) and have been ttc a second child for 4 years.  I am 41 years old and started sniffing last week on my first cycle of IVF.  

Does PGD offer our best chance of success given my age?  Is there any information on relative outcomes in older patients (i.e. PGD vs non-PGD)?  What are the implications of PGD for the length of time between ec and et?  

We know that it's very expensive but would like to give it a try on our first attempt if this increases our chances significantly.

Many thanks

Kim
 

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Hi Kim

I will be interested to see the response.

Also considering the above due to high levels of embryos not suviving thawing process. Our last lot were all blastocysts and they all perished :(

Lots of luck

Lou xxx
 

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Hi,
PGD is a very specialised treatment option. I don't have stats to hand but the theory is that chromosomal abnormalities could be picked up prior to ET. As the level of chromosomal abnormalities does increase significantly after the age of 40, it would be a logical step and the thought is that in the future it will be a standard treatment rather than specialised. Regarding the delay between EC and ET, that isn't a problem and embryos tested will reproduce the cells removed at this early stage of development. The down side is that you have a higher chance of not even getting to embryo transfer because all embryos are found to be abnormal or do not develop for long enough. It's a tough decision to make and I would advise getting further info from your clinic on it's stats on outcome. I presume that your centre does do PGD as only a few do. Hope this helps.
Sarah
 

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Discussion Starter · #5 ·
Hi Sarah

thanks for the info. Yes my clinic (ARGC) offer PGD although the chromosomal analysis is done in Chicago. We went there specifically because we saw stories in the media about PGD and older women having IVF last year.

I think my feeling is that if we don't make it to ET because of abnormalities that's OK - it's just pre-empting an inevitably poor outcome and at least we'll know what the cause was. I did ask the embryologist about stats and she said their results were very good but didn't give me actual numbers. Maybe I'll press them on it.

Thanks again - I'll post on our decision and progress

Kim
 
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