[Cloudy]

Happy chatting Lister ladies xx

Welcome everyone - here's a lovely new place for you to chat. The old thread has been locked but you can find it here if you want to read it: http://www.fertilityfriends.co.uk/forum/index.php?topic=363874.0

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xxx

 

[Cloudy]

BFP and Beyond Chat

Please be advised that there is a separate thread for ladies who have had treatment with Lister to chat about their BFP (and beyond) which you can find here:

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Cloudy - Moderator xxx

 

[Zara03d]

Hello ladies,

Hope everyone is well.

2ForJoy - I am on 2WW however for PGS results for my frozen blastocysts.

Claudia H - thanks for confirming. Have you had to have any treatment at Lister for immunes?

😊🙏

 

[Claudia H]

Hi Zara, no, luckily my results showed I didn't need any. X


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[Zara03d]

Thanks Claudia.

When I get to do transfer (currently doing ivf cycles to bank with pgs testing), just wondering whether worth doing the blood tests for immunes as done everything else so when time comes no regrets regarding a FET working or not if makes sense. Might raise with James when ready to consider using blastocsyts.

Still waiting on PGS results for now and preparing for next IVF cycle in January 

 

[Claudia H]

We did just that earlier this year. 3 cycle banking for PGS. We also did immune testing speculatively as we just wanted to rule it out. James was happy with that.

X


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[Zara03d]

Thanks Claudia. I was thinking the same to rule it out as I already have a not so normal uterus due to Ashermans scarring and whilst 5 surgeries has reduced the scarring the uterus open cavity is lot smaller so just thought might as well rule out immunes too that way only the uterus cavity and lining to focus on. Will run it by James when ready for next stage if we decide to transfer alternatively we will move to surrogate.

We previously did a 3 cycle package at Create last year and now moved to Lister. Fingers crossed for better pgs results at Lister. Still waiting on mine and time going very slowly 

 

[Claudia H]

Everything crossed for you Zara! Sounds like you could really use a lucky brake!!! X


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[Zara03d]

Thank you. I would love a positive break 😊🙏

 

[2ForJoy]

you ladies get the break you deserve xx

Where is everyone at in their cycles right now?  Any news Zara?

AFM- The witch finally arrived on Sunday- i will admit I had a couple glasses wine Sat night to try and relax- it obviously worked!  Had a scan yesterday which confirmed the lining is thin enough to start   Did my 1st Stimms last night- 225 Gonal F- bit of an increase since last cycle due to my declined AMH.  Back on Monday with estimated EC 27th... mind you if I respond like before it could be earlier  How long did it take for the side effects to kick in?  I defo feel worse this time around already

 

[Zara03d]

Thank you 2ForJoy 😊 pray 2018 is year for us all 🙏

2 weeks today still waiting on pgs results and next ivf cycle to start in January 😊🙏

My stimulation side effects started when my dose was increased halfway through with the 1st one at Lister being the worst ivf cycle in terms of side effects. However 1st time I did long protocol and my dose ended up at 450iu menopur with twice daily nasal spray 🙈

Fingers crossed side effects not too bad for you x

 

[Zara03d]

So news received last night all 4 were abnormal from 1st cycle at Lister. Prior to that from 3 cycles at Create tested 7 at end and only 1 normal.

Protocol was changed to long this time, more eggs, more fertilisation, more blastocysts frozen with top grading yet all were abnormal.

I just don’t get it. Tried hard not to break down on phone with embrology guy but then just broke. Think he felt so bad he must have told James as next I got email from James within the hour of phone call.

I sat at work end of day when got call and cried on own. Then sat in car cried had panic attack and then just cried for ages as whilst messaged hubby result did not want to go home.

The lab is going to see if offsite genetics lab can see anything in all my pgs results from both clinics. I know when I emailed my Create pgs results to clinic in USA they could see no correlation and just unlucky.

Likely now to do all genetic bloodbtests kyrotype ones to see if something in me or my hubby. Lab said there is possibility that I have “balanced translocation” whatever that means and least if they rule that out for me and hubby then either that or just unlucky. Either way if do have in dna then cannot change that just means going to take lot more ivf cycles to get normal ones and always the risk that even normal one will miscarry if issue with my dna. Also said if clinic and we focus on that first before next ivf cycles least we know one way or other.

I thought my journey was hard when nhs ruined my life when they removed my miscarried baby in 2013 which was one and only one I conceived naturally and they basically scarred my uterus so much I can no longer conceive naturally as dr admitted using a knife to scrape my uterus. Despite 5 surgeries here and abroad have been told there is always change I will have to have gestational surrogate. Even tried to use surrogate in India in 2014 and 2 failed transfer but dr there said my lining was not as bad so changed dr in London who also recommended scarring specialist in LA went there twice and he said to focus on banking normal blastocysts at least 4 before deciding about transfer to my uterus or surrogate again.

So this time at Lister first time on 4 and half year journey get some good news, AMH doubles, long protocol worked with more eggs, better fertilisation, better quality blastocysts frozen and for once my crap uterus lining was actually looking slightly better. Then just get news last night and think when you think there is no much lower you can feel then you find it.

My heart broke on the phone that lab guy had to repeat the result as could not take in. Was so hoping for 1 normal.

I just don’t know what to do anymore x

 

[Efi78]

Zara
May I ask of there might be a male factor issue? I have also had several miscarriages and doctor suggested sperm dna fragmentation testing. We have done karyotype testing and all is good. Doctors suspect a balanced translocation only when the abnormal embryos have the same chromosome problem for example all have trisomy 18. Even then the chance to transfer to child is 1 in 4.

 

[Zara03d]

Have no idea hun they looking to run kyrotype blood tests on both of us so hopefully that will be ok.

Not sure as my pgs results scattered different numbers not sonclesr that same number for each abnormal if that makes sense although 1 of the 4 embrology did mention something about 18 was in 1 of them. Don’t know if has to be consistent across all of them.

Sompleased to hear your kyrotype bloodbtests aregood that gives me some hope today that not all doomed for me as I am expecting the worse. I have written myself off to be honest.

Did you do the sperm dna fragmentation at Lister? Also did you do kyrotype blood tests at Lister too?

Thank you for advice means a lot when just feel so lost x

 

[Efi78]

Hi Zara
They have to be consistent for the doctors to suspect translocation. We had karyotype testing after the TFMR for T21. It came back clean and doctors said we were just unlucky. 3 years down the road another two early miscarriages. The doctor suggested sperm dna fragmentation testing as we have male factor and wants to see if this is the problem.
If that helps I am also completely lost today. We are preparing to accept childless life.
To top it all up I had visitors who styaed with us for a week. They have two very cute children that were conceived naturally and relatively easily. Their mother couldn't stop complaining how difficult her life is, how difficult the children are, none helps her etc and i wanted to kick her out of my house and scream!

 

[Zara03d]

Hello Efi78,

Oh totally understand how you feel! People just don’t realise how lucky they are 🙈

When Lister did my EC they said my hubby’sample was ok did not need to do ICSI. Wonder if they will suggest the sperm fragmentation after doing kyrotype blood tests for me and hubby.

Have Lister said they cannot help anymore?

I know what you mean as more of these results come my way more the goal seems distant 😢

 

[Efi78]

If his sample was ok the i think it is unlikely they will ask him to do dna fragmentation tests. May I ask what is your age?

Lister didn't say they can't help anymore, they do their best. However I have started feeling fed up and having a baby has become more like a "tick" in the box rather than something I long for. What we have been through is unbelievable. We have been incredibly unlucky. We correct an issue and then as soon as we correct one problem some new issue comes up. I have started to believe that God doesn't want us to become parents.
And then you have an utter idiot complaining for her children and how difficult they make her life (honestly they are both angels. Cute, quiet, smiley. 18months and 3 year old. I struggle to see how a parent would ever find these two difficult). And you look at her and you really want to tell her to f.. off but you have to be kind and smile. Thank God she left today. I have to deal with my issues. We are so sad about the sperm news.

 

[Zara03d]

Did create cycles 35/36. Lister cycle just turned 37.

I totally understand that get through 1 things and then life slaps another problems in your face!! I am starting to feel like will the issues ever end.

Couples and ladies like one staying at your place just don't realise how lucky they are to be blessed. I have a colleague at work who announced she very earlier stages (less than 12 weeks) however already having a toddler means her news now is like her world ended. You would have thought she said that someone died rather than giving happy nes. She walking around so miserable. I trying to keep out of her way especially as all she knows is that I am struggling to conceive yet still all about her and how is she going to cope with 2 etc etc. I just think in my head when people talking no idea how blessed you are 😢

I am so sorry about the sperm news you have received. What have lister suggested? stay strong which is easier said than done and I should probably listen to my own advice 🙈😳

 

[Claudia H]

Zara,

Really sorry to hear about your PGS results. Absolutely not what you were hoping for. On top of everything else, you deserved a brake.

If you have the means though, I'd say don't give up. At 35-37 it's unlucky that your blasts were abnormal but it also could just be a factor of age. At 39 I had one normal out of 6 and that was considered a decent - or even lucky - result. It's unlikely that all your eggs are abnormal by your age but it's fair to say that sadly a lot will be so this disappointing result may just speak to that. But that's not to say that further cycles wouldn't give you normal embryos, in fact at 37 I'd say they probably will.

I know what it's like to feel you've had so much bad luck you can't take anymore - I really do. But you have to also remember that it's the people who don't give up who have the babies.

Karotyping sounds like a good idea in the meantime to rule that out. Also we were never recommended ICSI but after 5 failed cycles we pushed for it and turned out DH did have mild DNA frag so ICSI has helped.

Xx


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[Zara03d]

Thanks Claudia H.

I know just need to pick myself up again and try to keep moving forward just feels a bit crap at moment.

I am also convinced they will find something on kyrotype for me or husband or this balanced translocation thing for me 🙈

We did ICSI at Create for all 3 cycles as they do ICSI when doing pgs even though hubby’s sperm was ok. However Lister said they would decide about ICSI on day of EC and would only do if looked like we needed it and they said we did not. Did you do the sperm fragmentation yest? What does it involve? 🙈