Hi Estel,

I saw you posted this Q twice so wanted to reply.

I’m a big fan of PGS as it has saved a lot of heartache,time and money as we avoided transferring embryos that were doomed to fail/miscarry.
However, it’s important that the clinic is reputable and in my opinion:

uses NGS technology (as that detects mosaicism most accurately);
Biopsies on Day 5/6, rather than day 3;
Performs FET of PGS embryos;
Reports mosaic embryos (with detection level of 20-30% to 70-80%);
Will consider transfer of mosaics if no normals available.

Finally for us, we made normal embryos on cycle 6. I’m 39 and seem to have a high rate of abnormal eggs, even for my age.. If you are ‘old’ then it’s a most useful technology to help sift out the bad eggs.

It’s very unlikely to lose embryos due to the procedure if the clinic is experienced. On Day 5/6 biopsies, around five cells are taken from around 100 cells of the trophectoderm (outer layer that becomes placenta) so the development of the embryo should not be affected. I’ve done PGS on as little as two blastocysts in one cycle but they were part of a banking deal where I get up to nine embryos biopsied in a 12 month period. It’s less costly that way.

There is a chance that PGS will detect that all your embryos will be abnormal and so you wouldn’t have anything to transfer. That is heartbreaking. Though for me, it’s better than going through a transfer and getting a BFN a week or two later, or worse again, going through a miscarriage.. Some ladies want a transfer no matter what.

Best of luck xx

 

Thank you for replying and for all the detailed info. Yeap, that's what was also discussed by the clinic . They only do blasto PGS and already informed us on FET. And, they are not in favor of transferring unhealthy embryos, although if we sign they cannot do otherwise. We are new in this whole biopsy thing and are still trying to take everything in  and only hope for the best.
I most certainly prefer to have a successful ET rather than facing a negative result. We'll know in a few days I guess;

 

I second what mylittlepincushion has said. I produce a lot of great quality embies but sadly very few were "normal" and as I had lots of miscarriages so for me it was a no brainer as I knew what I was transferring stood a good chance. There is always the chance that none will be right to transfer but I have always felt I would rather know that than risk miscarriage or having to make a decision further in to a PG should the 12 weeks scan throw up unexpected news

 

Hi Estel, just wanted to second what pincushion has said as above.

PGS was an incredible diagnostic tool for us, after multiple double embryos transfers (all 5AA) all fail, we tested 10 of my embryos and 9/10 didn't pass. Very sadly the 10th one then didn't survive the defrost either... However, had we not done this, we would've transferred ALL of those embryos and they all would've failed.

I have since moved onto DE and despite not achieving a child as yet at least we know than any transfers we do are viable to start with. Had I been earlier on in my journey, I may not have done this, but Am now 8 cycles down and just cannot waste any time putting in abnormal embryos.

Best of luck to you xx