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Queenie - first of all,  massive congratulations - 28 weeks now, wow!Totally up for a meet up when we can..

Klik, am extremely sorry for the latest outcome, have already let you know personally anyway, but sending you continued lucky wishes and perhaps there's going to be another natural miracle when least expected..

Briss thinking of you and hoping that it's finally going to be your time again very soon!

Pritamin, I was with reprofit in Brno and can highly recommend Dr Pavel who is the head consultant there. For both OE and DE. We didn't need DE in the end but Dr Pavel would have fully supported either option - he never gave up on me.

Mouse good luck with the upcoming cycle!

I'm.so in awe of everyone cycling during Covid times - it needs so much additional focus and patience!

Our daughter is 9 months old now and basically a covid baby in the sense that she was born during lockdown and has hardly had any contact with anyone but... I am so grateful every single day!!
 

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Hi ladies

Really pleased to hear of the good news on this thread

Anyone done stem cells to help the ovary?

Should we organise a virtual coffee morning with private details for those who attend?

Thanks
 

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Hi

Congrats to all the bumps and little ones

Lovely to hear from the lady’s who were here before...such incredible journeys and all during Covid it’s even harder!!

I am day 9 at create last cycle of 3
With tamaxifin
Two follicles hardly moving at 5mm
E2 is below 50
And Lh was 2 now 11

Should they start stims every other day...everything seem quite...


 

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With E2 so low the Tamoxifen isn't doing much.

My personal experience is that on a naturally long cycle like that the quality isn't great - so I would be tempted to leave it this month and come back next month, but then after so many failures I learnt to cut early when it didn't 'feel' right.  Not everyone follows that philosopy.

If you want to try just to see what happens you could add in a little pergovaris, or something similar.
 

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Hello thanks Queenie
I feel the same way
Consultant felt we should carry on
Some months are good some not

I thought maybe bemfola 75 might help
Seems like the cycle is still day 1 not 12
 

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I found the trick with a nearly natural approach was to let you body 'tell' you when it was a good month.

You can't spend money every month, and collect every egg.  When you are aiming for just 1 good quality egg don't force the ones that aren't playing ball, spend the money on the next month.

Every time I thought, oh well let's just go for it anyway and collect and see it just 'might' do - I was dissapointed.
 

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Hi ladies,

Hope you are all well. Queenie hope you are feeling ok as you get towards the last part of pregnancy.

Dorchester how’s the cycle going?

I’m currently in a 2ww for our only frozen embryo after the cycle getting cancelled last year and having the hysteroscopy. We ended up transferring on a thin lining but on consultation with the consultant and him speaking with the team.

I am just after a bit of advise. So I’m doing a medicated frozen cycle so down reg and estrogen and progesterone. Will AF likely break through anyway or is it likely that because I didn’t ovulate that af will hold off until I stop the meds? The reason I’m asking is I had to cancel my 2nd Pfizer vaccine as it was today and I’m in 2ww. If I can try and get it next week and hold off starting my next fresh cycle a bit then that would be great.

Any advise would be fab.

Thanks all. X
 

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Hi ladies,

I'm new here and I've been following this thread over the last few weeks - it's been very reassuring to read advice from women on similar journeys, thank you.

I'm 39 and have low AFC of 3 in total and my husband (42) has low sperm count and low on motility and morphology. Last month I had my final cycle of a 3 cycle natural modified package at Create St Pauls. 1st cycle = 2 eggs collected, 1 mature, failed fertilisation (PICSI). 2nd cycle= 1 egg collected, not suitable for ICSI. 3rd cycle = 2 eggs collected, 1 mature, failed fertilisation (PICSI).

The clinic have said it's probably an egg quality issue but they can't be 100% and suggested our only options now are Natural IVF (>5% chance) or DE. Since the final round my husband saw the urologist at Create and was found to have a swollen prostate, so has been on antibiotics for that. We have both started taking ubiquinol and various other supplements and he'd been taking Proxceed prior to our cycles. I have now started taking Proceive Max instead of Wellwoman too. We'd like to try at least one more round so are waiting until April to see if the antibiotics have had any effect on sperm and ubiquinol on egg quality.

We want to get a second opinion, although I'm pretty certain other clinics will say the same, and are interested in whether procedures like IMSI or calcium ionophore can help with the failed fertilisation - Create don't offer these, but I see that CRGH do. I was wondering if any ladies have any experience of these procedures or could suggest any clinics that we haven't looked at? Just not really sure where to turn at the moment and natural IVF seems like it might be more stressful due to the high cancellation rates because of ovulation before EC.

We have had IVF success in the past (with abcIVF -part of CREATE) and had our DD in 2018, who we are eternally grateful for. That was a mild stimulation cycle, 5 eggs collected, 2 blasts, 1 day 5 transfer resulting in DD. We had a FET last year with the remaining blast ending in MC.

Thanks so much.x


 

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Mouse - Congratulations on being in the 2ww.  The only thing to say is do belive it will work - act as if it already has worked, don't stop medication until you have had a blood test to check.  In order to know if your dose of medication is enough to delay AF can you share what does of which meds you are on?  Was this medicated only cycle or did you ovulate as well?  Have you had a progesterone taken to check as well?

kydd081 - Hi and welcome,  I'm so sorry for your recent cycles.  But you are still getting eggs!.  A lot of the descision about where to go and who to go with is personal preference, but I would agree if you are not making more than 1 embryo per cycle then a natural approach is best.
If your fsh/lh is not too high then really minimal drugs might work for you.
 
I also agree it is likely to be a mixture of both female and male factors, although now you have fewer eggs and probably poorer quality than a couple of years ago the male may be more important to optimise than before.  Are you able to share you d3 fsh, amh, cycle length (for a normal cycle),  as well as his motilility/morphology?

To a certain extent all things are possible, but OE is hard work and intense on both emotional and financial resources. 

Dorchester - did you leave it this month?  I hope your consultant didn't push you into carrying on if it didn't feel right for you.  It is very hard to walk away early on, but your response to treatment, getting a nice high E2 and low LH really are the best predictors for your egg quality (before egg collection).    It's not their money they are spending, and they don't need to worry about a poor outcome, they just blame it on your eggs, so there isn't much incentive for them to optimise it, just focus on getting an egg, not worry if it's a good one.
 

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Thanks queenie. I’m 7dp5dt today and have a positive test! Feels very early days but hoping it sticks! I still can’t really believe it! I’m on 2xestrogen patches, 5x tablets and 2x pesseries. Plus 2x cylogest pessaries. Oh and 75mg aspirin. They did progesterone check on the day of transfer and must have been ok as didn’t get a call back. Think I have to take meds till 12 weeks if I get that far.

I’m not sure whether I will bother with bloods as they will just check hsg? It’s a trip up to london and another day off work and not sure if it will add anything.  Will book in for a scan with the clinic. My odt is Saturday so hoping there is still a line on the tests by then!
 

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Hi kydd081

Just jumping on here to say I would highly recommend CRGH and our consultant (Paul Serhal).  I had a low afc (6) and underwent 3 low stimulation batching cycles with PGS testing last year.  Our consultant recommended calcium ionophore among a number of other things we hadn’t tried before (human growth hormone, DHEA). Each cycle half the embryos collected were injected using PIMSI and the other half were ICSI.  We got 4 PGS normal blastocysts (2 ICSI and 2 PIMSI) from the 3 cycles; they thought we’d be lucky to get 1-2 normal blasts based on our history.  We are thrilled with this result and are hoping to do an FET next month.  My husband previously saw Mr. Jonathan Ramsey (Urologist) who I would also recommend along with Melanie Brown (Fertility Nutritionist).  Mel put us both on a number of supplements which I think really helped as well.

Best of luck to you and to everyone else reading this X
 

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Mouse - YEAH - big congratulations!  fantastic news.

I would check both Progesterone and HCG,  and check HCG is doubling (it can be topped up if needed).  But a proper positive test at d12 post ov is fantastic news. 

I used a variety of private blood clinics, you can do it without going into london if that was a worry - medichecks do it through the post (but it takes a couple of days).  It's worth doing because your progesterone can be topped up if needed (mine needed to be a bit).
 

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Thanks at queenie123, yes the emotional and financial strain is a lot! I'm not sure how many more rounds we can realistically afford to do. Although if I don't give it at least one more try with OE, I think I'll always wonder what if?

I feel embarrassed that the only marker I have for my own fertility is AFC, which is 3. I've only been with Create and they don't measure FSH or AMH - well if they do they've never discussed it with me. Back in 2017 when I had my initial NHS investigations it was something like 5.5 and my AFC was 16. So I can only imagine now with an AFC of 3, AMH is probably non existent. My cycles are 24-27 days.

My husband semen analysis from our last cycle was: density 5.00 million/ml, progressive motility 23.0% and normal morphology 1.00%. He actually gave two samples on the day and the second was better than the first.

We're really hoping the antibiotics he's been on and the supplements we're taking will help improve things. Although we both had covid at the beginning of this month and apparently that can effect male fertility so will have to wait until his next analysis in April to see.

Seafoam - thank you for all your advice. That's amazing that you managed to get 4 blastocycts! It gives me hope. I'm keeping everything crossed for your FET next month.

I'm going to contact CRGH to arrange a consultation and will see if we can see Paul Serhal - just waiting for all my notes from Create to come through. I've wanted to take DHEA as I'm sure my levels are low - I have an underactive thyroid which correlates with low DHEA - Create told me not to take it, so will be good to see what CRGH say.

I've seen Melanie Brown's name pop up before, I've just sent her a message to arrange an appointment, anything we can do to improve our chances is definitely worth it!

Thanks again.x
 

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kydd081 - 

I've posted before about different clinic approaches,  my AFC is often 1 or 2 (sometimes 3 or 4) on day 3.  I have not been capable of responding well for quite a few years.  I genuinly think with a very low AMH and AFC the most cost effective approach is as close to natural as you can get.  If you have an AFC of 5/6/7/8 then a mild approach will give you the best shot. 

We chose not to go with CRGH even though we had consults with them and were impressed becuase we would only be able to afford 1 cycle where we could afford 3 elsewhere.  We used Serum in Athens mainly. 

Covid can affect male fertility in the same way any nasty virus can,  it should be tempory 3months of so and the effects should be gone, although you can use the time to put him on a sperm imporvement protocol,  Proxceed, plus a long course of antibiotics, plus Vit C 1000mg and Vit E 400mg plus some ubiquinol are a start for him. 

DHEA didn't work for me,  it appears to work well for some women and not for others, and it actually made things worse for me (rather than better).  I have a couple of theories about why to do with Oetrogen metabolism and breakdown (Oestrogen Dominance), but there isn't much evidence to know who it might benefit and who it might hinder a bit better.  It took a very long time to clear it from my system as well (over 6 months) and I needed a lot of detoxing.  It would be interesting to know what they feel but definately ask them about the down sides as well as the positivies and if there is a way or test to be able to tell which group you are more likley to fit into. 

 

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Sadly my joy at my positive test was short lived. It’s definitely a chemical. The line has gone on a frer test after being quite strong. Feeling sad but hopeful this means that perhaps the aspirin and hysteroscopy has helped with any implantation issues and maybe we will get lucky on our next cycle.
 

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Sending you big hugs Mouse xxxx :( Chemical is awful but like you said it's also a shimmer of hope so try hold onto that.
Did you test every day and saw the line getting fainter?

Do you have any frosties left?

hugs, hugs, hugs xxx
 

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Hello

I am new to this thread and wanted to see if anyone could advise me if I should be considering mild ivf? My amh is 8.4 and AFC right ovary 7 and left ovary 4-5 but i do have an endo cyst which im scared could be burst at collection, so i am going to ignore that side for now and base things on 7 AFC.

My last cycle way back in.2016 was long protocol my amh was 26.8 and gave me 2.children. i want to try for the 3rd but now i am 39 and with am endo cyst.

My clinic has recommended short protocol this.time and see how we.go but given my age should I go straight to mild ivf. I have only.1 cycle to compare to and it will.be hard now.to match that I think.

 

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Hi Leanaj

I think that’s not too bad for AF count and AMH. Mine is half that and a mild short protocol works well for me.

Pritamin thanks, felt very cruel. Yes had blazing positives then fading line and confirmed with bloods. Back to the lister today for baseline scan to start the next fresh as no frosties left. Back to the worrying about if any follicles will grow and if we will get any embryos!
 

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Oh Mouse, I wish i could hug you now :( xxx
Let me know how your baseline went today.

I had a baseline on Friday with 2-3 follicles in the left ovary and 1 maybe 2 in the right and started with 300 menopur. I had a follow up scan yesterday and sadly there are only two growing in the left ovary. Nothing in the right. I'm beating myself up for thinking that I could actually end up with 4-5 to collect, should have known better. I know we only need one but I just can't make myself believe that the golden egg is among these two :(
Then I dread to think about the next steps if there will be any if this cycle is unsuccessful. My husband is not keen pursuing OE and throwing money out of the window and we did briefly discuss DE but not sure he will be that keen if it really came down to it....

Re mild protocol - i asked my consultant about it and she said when there's only 1-3 follicles mild protocol doesn't really make that much difference. Go figure! they all say different things which drives me mad.

Leenaj - that AF count and AMH sound good to me. What dose did your clinic suggest and what dose were you thinking? I only had one mild IVF with ARGC back in 2016 which ended in BFN so I don't really know enough about it, all i know that it didn't work for us and we spent about £15k with them on it :(

xxx
 

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Hi all

Thanks for shedding some light. They are thinking around 300 gonal f.  Mybclinic were just so negative or perhaps thats my perception that they aren't doing cart wheels but they have to be realistic.
 
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