Fertility Friends Support Forum banner
1 - 2 of 2 Posts

·
Registered
Joined
·
1,575 Posts
Discussion Starter · #1 ·
Hi to everyone facing MF problems,

Over the past years many of us have become familiar with the standard tests for MF. We ourselves have now had multiple failed IVF attempts and I'm doing a little post-mortem now.

Does anyone have experience of any new or advanced tests on sperm that looks otherwise "normal" - I'm thinking of fragmentaion DNA tests or anything similar.

http://www.scsadiagnostics.com/

Here's a snip from another source as well.

<snip>

Abstract

The SCSA® test assesses DNA fragmentation using established methods that are supported by 25 years of research published in peer reviewed journals. These and ongoing studies indicate that sperm with elevated DNA fragmentation, as measured by the SCSA® test, have a lower probability of supporting a successful pregnancy.

The severity of male factors should be assessed prior to determining the appropriate treatment of couples presenting with infertility. The most common screening for male factors in the infertility evaluation is conventional semen analysis, which measures basic parameters including sperm concentration, motility and morphology. Severe and irreversible male factors are often treated successfully with intracytoplasmic sperm injection (ICSI) by injecting individual sperm into the egg cytoplasm.

ICSI bypasses all requirements of normal sperm motility and sperm/oocyte oolemma interaction. The only requirement for fertilization and early embryonic development is oocyte activation and adequate DNA integrity. Thus, a test of DNA integrity is very helpful in deciding which couple would most likely benefit from ICSI and which might be advised to consider other options such as donor insemination due to decreased odds for pregnancy with the male partner's sperm. Table I lists conditions when DNA fragmentation testing could potentially benefit a couple.

SCSA® test parameters are weakly correlated with conventional examinations of sperm concentration, motility, and morphology (Evenson et al 1991, 1999). Semen samples with normal conventional parameters may have very poor DNA quality that contributes to infertility. Therefore, the SCSA® test offers additional clinical information not provided by conventional semen analysis alone.
<snip>

With warmest regards,
 

·
Registered
Joined
·
167 Posts
dear Flopsy.
Definitely food for thought for us if any sperm is ever found.
Thanks for sharing your research at such a difficult time for you,
Good Luck
x
 
1 - 2 of 2 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.
Top